Search Results - "Elsa Lauwers"

Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy by Uytterhoeven, Valerie, Lauwers, Elsa, Maes, Ine, Miskiewicz, Katarzyna, Melo, Manuel N., Swerts, Jef, Kuenen, Sabine, Wittocx, Rafaël, Corthout, Nikky, Marrink, Siewert-Jan, Munck, Sebastian, Verstreken, Patrik

“…Synapses are often far from their cell bodies and must largely independently cope with dysfunctional proteins resulting from synaptic activity and stress. To…”
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Synaptic mitochondria in synaptic transmission and organization of vesicle pools in health and disease by Vos, Melissa, Lauwers, Elsa, Verstreken, Patrik

“…Cell types rich in mitochondria, including neurons, display a high energy demand and a need for calcium buffering. The importance of mitochondria for proper…”
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In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters by Bademosi, Adekunle T., Lauwers, Elsa, Padmanabhan, Pranesh, Odierna, Lorenzo, Chai, Ye Jin, Papadopulos, Andreas, Goodhill, Geoffrey J., Verstreken, Patrik, van Swinderen, Bruno, Meunier, Frédéric A.

“…Syntaxin1A is organized in nanoclusters that are critical for the docking and priming of secretory vesicles from neurosecretory cells. Whether and how these…”
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Trapping of Syntaxin1a in Presynaptic Nanoclusters by a Clinically Relevant General Anesthetic by Bademosi, Adekunle T., Steeves, James, Karunanithi, Shanker, Zalucki, Oressia H., Gormal, Rachel S., Liu, Shu, Lauwers, Elsa, Verstreken, Patrik, Anggono, Victor, Meunier, Frederic A., van Swinderen, Bruno

“…Propofol is the most commonly used general anesthetic in humans. Our understanding of its mechanism of action has focused on its capacity to potentiate…”
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Improving the Aromatic Profile of Plant-Based Meat Alternatives: Effect of Myoglobin Addition on Volatiles by Devaere, Jolien, De Winne, Ann, Dewulf, Lore, Fraeye, Ilse, olji?, Irena, Lauwers, Elsa, de Jong, Andy, Sanctorum, Hermes

“…Market demand for palatable plant-based meat alternatives is on the rise. One of the challenges is formulating products with sensorial characteristics similar…”
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Evidence for coupled biogenesis of yeast Gap1 permease and sphingolipids: essential role in transport activity and normal control by ubiquitination by Lauwers, Elsa, Grossmann, Guido, André, Bruno

“…Current models for plasma membrane organization integrate the emerging concepts that membrane proteins tightly associate with surrounding lipids and that…”
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Correction: Publisher Correction: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters by Bademosi, Adekunle T., Lauwers, Elsa, Padmanabhan, Pranesh, Odierna, Lorenzo, Chai, Ye Jin, Papadopulos, Andreas, Goodhill, Geoffrey J., Verstreken, Patrik, van Swinderen, Bruno, Meunier, Frédéric A.

“…Nature Communications 7: Article number: 13660 (2016); Published: 16 December 2016; Updated: 10 April 2018 The original HTML version of this Article had an…”
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Systematic mutational analysis of the intracellular regions of yeast Gap1 permease by Merhi, Ahmad, Gérard, Nicolas, Lauwers, Elsa, Prévost, Martine, André, Bruno

“…The yeast general amino acid permease Gap1 is a convenient model for studying the intracellular trafficking of membrane proteins. Present at the plasma…”
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Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/β-catenin pathway in a Drosophila model for intellectual disability by Vandewalle, Joke, Langen, Marion, Zschätzsch, Marlen, Zschaetzsch, Marlen, Nijhof, Bonnie, Kramer, Jamie M, Brems, Hilde, Bauters, Marijke, Lauwers, Elsa, Srahna, Mohammed, Marynen, Peter, Verstreken, Patrik, Schenck, Annette, Hassan, Bassem A, Froyen, Guy

