Search Results - "Elsadek, Bakheet E. M."

Design, synthesis and mechanistic study of N-4-Piperazinyl Butyryl Thiazolidinedione derivatives of ciprofloxacin with Anticancer Activity via Topoisomerase I/II inhibition by Aziz, Hossameldin A., El-Saghier, Ahmed M., badr, Mohamed, Elsadek, Bakheet E. M., Abuo-Rahma, Gamal El-Din A., Shoman, Mai E.

“…A new group of thiazolidine-2,4-dione derivatives of ciprofloxacin having butyryl linker 3a-l was synthesized via an alkylation of thiazolidine-2,4-diones with…”
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Tolmetin Sodium Fast Dissolving Tablets for Rheumatoid Arthritis Treatment: Preparation and Optimization Using Box-Behnken Design and Response Surface Methodology by Elsayed, Mahmoud M A, Aboelez, Moustafa O, Elsadek, Bakheet E M, Sarhan, Hatem A, Khaled, Khaled Ali, Belal, Amany, Khames, Ahmed, Hassan, Yasser A, Abdel-Rheem, Amany A, Elkaeed, Eslam B, Raafat, Mohamed, Elsadek, Mahmoud Elkot Mostafa

“…Tolmetin sodium (TLM) is a non-steroidal anti-inflammatory drug (NSAIDs). TLM is used to treat inflammation, skeletal muscle injuries, and discomfort…”
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Hydroxycitric acid potentiates the cytotoxic effect of tamoxifen in MCF-7 breast cancer cells through inhibition of ATP citrate lyase by Ismail, Ahmed, Doghish, Ahmed S., E. M. Elsadek, Bakheet, Salama, Salama A., Mariee, Amr D.

“…•Metabolic reprogramming plays a role in cancer progression and treatment response.•Tamoxifen regulates the expression of lipid metabolizing…”
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Androgen/androgen receptor affects gentamicin-induced nephrotoxicity through regulation of megalin expression by Elsakka, Elsayed G.E., Elsisi, Ahmad Mohamed, Mansour, Osama Abd Al-Motaal, Elsadek, Bakheet E.M., Abd Elaziz, Adel I., Salama, Salama Abdou, Allam, Shady

“…Investigation whether androgen/androgen receptor (AR) might regulate megalin expression and/or functionality and thus affecting Gentamicin-induced…”
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Vitamin D Receptor Gene Polymorphisms and Risk of Knee Osteoarthritis: Possible Correlations with TNF-α, Macrophage Migration Inhibitory Factor, and 25-Hydroxycholecalciferol Status by Hassan, Mohammed H., Elsadek, Amer Alkot Mostafa, Mahmoud, Marwa Ahmed, Elsadek, Bakheet E. M.

“…Osteoarthritis (OA) etiology and pathogenesis not yet fully understood. We studied the role of vitamin D receptor single-nucleotide polymorphisms (VDR-SNPs),…”
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The effect of aryl hydrocarbon receptor ligands on gentamicin-induced nephrotoxicity in rats by Mokhtar, Mahmoud Mohamed, Khidr, Emad Gamil, Shaban, Hesham Mohamed, Allam, Shady, Elsadek, Bakheet E. M., Salama, Salama Abdou, Ali, Shawkey Saddik

“…Polycyclic aromatic hydrocarbons (PAHs)/aryl hydrocarbon receptor (AhR) regulate the expression of target genes, including drug transporter genes which harbor…”
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Ceiba pentandra ethyl acetate extract improves doxorubicin antitumor outcomes against chemically induced liver cancer in rat model: a study supported by UHPLC-Q-TOF-MS/MS identification of the bioactive phytomolecules by Orabi, Mohamed A A, Abouelela, Mohamed E, Darwish, Faten M M, Abdelkader, Mohamed S A, Elsadek, Bakheet E M, Al Awadh, Ahmed Abdullah, Alshahrani, Mohammed Merae, Alhasaniah, Abdulaziz Hassan, Aldabaan, Nayef, Abdelhamid, Reda A

“…Hepatocellular carcinoma (HCC) is a prevalent cancer worldwide. Late-stage detection, ineffective treatments, and tumor recurrence contribute to the low…”
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Validation of the Diagnostic and Prognostic Values of ADAMTS5 and FSTL1 in Osteoarthritis Rat Model by Elsadek, Bakheet E. M., Abdelghany, Ahmed A., Abd EL-Aziz, Mohamed A., Madkor, Hafez R., Abd Elrady Ahmed, Ahmed, Abd-Elghaffar, Sary Kh, Elsadek, Amer Alkot Mostafa

“…Objective Osteoarthritis (OA) is a global public health problem and a leading cause of morbidity and disability. Due to lack of sensitive and specific tools…”
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Circulating Ubiquitin Carboxyl Terminal Hydrolase L1 and Neuroglobin Levels in Traumatic Spinal Cord Injuries: Relation to Severity and Outcomes by Abuhamdah, Sawsan, Saleem, Tahia H, Elsadek, Bakheet E.M, Ashraf, Omyma, Hamdan, Ali R, El-Khateeb, Eslam El Sayed, Elwahab, Saeda M. Abd, Hassan, Mohammed H

“…Introduction: Traumatic spinal cord injury (TSCI) is a life-threatening neurological disorder and there is a lack of biomarker research, particularly human…”
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Zinc oxide nanoparticles as a novel anticancer approach; in vitro and in vivo evidence by Hassan, Hesham Fathy Hassan, Mansour, Ahmed Mohamed, Abo‐Youssef, Amira Morad Hussein, Elsadek, Bakheet E M, Messiha, Basim Anwar Shehata

