Search Results - "Elrod, K C"

Perspectives on factor Xa inhibition by Rai, R, Sprengeler, P A, Elrod, K C, Young, W B

“…Blood coagulation involves a complex cascade of enzymatic reactions, ultimately generating fibrin, the basis of all blood clots. This cascade is comprised of…”
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Lactoferrin, a potent tryptase inhibitor, abolishes late-phase airway responses in allergic sheep by ELROD, K. C, MOORE, W. R, ABRAHAM, W. M, TANAKA, R. D

“…Tryptase, a serine protease released exclusively from activated mast cells, has been implicated as a potential causative agent in asthma. Enzymatically active…”
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High-Throughput Screening of Enzyme Inhibitors: Simultaneous Determination of Tight-Binding Inhibition Constants and Enzyme Concentration by Kuzmič, Petr, Elrod, Kyle C, Cregar, Lynne M, Sideris, Steve, Rai, Roopa, Janc, James W

“…Active site titration by a reversible tight-binding inhibitor normally depends on prior knowledge of the inhibition constant. Conversely, the determination of…”
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Neutrophil Myeloperoxidase Is a Potent and Selective Inhibitor of Mast Cell Tryptase by Cregar, Lynne, Elrod, Kyle C., Putnam, Daun, Moore, William R.

“…Myeloperoxidase (MPO) is an important component of the neutrophil response to microbial infection. In this paper we report an additional activity of MPO, the…”
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A Novel Approach to Serine Protease Inhibition:  Kinetic Characterization of Inhibitors Whose Potencies and Selectivities Are Dramatically Enhanced by Zinc(II) by Janc, James W, Clark, James M, Warne, Robert L, Elrod, Kyle C, Katz, Bradley A, Moore, William R

“…Serine proteases play a role in a variety of disease states and thus are attractive targets for therapeutic intervention. We report the kinetic…”
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Metal mediated protease inhibition: design and synthesis of inhibitors of the human cytomegalovirus (hCMV) protease by Dhanak, Dashyant, Burton, George, Christmann, Lisa T, Darcy, Michael G, Elrod, Kyle C, Kaura, Arun, Keenan, Richard M, Link, John O, Peishoff, Catherine E, Shah, Dinubhai H

“…A versatile synthetic route to a novel series of bis-imidazolemethanes designed to inhibit the hCMV protease has been developed and a series of potential metal…”
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Expression and Characterization of Recombinant Mast Cell Tryptase by Chan, Hedy, Elrod, Kyle C., Numerof, Robert P., Sideris, Steve, Clark, James M.

“…Tryptase, a serine protease, is the major protein component in mast cells. In an animal model of asthma, tryptase has been established as an important mediator…”
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High-Throughput Screening of Enzyme Inhibitors: Automatic Determination of Tight-Binding Inhibition Constants by Kuzmič, Petr, Sideris, Steve, Cregar, Lynne M., Elrod, Kyle C., Rice, Kenneth D., Janc, James W.

“…Determination of tight-binding inhibition constants by nonlinear least-squares regression requires sufficiently good initial estimates of the best-fit values…”
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Factor VIIa inhibitors: Chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model by Young, Wendy B., Mordenti, Joyce, Torkelson, Steven, Shrader, William D., Kolesnikov, Aleksandr, Rai, Roopa, Liu, Liang, Hu, Huiyong, Leahy, Ellen M., Green, Michael J., Sprengeler, Paul A., Katz, Bradley A., Yu, Christine, Janc, James W., Elrod, Kyle C., Marzec, Ulla M., Hanson, Stephen R.

“…Highly selective and potent factor VIIa–tissue factor (fVIIa · TF) complex inhibitors were generated through structure-based design. The pharmacokinetic…”
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Potent bivalent inhibition of human tryptase-beta by a synthetic inhibitor by Selwood, Trevor, Elrod, Kyle C, Schechter, Norman M

“…Human tryptase-beta (HTbeta) is a unique serine protease exhibiting a frame-like tetramer structure with four active sites directed toward a central pore…”
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Small molecule inhibitors of plasma kallikrein by Young, Wendy B., Rai, Roopa, Shrader, William D., Burgess-Henry, Jana, Hu, Huiyong, Elrod, Kyle C., Sprengeler, Paul A., Katz, Bradley A., Sukbuntherng, Juthamas, Mordenti, Joyce

“…Plasma kallikrein is a serine protease that is involved in pathways of inflammation, complement fixation, coagulation, and fibrinolysis. Herein, we describe…”
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Expression, purification, crystallization and preliminary X-ray diffraction studies of human cathepsin F complexed with an irreversible vinyl sulfone inhibitor by Ho, Joseph D., Meltser, Yana, Buggy, Joseph J., Palmer, James T., Elrod, Kyle C., Chan, Hedy, Mortara, Kyle D., Somoza, John R.

“…Cathepsin F is a cysteine protease believed to be involved in the antigen‐presenting process of the class II major histocompatibility complex (MHC‐II) in…”
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