Search Results - "Elrod, Elizabeth"

Alterations in Intestinal Microbiota Lead to Production of Interleukin 17 by Intrahepatic γδ T-Cell Receptor–Positive Cells and Pathogenesis of Cholestatic Liver Disease by Tedesco, Dana, Thapa, Manoj, Chin, Chui Yoke, Ge, Yong, Gong, Minghao, Li, Jing, Gumber, Sanjeev, Speck, Patrick, Elrod, Elizabeth J., Burd, Eileen M., Kitchens, William H., Magliocca, Joseph F., Adams, Andrew B., Weiss, David S., Mohamadzadeh, Mansour, Grakoui, Arash

“…Variants at the ABCB4 or MDR2 locus, which encodes a biliary transport protein, are associated with a spectrum of cholestatic liver diseases. Exacerbation of…”
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Regions of hepatitis C virus E2 required for membrane association by Kumar, Ashish, Rohe, Tiana C., Elrod, Elizabeth J., Khan, Abdul G., Dearborn, Altaira D., Kissinger, Ryan, Grakoui, Arash, Marcotrigiano, Joseph

“…Hepatitis C virus (HCV) uses a hybrid entry mechanism. Current structural data suggest that upon exposure to low pH and Cluster of Differentiation 81 (CD81),…”
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Structural and functional insights into alphavirus polyprotein processing and pathogenesis by Shin, Gyehwa, Yost, Samantha A, Miller, Matthew T, Elrod, Elizabeth J, Grakoui, Arash, Marcotrigiano, Joseph

“…Alphaviruses, a group of positive-sense RNA viruses, are globally distributed arboviruses capable of causing rash, arthritis, encephalitis, and death in…”
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Hepatic stellate cells preferentially induce Foxp3+ regulatory T cells by production of retinoic acid by Dunham, Richard M, Thapa, Manoj, Velazquez, Victoria M, Elrod, Elizabeth J, Denning, Timothy L, Pulendran, Bali, Grakoui, Arash

“…The liver has long been described as immunosuppressive, although the mechanisms underlying this phenomenon are incompletely understood. Hepatic stellate cells…”
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Blockade of BAFF Reshapes the Hepatic B Cell Receptor Repertoire and Attenuates Autoantibody Production in Cholestatic Liver Disease by Thapa, Manoj, Tedesco, Dana, Gumber, Sanjeev, Elrod, Elizabeth J, Han, Jin-Hwan, Kitchens, William H, Magliocca, Joseph F, Adams, Andrew B, Grakoui, Arash

“…Defects in biliary transport proteins, MDR3 in humans and Mdr2 in mice, can lead to a spectrum of cholestatic liver disorders. Although B cell disorders and…”
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Liver fibrosis occurs through dysregulation of MyD88‐dependent innate B‐cell activity by Thapa, Manoj, Chinnadurai, Raghavan, Velazquez, Victoria M., Tedesco, Dana, Elrod, Elizabeth, Han, Jin‐Hwan, Sharma, Prachi, Ibegbu, Chris, Gewirtz, Andrew, Anania, Frank, Pulendran, Bali, Suthar, Mehul S., Grakoui, Arash

“…Chronic liver disease mediated by activation of hepatic stellate cells (HSCs) leads to liver fibrosis. Here, we postulated that the immune regulatory…”
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Novel E2 Glycoprotein Tetramer Detects Hepatitis C Virus-Specific Memory B Cells by Boisvert, Maude, Zhang, Wanrui, Elrod, Elizabeth J, Bernard, Nicole F, Villeneuve, Jean-Pierre, Bruneau, Julie, Marcotrigiano, Joseph, Shoukry, Naglaa H, Grakoui, Arash

“…Acute hepatitis C virus (HCV) infection culminates in viral persistence in the majority of cases. Abs that recognize the envelope glycoproteins E1 and E2 are…”
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Identification of cis-Acting Nucleotides and a Structural Feature in West Nile Virus 3′-Terminus RNA That Facilitate Viral Minus Strand RNA Synthesis by Davis, William G, Basu, Mausumi, Elrod, Elizabeth J, Germann, Markus W, Brinton, Margo A

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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CD4+Foxp3+ T cells promote aberrant immunoglobulin G production and maintain CD8+ T‐cell suppression during chronic liver disease by Tedesco, Dana, Thapa, Manoj, Gumber, Sanjeev, Elrod, Elizabeth J., Rahman, Khalidur, Ibegbu, Chris C., Magliocca, Joseph F., Adams, Andrew B., Anania, Frank, Grakoui, Arash

“…Persistent hepatotropic viral infections are a common etiologic agent of chronic liver disease. Unresolved infection can be attributed to nonfunctional…”
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CD4 + and CD8 + T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment by Kar, Meenakshi, Johnson, Katherine E E, Vanderheiden, Abigail, Elrod, Elizabeth J, Floyd, Katharine, Geerling, Elizabeth, Stone, E Taylor, Salinas, Eduardo, Banakis, Stephanie, Wang, Wei, Sathish, Shruti, Shrihari, Swathi, Davis-Gardner, Meredith E, Kohlmeier, Jacob, Pinto, Amelia, Klein, Robyn, Grakoui, Arash, Ghedin, Elodie, Suthar, Mehul S

