Search Results - "Elphick, Lucy"

Using Chemical Genetics and ATP Analogues To Dissect Protein Kinase Function by Elphick, Lucy M, Lee, Sarah E, Gouverneur, Véronique, Mann, David J

“…Protein kinases catalyze the transfer of the γ-phosphate of ATP to a protein substrate and thereby profoundly alter the properties of the phosphorylated…”
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Cyclin D1 and cyclin D3 show divergent responses to distinct mitogenic stimulation by Anderson, Alexandra A., Child, Emma S., Prasad, Aarathi, Elphick, Lucy M., Mann, David J.

“…D‐type cyclins predominantly regulate progression through the cell cycle by their interactions with cyclin‐dependent kinases (cdks). Here, we show that…”
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Synthesis and reactivity of novel γ-phosphate modified ATP analogues by Lee, Sarah E., Elphick, Lucy M., Anderson, Alexandra A., Bonnac, Laurent, Child, Emma S., Mann, David J., Gouverneur, Véronique

“…We hereby present a simple yet novel chemical synthesis of a family of γ-modified ATPs bearing functional groups on the γ-phosphate that are amenable to…”
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Synthesis and O-phosphorylation of 3,3,4,4-tetrafluoroaryl-C-nucleoside analogues by Bonnac, Laurent, Lee, Sarah E, Giuffredi, Guy T, Elphick, Lucy M, Anderson, Alexandra A, Child, Emma S, Mann, David J, Gouverneur, Véronique

“…Enantioenriched tetrafluorinated aryl-C-nucleosides were synthesised in four steps from 1-benzyloxy-4-bromo-3,3,4,4-tetrafluorobutan-2-ol. The presence of the…”
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Conserved valproic-acid-induced lipid droplet formation in Dictyostelium and human hepatocytes identifies structurally active compounds by Elphick, Lucy M, Pawolleck, Nadine, Guschina, Irina A, Chaieb, Leila, Eikel, Daniel, Nau, Heinz, Harwood, John L, Plant, Nick J, Williams, Robin S B

“…Lipid droplet formation and subsequent steatosis (the abnormal retention of lipids within a cell) has been reported to contribute to hepatotoxicity and is an…”
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Dose-dependent changes in cyclin D1 in response to 4-nitroquinoline 1-oxide-induced DNA damage by Suwaki, Natsuko, Child, Emma S, Elphick, Lucy M, Mann, David J

“…Cells respond to DNA damage by either repairing the damage or committing to a death or senescence pathway, dependent on the level of damage sustained. In this…”
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Opposing roles for caspase and calpain death proteases in l-glutamate-induced oxidative neurotoxicity by Elphick, Lucy M., Hawat, Mohammad, Toms, Nick J., Meinander, Annika, Mikhailov, Andrey, Eriksson, John E., Kass, George E.N.

“…Oxidative glutamate toxicity in HT22 murine hippocampal cells is a model for neuronal death by oxidative stress. We have investigated the role of proteases in…”
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Differential regulation of the cyclin-dependent kinase inhibitors p21(Cip1) and p27(Kip1) by phosphorylation directed by the cyclin encoded by Murine Herpesvirus 68 by Yarmishyn, Aliaksandr, Child, Emma S, Elphick, Lucy M, Mann, David J

“…Members of the gamma2-herpesvirus family encode cyclin-like proteins that have the ability to deregulate mammalian cell cycle control. Here we report the key…”
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Chemoselective One-Step Alkylation and Isolation of Thiophosphorylated Cdk2 Substrates in the Presence of Native Cysteine by Lee, Sarah E, Elphick, Lucy M, Kramer, Holger B, Jones, Alexandra M.E, Child, Emma S, Anderson, Alexandra A, Bonnac, Laurent, Suwaki, Natsuko, Kessler, Benedikt M, Gouverneur, Véronique, Mann, David J

“…The elucidation of signalling pathways relies heavily upon the identification of protein kinase substrates. Recent investigations have demonstrated the…”
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Quantitative Comparison of Wild-Type and Gatekeeper Mutant Cdk2 for Chemical Genetic Studies with ATP Analogues by Elphick, Lucy M, Lee, Sarah E, Child, Emma S, Prasad, Aarathi, Pignocchi, Cristina, Thibaudeau, Sébastien, Anderson, Alexandra A, Bonnac, Laurent, Gouverneur, Véronique, Mann, David J

“…Mutant kinase kinetics: Protein kinases with enlarged ATP binding sites are increasingly being used as tools to probe the functioning signal transduction…”
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Differential regulation of the cyclin-dependent kinase inhibitors p21Cip1 and p27Kip1 by phosphorylation directed by the cyclin encoded by Murine Herpesvirus 68 by Yarmishyn, Aliaksandr, Child, Emma S., Elphick, Lucy M., Mann, David J.

