Search Results - "Elsaid, Khaled"
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Fingolimod Phosphate (FTY720-P) Activates Protein Phosphatase 2A in Human Monocytes and Inhibits Monosodium Urate Crystal-Induced Interleukin-1 β Production
Published in The Journal of pharmacology and experimental therapeutics (01-02-2021)“…Gout is a chronic inflammatory arthritis caused by monosodium urate monohydrate (MSU) crystal deposits in joints of lower limbs. Phagocytic uptake of MSU…”
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Role of CD44 in Regulating TLR2 Activation of Human Macrophages and Downstream Expression of Proinflammatory Cytokines
Published in The Journal of immunology (1950) (15-01-2018)“…Osteoarthritis (OA) is a low-grade chronic inflammatory joint disease. Innate immunity contributes to OA progression, mediated by TLR2 and TLR4. We evaluated…”
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3
Application of nanofluids for enhanced waste heat recovery: A review
Published in Nano energy (01-06-2021)“…Heat is the most common form of energy either in final or intermediate forms, with the latter enabling energy conversion to other useful forms. Heat is…”
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Protein phosphatase 2A regulates xanthine oxidase-derived ROS production in macrophages and influx of inflammatory monocytes in a murine gout model
Published in Frontiers in pharmacology (17-11-2022)“…Background: Gout is a common arthritis, due to deposition of monosodium urate (MSU) crystals which results in IL-1β secretion by tissue-resident macrophages…”
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CD44 Receptor Mediates Urate Crystal Phagocytosis by Macrophages and Regulates Inflammation in A Murine Peritoneal Model of Acute Gout
Published in Scientific reports (01-04-2020)“…Gout is a chronic arthritis caused by the deposition of poorly soluble monosodium urate monohydrate (MSU) crystals in peripheral joints. Resident macrophages…”
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The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes
Published in Arthritis research & therapy (08-05-2017)“…Lubricin/proteoglycan 4 (PRG4) is a mucinous glycoprotein secreted by synovial fibroblasts and superficial zone chondrocytes. Recently, we showed that…”
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All Transition Metal Selenide Composed High‐Energy Solid‐State Hybrid Supercapacitor
Published in Small (Weinheim an der Bergstrasse, Germany) (01-05-2022)“…Transition metal selenides (TMSs) have enthused snowballing research and industrial attention due to their exclusive conductivity and redox activity features,…”
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8
Role of lubricin and boundary lubrication in the prevention of chondrocyte apoptosis
Published in Proceedings of the National Academy of Sciences - PNAS (09-04-2013)“…Osteoarthritis is a complex disease involving the mechanical breakdown of articular cartilage in the presence of altered joint mechanics and chondrocyte death,…”
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9
Selection Guidelines for Wind Energy Technologies
Published in Energies (Basel) (01-06-2021)“…The building block of all economies across the world is subject to the medium in which energy is harnessed. Renewable energy is currently one of the…”
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Evaluating the efficacy of AI content detection tools in differentiating between human and AI-generated text
Published in International Journal for Educational Integrity (01-09-2023)“…The proliferation of artificial intelligence (AI)-generated content, particularly from models like ChatGPT, presents potential challenges to academic integrity…”
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Prospects of Fuel Cell Combined Heat and Power Systems
Published in Energies (Basel) (01-08-2020)“…Combined heat and power (CHP) in a single and integrated device is concurrent or synchronized production of many sources of usable power, typically electric,…”
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Cu2O nanoparticles decorated with MoS2 sheets for electrochemical reduction of CO2 with enhanced efficiency
Published in Applied physics. A, Materials science & processing (01-02-2022)“…Electrochemical CO 2 reduction has drawn substantial attention not only due to the demand for energy but also the need for a sustainable environment. In this…”
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Lubricin/Proteoglycan 4 Binding to CD44 Receptor: A Mechanism of the Suppression of Proinflammatory Cytokine–Induced Synoviocyte Proliferation by Lubricin
Published in Arthritis & rheumatology (Hoboken, N.J.) (01-06-2015)“…Objective To evaluate the binding of recombinant human proteoglycan 4 (rhPRG4) to CD44 receptor and its consequences on cytokine‐induced synoviocyte…”
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Theoretical and experimental investigations of Co-Cu bimetallic alloys-incorporated carbon nanowires as an efficient bi-functional electrocatalyst for water splitting
Published in Journal of industrial and engineering chemistry (Seoul, Korea) (25-04-2021)“…[Display omitted] Application of noble metal-free electrocatalysts for oxygen evolution reaction (OER) and hydrogen evolution reaction (HER) during…”
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Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration
Published in Arthritis research & therapy (14-09-2021)“…Synovial macrophages perform a multitude of functions that include clearance of cell debris and foreign bodies, tissue immune surveillance, and resolution of…”
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Proteoglycan-4 regulates fibroblast to myofibroblast transition and expression of fibrotic genes in the synovium
Published in Arthritis research & therapy (13-05-2020)“…Synovial tissue fibrosis is common in advanced OA with features including the presence of stress fiber-positive myofibroblasts and deposition of cross-linked…”
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Animal Models of Osteoarthritis: Challenges of Model Selection and Analysis
Published in The AAPS journal (01-04-2013)“…ABSTRACT Osteoarthritis (OA) is the most common musculoskeletal disease, affecting millions of individuals worldwide. New treatment approaches require an…”
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Recent progress in renewable energy based-desalination in the Middle East and North Africa MENA region
Published in Journal of advanced research (01-06-2023)“…[Display omitted] •Availability of RES in the MENA region was summarized.•Suitable renewable energy storage systems in MENA was introduced.•Desalination plants…”
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Thermophysical properties of graphene-based nanofluids
Published in International Journal of Thermofluids (01-05-2021)“…•Nanofluids have enhanced thermophysical properties with improved heat transfer efficiency.•Graphene-based nanofluids have an outstanding thermal…”
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Design and Biological Evaluation of Colchicine-CD44-Targeted Peptide Conjugate in an In Vitro Model of Crystal Induced Inflammation
Published in Molecules (Basel, Switzerland) (21-12-2019)“…Gout is an inflammatory arthritis due to the joint deposition of monosodium urate (MSU) crystals. Phagocytosis of MSU crystals by tissue macrophages results in…”
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