“…We recently reported that duplication of the E3 ubiquitin ligase HUWE1 results in intellectual disability (ID) in male patients. However, the underlying…”
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Erratum: In vivo single-molecule imaging of syntaxin1A reveals polyphosphoinositide- and activity-dependent trapping in presynaptic nanoclusters by Bademosi, Adekunle T., Lauwers, Elsa, Padmanabhan, Pranesh, Odierna, Lorenzo, Chai, Ye Jin, Papadopulos, Andreas, Goodhill, Geoffrey J., Verstreken, Patrik, van Swinderen, Bruno, Meunier, Frédéric A

“…Nature Communications 7: Article number: 13660 (2016); Published: 16 December 2016; Updated: 9 February 2017 This Article was originally published with an…”
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Membrane Lipids in Presynaptic Function and Disease by Lauwers, Elsa, Goodchild, Rose, Verstreken, Patrik

“…Lipids are the most abundant organic compounds in the brain. The brain has a unique lipidome, and changes in lipid concentration, organization, and metabolism…”
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Assaying Mutants of Clathrin-Mediated Endocytosis in the Fly Eye by Lauwers, Elsa, Verstreken, Patrik

“…Clathrin-mediated endocytosis plays essential roles both during and after development, and loss-of-function mutants affected in this process are mostly not…”
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Dementia and COVID-19: a health and research funding crisis by Aerts, Liesbeth, Lauwers, Elsa, De Strooper, Bart

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Presynaptic protein homeostasis and neuronal function by Wang, Yu-Chun, Lauwers, Elsa, Verstreken, Patrik

“…Proteome integrity is maintained by a coordinated network of molecular chaperones, by protein degradation machineries and by their regulators. Numerous human…”
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Rhophilin-2 is targeted to late-endosomal structures of the vesicular machinery in the presence of activated RhoB by Steuve, Séverine, Devosse, Thalie, Lauwers, Elsa, Vanderwinden, Jean-Marie, André, Bruno, Courtoy, Pierre J., Pirson, Isabelle

“…Rhophilin-2 or p76 RBE, a protein whose expression is induced by the cyclic AMP pathway in thyrocytes, contains several protein–protein interaction domains…”
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K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway by Lauwers, Elsa, Jacob, Christophe, André, Bruno

“…A growing number of yeast and mammalian plasma membrane proteins are reported to be modified with K63-linked ubiquitin (Ub) chains. However, the relative…”
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Neurodegeneration cell per cell by Balusu, Sriram, Praschberger, Roman, Lauwers, Elsa, De Strooper, Bart, Verstreken, Patrik

“…The clinical definition of neurodegenerative diseases is based on symptoms that reflect terminal damage of specific brain regions. This is misleading as it…”
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The ubiquitin code of yeast permease trafficking by Lauwers, Elsa, Erpapazoglou, Zoi, Haguenauer-Tsapis, Rosine, André, Bruno

“…Yeast permeases, that act as transporters for nutrients including amino acids, nucleobases and metals, provide a powerful model system for dissecting the…”
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Hsp90 Mediates Membrane Deformation and Exosome Release by Lauwers, Elsa, Wang, Yu-Chun, Gallardo, Rodrigo, Van der Kant, Rob, Michiels, Emiel, Swerts, Jef, Baatsen, Pieter, Zaiter, Samantha S., McAlpine, Shelli R., Gounko, Natalia V., Rousseau, Frederic, Schymkowitz, Joost, Verstreken, Patrik

“…Hsp90 is an essential chaperone that guards proteome integrity and amounts to 2% of cellular protein. We now find that Hsp90 also has the ability to directly…”
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Chaperoning the synapse-NMNAT protects Bruchpilot from crashing by Lauwers, Elsa, Verstreken, Patrik

“…Maintaining active zone structure is crucial for synaptic function. In this issue of EMBO reports , NMNAT is shown to act as a chaperone that protects the…”
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