“…SARS-CoV-2 infection induces the generation of virus-specific CD4 and CD8 effector and memory T cells. However, the contribution of T cells in controlling…”
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A neutralization epitope in the hepatitis C virus E2 glycoprotein interacts with host entry factor CD81 by Zhao, Zhong, Zhong, Lilin, Elrod, Elizabeth, Struble, Evi, Ma, Li, Yan, Hailing, Harman, Christine, Deng, Lu, Virata-Theimer, Maria Luisa, Liu, Peter, Alter, Harvey, Grakoui, Arash, Zhang, Pei

“…The identification of a specific immunogenic candidate that will effectively activate the appropriate pathway for neutralizing antibody production is…”
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Hyperfunctional T-cell responses unchecked by regulatory T cells are unable to resolve hepaciviral infection without humoral contribution by Jin, Fengzhi, Gridley, John, Kumari, Anuradha, Saeidi, Alireza, Holland, Brantley, Elrod, Elizabeth, Dravid, Piyush, Trivedi, Sheetal, Kapoor, Amit, Thapa, Manoj, Grakoui, Arash

“…The most recent T cell-based vaccine against HCV tested in humans failed to swing the pendulum from chronicity to resolution, despite eliciting cellular…”
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Concerted synergy between viral-specific IgG and CD8 + T cells is critical for clearance of an HCV-related rodent hepacivirus by Gridley, John, Holland, Brantley, Salinas, Eduardo, Trivedi, Sheetal, Dravid, Piyush, Elrod, Elizabeth, Jin, Fengzhi, Kumari, Anuradha, Batista, Mariana N, Thapa, Manoj, Rice, Charles M, Marcotrigiano, Joseph, Kapoor, Amit, Grakoui, Arash

“…Evidence assessing the role of B cells and their antibodies, or lack thereof, in the spontaneous resolution of acute HCV infection is conflicting. Utilization…”
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Neutralization and receptor use of infectious culture–derived rat hepacivirus as a model for HCV by Wolfisberg, Raphael, Thorselius, Caroline E., Salinas, Eduardo, Elrod, Elizabeth, Trivedi, Sheetal, Nielsen, Louise, Fahnøe, Ulrik, Kapoor, Amit, Grakoui, Arash, Rice, Charles M., Bukh, Jens, Holmbeck, Kenn, Scheel, Troels K. H.

“…Background and Aims Lack of tractable immunocompetent animal models amenable to robust experimental challenge impedes vaccine efforts for HCV. Infection with…”
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Blockade of B-cell activating factor (BAFF) reshapes the hepatic B cell receptor repertoire and attenuates autoantibody production in cholestatic liver disease by Thapa, Manoj, Tedesco, Dana, Gumber, Sanjeev, Elrod, Elizabeth J., Han, Jin-Hwan, Kitchen, William H., Magliocca, Joseph F., Adams, Andrew B., Grakoui, Arash

“…Defects in biliary transport proteins, MDR3 in humans and Mdr2 in mice, can lead to a spectrum of cholestatic liver disorders. Although B cell disorders and…”
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Chronic liver fibrosis triggers autoantibody production by B cells in a MyD88-dependent pathway (BA4P.126) by Thapa, Manoj, Tedesco, Dana, Elrod, Elizabeth, Han-Hwan, Jin, Grakoui, Arash

“…Our recent finding suggests that B cells contribute to liver fibrosis through hepatic stellate cells (HSCs) activation. While antibodies produced by the…”
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CD4+ Foxp3+ T cells promote aberrant IgG production and maintain CD8+ T cell suppression during chronic liver disease by Tedesco, Dana, Thapa, Manoj, Gumber, Sanjeev, Elrod, Elizabeth J., Rahman, Khalidur, Ibegbu, Chris C., Magliocca, Joseph F., Adams, Andrew B., Anania, Frank, Grakoui, Arash

“…Persistent hepatotropic viral infections are a common etiologic agent of chronic liver disease. Unresolved infection can be attributed to non-functional…”
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Novel E2 glycoprotein tetramer detects HCV-specific memory B cells1 by Boisvert, Maude, Zhang, Wanrui, Elrod, Elizabeth J., Bernard, Nicole F., Villeneuve, Jean-Pierre, Bruneau, Julie, Marcotrigiano, Joseph, Shoukry, Naglaa H., Grakoui, Arash

“…Acute hepatitis C virus (HCV 3 ) infection culminates in viral persistence in the majority of cases. Antibodies that recognize the envelope glycoproteins E1…”
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Host genetic factors and miRNA-linked dendritic cell responses associated with the outcome of treatment response in HIV-1/HCV co-infected individuals by Jain, Pooja, Sehgal, Mohit, Narang, Rubina, Ginwala, Rashida, Zeremski, Marija, Talal, Andrew, Elrod, Elizabeth, Grakoui, Arash, Li, Qi-Ging, Philip, Ramila, Khan, Zafar

“…HIV-1/HCV co-infection is a significant burden on global economy and public health. PEGylated interferon and ribavarin remain the essential components of…”
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IFN-α-Induced Downregulation of miR-221 in Dendritic Cells: Implications for HCV Pathogenesis and Treatment by Sehgal, Mohit, Zeremski, Marija, Talal, Andrew H, Ginwala, Rashida, Elrod, Elizabeth, Grakoui, Arash, Li, Qi-Ging, Philip, Ramila, Khan, Zafar K, Jain, Pooja

“…Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding…”
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