Search Results - "Els, F"

Miro proteins coordinate microtubule‐ and actin‐dependent mitochondrial transport and distribution by López‐Doménech, Guillermo, Covill‐Cooke, Christian, Ivankovic, Davor, Halff, Els F, Sheehan, David F, Norkett, Rosalind, Birsa, Nicol, Kittler, Josef T

“…In the current model of mitochondrial trafficking, Miro1 and Miro2 Rho‐GTPases regulate mitochondrial transport along microtubules by linking mitochondria to…”
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Trace amine-associated receptor 1 (TAAR1) agonism as a new treatment strategy for schizophrenia and related disorders by Halff, Els F., Rutigliano, Grazia, Garcia-Hidalgo, Anna, Howes, Oliver D.

“…Schizophrenia remains a major health burden, highlighting the need for new treatment approaches. We consider the potential for targeting the trace amine (TA)…”
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Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats by Onwordi, Ellis Chika, Halff, Els F., Whitehurst, Thomas, Mansur, Ayla, Cotel, Marie-Caroline, Wells, Lisa, Creeney, Hannah, Bonsall, David, Rogdaki, Maria, Shatalina, Ekaterina, Reis Marques, Tiago, Rabiner, Eugenii A., Gunn, Roger N., Natesan, Sridhar, Vernon, Anthony C., Howes, Oliver D.

“…Synaptic dysfunction is hypothesised to play a key role in schizophrenia pathogenesis, but this has not been tested directly in vivo.  Here, we investigated…”
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Cryoelectron Tomography of the NAIP5/NLRC4 Inflammasome: Implications for NLR Activation by Diebolder, Christoph A., Halff, Els F., Koster, Abraham J., Huizinga, Eric G., Koning, Roman I.

“…Inflammasomes are high molecular weight protein complexes that play a crucial role in innate immunity by activating caspase-1. Inflammasome formation is…”
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Cdk5 and GSK3β inhibit fast endophilin-mediated endocytosis by Ferreira, Antonio P. A., Casamento, Alessandra, Carrillo Roas, Sara, Halff, Els F., Panambalana, James, Subramaniam, Shaan, Schützenhofer, Kira, Chan Wah Hak, Laura, McGourty, Kieran, Thalassinos, Konstantinos, Kittler, Josef T., Martinvalet, Denis, Boucrot, Emmanuel

“…Endocytosis mediates the cellular uptake of micronutrients and cell surface proteins. Fast Endophilin-mediated endocytosis, FEME, is not constitutively active…”
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SNX27-Mediated Recycling of Neuroligin-2 Regulates Inhibitory Signaling by Halff, Els F., Szulc, Blanka R., Lesept, Flavie, Kittler, Josef T.

“…GABAA receptors mediate fast inhibitory transmission in the brain, and their number can be rapidly up- or downregulated to alter synaptic strength…”
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Formation and Structure of a NAIP5-NLRC4 Inflammasome Induced by Direct Interactions with Conserved N- and C-terminal Regions of Flagellin by Halff, Els F., Diebolder, Christoph A., Versteeg, Marian, Schouten, Arie, Brondijk, T.Harma C., Huizinga, Eric G.

“…The NOD-like receptors NAIP5 and NLRC4 play an essential role in the innate immune response to the bacterial tail protein flagellin. Upon flagellin detection,…”
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Phosphorylation of neuroligin-2 by PKA regulates its cell surface abundance and synaptic stabilization by Halff, Els F, Hannan, Saad, Kwanthongdee, Jaturon, Lesept, Flavie, Smart, Trevor G, Kittler, Josef T

“…The trans-synaptic adhesion molecule neuroligin-2 (NL2) is essential for the development and function of inhibitory synapses. NL2 recruits the postsynaptic…”
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Myostatin-like proteins regulate synaptic function and neuronal morphology by Augustin, Hrvoje, McGourty, Kieran, Steinert, Joern R, Cochemé, Helena M, Adcott, Jennifer, Cabecinha, Melissa, Vincent, Alec, Halff, Els F, Kittler, Josef T, Boucrot, Emmanuel, Partridge, Linda

“…Growth factors of the TGFβ superfamily play key roles in regulating neuronal and muscle function. Myostatin (or GDF8) and GDF11 are potent negative regulators…”
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Effects of chronic exposure to haloperidol, olanzapine or lithium on SV2A and NLGN synaptic puncta in the rat frontal cortex by Halff, Els F., Cotel, Marie-Caroline, Natesan, Sridhar, McQuade, Richard, Ottley, Chris J., Srivastava, Deepak P., Howes, Oliver D., Vernon, Anthony C.

