Gestagen versus oral contraceptive pills to induce withdrawal bleeding before induction of ovulation by clomiphene citrate in polycystic ovary syndrome
To compare between gestagen versus oral contraceptive pills to induce withdrawal bleeding before induction of ovulation by clomiphene citrate in polycystic ovary syndrome. Randomized controlled trial. Integrated Fertility Center and Agial Fertility Center. Fifty PCO female patients. The patients wer...
Saved in:
| Published in: | Middle East Fertility Society journal Vol. 19; no. 2; pp. 115 - 123 |
|---|---|
| Main Authors: | , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Elsevier B.V
01-06-2014
SpringerOpen |
| Subjects: | |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | To compare between gestagen versus oral contraceptive pills to induce withdrawal bleeding before induction of ovulation by clomiphene citrate in polycystic ovary syndrome.
Randomized controlled trial.
Integrated Fertility Center and Agial Fertility Center.
Fifty PCO female patients.
The patients were subdivided in 2 groups according to computer generated randomized program:
Group I: Twenty five PCO female patients treated by cidolut nor 5mg tablets (two tablets every day for 5days).
Group II: Twenty five PCO female patients treated by cilest tablets (one tablet every day for 21days).
All patients were observed until withdrawal bleeding followed by ovulation induction by clomiphene citrate from the second day of menses (100mg per day for 5days). The patients were then followed up by:
-transvaginal ultrasound follicular scanning in days 10, 12, and 14 of withdrawal bleeding until ovulation was detected with additional evaluation of the endometrial thickness and pattern-serum progesterone was measured 7days after the expected day of ovulation-pregnancy test 15days after ovulation to detect pregnancy and 2weeks later by U/S to detect fetal pulsation.
Endometrial thickness, number of mature follicles and serum progesterone level on day o f ovulation, and clinical pregnancy rate.
There was no significant difference between the two groups regarding pregnancy rate.
A few studies show an apparent use of oral contraceptive pills in the improvement of ovulation induction by clomiphene citrate. Despite this, from the available data a causal relationship is not confirmed, so large prospective studies using larger sample size, and longer duration of treatment are needed. Meanwhile, close clinical surveillance of patients being treated with oral contraceptive pills is required. |
|---|---|
| ISSN: | 1110-5690 |
| DOI: | 10.1016/j.mefs.2013.06.003 |