“…Summary Currently, the outcomes of conventional chemotherapeutic approaches are unsatisfactory. Clinical application of nanoparticles seems promising. We aim…”
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Estrogen/estrogen receptor activation protects against DEN-induced liver fibrosis in female rats via modulating TLR-4/NF-kβ signaling by Eisa, Mahmoud A, Mansour, Ahmed M, Salama, Salama A, Elsadek, Bakheet E M, Ashour, Ahmed A, Abdelghany, Tamer M

“…Men are more susceptible to liver fibrosis (LF) than women. However, the underlying molecular mechanism, especially the role of estrogen/estrogen receptor (ER)…”
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Pioglitazone ameliorates high fat diet-induced hypertension and induces catechol o-methyl transferase expression in rats by Hegazy, Maghawry, El-Shafey, Mostafa, Abulsoud, Ahmed Ibrahim, Elsadek, Bakheet E.M., Abd Elaziz, Adel I., Salama, Salama Abdou

“…Our study aimed to investigate the effect of pioglitazone (PIO) on the obesity-associated metabolic effects and whether this effect is associated with…”
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Design, synthesis and pharmacophoric model building of new 3‐alkoxymethyl/3‐phenyl indole‐2‐carboxamides with potential antiproliferative activity by Abdelrahman, Mostafa H., Aboraia, Ahmed S., Youssif, Bahaa G. M., Elsadek, Bakheet E. M.

“…Novel 3‐alkoxymethyl/3‐phenyl indole‐2‐carboxamide derivatives were synthesized and evaluated for their anticancer activity. Most of the tested compounds…”
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Estrogen Attenuates Diethylnitrosamine-Induced Hepatocellular Carcinoma in Female Rats via Modulation of Estrogen Receptor/FASN/CD36/IL-6 Axis by Abdel-Hamid, Mohammed S., Mansour, Ahmed M., Hassan, Memy H., Abdelhady, Rasha, Elsadek, Bakheet E.M., El-Sayed, El-Sayed M., Salama, Salama A

“…This study was designed to evaluate the potential protective impact of estrogen and estrogen receptor against diethylnitrosamine (DEN)-induced hepatocellular…”
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Utilization of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinone as a cap moiety in design of novel histone deacetylase inhibitors by Mohamed, Mamdouh F.A., Youssif, Bahaa G.M., Shaykoon, Montaser Sh. A., Abdelrahman, Mostafa H., Elsadek, Bakheet E.M., Aboraia, Ahmed S., Abuo-Rahma, Gamal El-Din A.

“…[Display omitted] •12 novel compounds contain Tetrahydrobenzo[4,5]Thieno[2,3-d]pyrimidinone as a novel cap group, attached to ZBG via aliphatic, aralkyl or…”
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Design, synthesis, docking studies and biological evaluation of novel chalcone derivatives as potential histone deacetylase inhibitors by Mohamed, Mamdouh F.A., Shaykoon, Montaser Sh.A., Abdelrahman, Mostafa H., Elsadek, Bakheet E.M., Aboraia, Ahmed S., Abuo-Rahma, Gamal El-Din A.A.

“…[Display omitted] •Chalcone derivatives comprising hydroxamic acids or 2-aminobenzamide as zinc binding groups.•Anti-proliferative activity against human…”
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Circulating and local nuclear expression of survivin and fibulin-3 genes in discriminating benign from malignant respiratory diseases: correlation analysis by Hassan, Mohammed H, Abuhamdah, Sawsan, Abdel-Bary, Mohamed, Wahman, Mohammed, Abd-Elhamid, Tarek Hamdy, Beshay, Morris, Mosallam, Karam, Elsadek, Bakheet E M

“…Survivin is an inhibitor of apoptosis as well as a promoter of cell proliferation. Fibulin-3 is a matrix glycoprotein that displays potential for tumor…”
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Screening for new peptide substrates for the development of albumin binding anticancer pro-drugs that are cleaved by prostate-specific antigen (PSA) to improve the anti tumor efficacy by Elsadek, Bakheet E.M., Hassan, Mohammed H.

“…Several attempts have been made over the past decade to explore the concept of prodrug strategies that exploit PSA as a molecular target for the release of…”
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Ethyl acetate extract of Ceiba pentandra (L.) Gaertn. reduces methotrexate-induced renal damage in rats via antioxidant, anti-inflammatory, and antiapoptotic actions by Abouelela, Mohamed E., Orabi, Mohamed A.A., Abdelhamid, Reda A., Abdelkader, Mohamed S., Madkor, Hafez R., Darwish, Faten M.M., Hatano, Tsutomu, Elsadek, Bakheet E.M.

“…Methotrexate (MTX) is a chemotherapeutic agent and an immunosuppressant used to treat cancer and autoimmune diseases. However, its use is limited by its…”
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Lesional and circulating levels of interleukin‐17 and 25‐hydroxycholecalciferol in active acne vulgaris: Correlation to disease severity by Abd‐Elmaged, Wafaa M., Nada, Essam A., Hassan, Mohammed H., Elsadek, Bakheet E. M., Abdelrahim, Eman A., Ahmed, Nagwa S., Toghan, Rana, Ahmed, Heba T. I.

“…Summary Objectives The immunological aspects of inflammatory acne are still incompletely understood, so this study aimed to investigate the possible role of…”
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