“…•SV2A-binding radiotracers assess synaptic density in human psychiatric disorder.•Separating illness from drug exposure effects on SV2A binding remains…”
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Telomere biology and its maintenance in schizophrenia spectrum disorders: Exploring links to cognition by Mlakar, Vid, Akkouh, Ibrahim, Halff, Els F., Srivastava, Deepak P., Birkenæs, Viktoria, Ueland, Torill, Quintana, Daniel S., Ormerod, Monica B.E.G., Steen, Nils Eiel, Djurovic, Srdjan, Andreassen, Ole A., Aas, Monica

“…Contemporary research suggests reduced telomere length in schizophrenia spectrum disorders (SZ) compared to age-adjusted non-affected individuals. However, the…”
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SARS-CoV-2 transmission risk in the school environment: A pilot case-ascertained prospective study to inform future school-based surveillance by Siegfried, N L, de Voux, A, Jonas, K, Yun, J A, Chetty, T, Mabona, M, Els, F, Mdose, H, Kuonza, L, Hsiao, M, Mathews, C

“…Background There is no current active or passive disease surveillance programme focused on schools in South Africa (SA). As such, the country is missing an…”
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Evaluation of Intraperitoneal [18F]-FDOPA Administration for Micro-PET Imaging in Mice and Assessment of the Effect of Subchronic Ketamine Dosing on Dopamine Synthesis Capacity by Halff, Els F., Natesan, Sridhar, Bonsall, David R., Veronese, Mattia, Garcia-Hidalgo, Anna, Kokkinou, Michelle, Tang, Sac-Pham, Riggall, Laura J., Gunn, Roger N., Irvine, Elaine E., Withers, Dominic J., Wells, Lisa A., Howes, Oliver D.

“…Positron emission tomography (PET) using the radiotracer [18F]-FDOPA provides a tool for studying brain dopamine synthesis capacity in animals and humans. We…”
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Correction: Sub-Chronic Ketamine Administration Increases Dopamine Synthesis Capacity in the Mouse Midbrain: a Preclinical In Vivo PET Study by Petty, Alice, Garcia-Hidalgo, Anna, Halff, Els F., Natesan, Sridhar, Withers, Dominic J., Irvine, Elaine E., Kokkinou, Michelle, Wells, Lisa A., Bonsall, David R., Tang, Sac-Pham, Veronese, Mattia, Howes, Oliver D.

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Structure of Compstatin in Complex with Complement Component C3c Reveals a New Mechanism of Complement Inhibition by Janssen, Bert J.C., Halff, Els F., Lambris, John D., Gros, Piet

“…Undesired complement activation is a major cause of tissue injury in various pathological conditions and contributes to several immune complex diseases…”
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Sub-Chronic Ketamine Administration Increases Dopamine Synthesis Capacity in the Mouse Midbrain: a Preclinical In Vivo PET Study by Petty, Alice, Garcia-Hidalgo, Anna, Halff, Els F, Natesan, Sridhar, Withers, Dominic J, Irvine, Elaine E, Kokkinou, Michelle, Wells, Lisa A, Bonsall, David R, Tang, Sac-Pham, Veronese, Mattia, Howes, Oliver D

“…Purpose There is robust evidence that people with schizophrenia show elevated dopamine (DA) synthesis capacity in the striatum. This finding comes from…”
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The prevalence and distribution of malaria in Mpumalanga Province before and during COVID-19 (2017 - 2022) by Kleinhans, I, Mahanjana, S, Els, F, Mabona, M, Pitso, L A, Malatje, G, Kok, G, Raman, J

“…\r\nBackground\r\nSouth Africa (SA) has committed to eliminating malaria by 2028. However, the initial target was set for 2023. Additionally, the ongoing…”
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Provenancing of unidentified World War II casualties: Application of strontium and oxygen isotope analysis in tooth enamel by Font, Laura, Jonker, Geert, van Aalderen, Patric A, Schiltmans, Els F, Davies, Gareth R

“…Abstract In 2010 and 2012 two sets of unidentified human remains of two World War II soldiers were recovered in the area where the 1944–1945 Kapelsche Veer…”
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When less becomes more: Optimization of protein expression in HEK293–EBNA1 cells using plasmid titration – A case study for NLRs by Halff, Els F., Versteeg, Marian, Brondijk, T. Harma C., Huizinga, Eric G.

“…•A subset of proteins aggregate upon transient expression in HEK293E cells.•This may be caused by the high expression levels achieved by this system.•Plasmid…”
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Favourable outcome in a child with symptomatic diagnosis of Glutaric aciduria type 1 despite vertical HIV infection and minor head trauma by Thomas, Angeline, Dobbels, Els F. M., Springer, Priscilla E., Ackermann, Christelle, Cotton, Mark F., Laughton, Barbara

“…The first case of Glutaric aciduria Type 1(GA1) in an African child was reported in 2001. GA1 has a prevalence of 1:5000 in black South Africans. Although…”
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