“…Members of the [gamma]2-herpesvirus family encode cyclin-like proteins that have the ability to deregulate mammalian cell cycle control. Here we report the key…”
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Live cell detection of caspase-3 activation by a Discosoma-red-fluorescent-protein-based fluorescence resonance energy transfer construct by Elphick, Lucy M., Meinander, Annika, Mikhailov, Andrey, Richard, Morgiane, Toms, Nick J., Eriksson, John E., Kass, George E.N.

“…A probe consisting of Discosoma red fluorescent protein (DsRed) and enhanced yellow fluorescent protein (EYFP) linked by a 19-amino-acid chain containing the…”
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Exploring the roles of protein kinases using chemical genetics by Elphick, Lucy M, Lee, Sarah E, Anderson, Alexandra A, Child, Emma S, Bonnac, Laurent, Gouverneur, Véronique, Mann, David J

“…The protein kinase superfamily is one of the most important families of enzymes in molecular biology. Protein kinases typically catalyze the transfer of the…”
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Opposing roles for caspase and calpain death proteases in l -glutamate-induced oxidative neurotoxicity by Hawat, Mohammad, Kaksonen, Elina, Elphick, Lucy M, Toms, Nick J, Eriksson, John E, Kass, George E.N

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Introducing Our Authors by Zhou, Zhe, Cironi, Pablo, Lin, Alison J, Derda, Ratmir, Elphick, Lucy M, Lee, Sarah E, Chen, Jinhua, Geske, Grant D, Zhang, Yan

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Development of autotaxin inhibitors: A series of tetrazole cinnamides by Thomson, Christopher G., Le Grand, Darren, Dowling, Mark, Beattie, David, Elphick, Lucy, Faller, Michael, Freeman, Mark, Hardaker, Elizabeth, Head, Victoria, Hemmig, Rene, Hill, Johan, Lister, Andrew, Pascoe, David, Rieffel, Sebastien, Shrestha, Binesh, Steward, Oliver, Zink, Florence

“…A series of inhibitors of Autotaxin (ATX) have been developed from a high throughput screening hit, 1a, which shows an alternative binding mode to known…”
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Development of autotaxin inhibitors: A series of zinc binding triazoles by Thomson, Christopher G., Le Grand, Darren, Dowling, Mark, Brocklehurst, Cara E., Chinn, Colin, Elphick, Lucy, Faller, Michael, Freeman, Mark, Furminger, Vikki, Gasser, Cornelia, Hamadi, Ahmed, Hardaker, Elizabeth, Head, Victoria, Hill, Johan C., Janus, Diana I., Pearce, David, Poulaud, Anne-Sophie, Stanley, Emily, Sviridenko, Lilya

“…[Display omitted] •PF-8380 has been used as a template to design a new series of ATX inhibitors.•Reduction of crystallinity was key to improving solubility of…”
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Differential regulation of the cyclin-dependent kinase inhibitors p21 super(Cip1) and p27 super(Kip1) by phosphorylation directed by the cyclin encoded by Murine Herpesvirus 68 by Yarmishyn, Aliaksandr, Child, Emma S, Elphick, Lucy M, Mann, David J

“…Members of the gamma 2-herpesvirus family encode cyclin-like proteins that have the ability to deregulate mammalian cell cycle control. Here we report the key…”
Get full text

Differential regulation of the cyclin-dependent kinase inhibitors p21 Cip1 and p27 Kip1 by phosphorylation directed by the cyclin encoded by Murine Herpesvirus 68 by Yarmishyn, Aliaksandr, Child, Emma S., Elphick, Lucy M., Mann, David J.

“…Members of the γ2-herpesvirus family encode cyclin-like proteins that have the ability to deregulate mammalian cell cycle control. Here we report the key…”
Get full text

Development of a Novel FRET Construct in the Investigation of Caspase Dependent and Caspase Independent Neurodegeneration by Elphick, Lucy M

“…Acute cerebral ischaemic injury results in increased neurotransmitter release which can result in cell death via receptor and non-receptor mediated mechanisms…”
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