Search Results - "Elmslie, R."

Checkpoint molecule expression by B and T cell lymphomas in dogs by Hartley, G., Elmslie, R., Dow, S., Guth, A.

“…Immunotherapies targeting checkpoint molecule programmed cell death 1 (PD‐1) protein were shown to be effective for treatment of non‐Hodgkin lymphoma in…”
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Metronomic Therapy with Cyclophosphamide and Piroxicam Effectively Delays Tumor Recurrence in Dogs with Incompletely Resected Soft Tissue Sarcomas by Elmslie, R.E., Glawe, P., Dow, S.W.

“…Background: Continuous administration of low doses of cyclophosphamide and standard doses of cyclooxygenase‐inhibiting drugs has been shown to suppress tumor…”
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c‐Kit Mutation and Localization Status as Response Predictors in Mast Cell Tumors in Dogs Treated with Prednisone and Toceranib or Vinblastine by Weishaar, K.M., Ehrhart, E.J., Avery, A.C., Charles, J.B., Elmslie, R.E., Vail, D.M., London, C.A., Clifford, C.A., Eickhoff, J.C., Thamm, D.H.

“…Background KIT inhibitors, such as toceranib (TOC), and vinblastine (VBL) have not been prospectively compared in the treatment of macroscopic mast cell tumors…”
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Flow Cytometric Characterization and Clinical Outcome of CD4+ T‐Cell Lymphoma in Dogs: 67 Cases by Avery, P.R, Burton, J, Bromberek, J.L, Seelig, D.M, Elmslie, R, Correa, S, Ehrhart, E.J, Morley, P.S, Avery, A.C

“…BACKGROUND: Canine T‐cell lymphoma (TCL) is conventionally considered an aggressive disease, but some forms are histologically and clinically indolent. CD4 TCL…”
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Changes in Regulatory T Cells in Dogs with Cancer and Associations with Tumor Type by O'Neill, K, Guth, A, Biller, B, Elmslie, R, Dow, S

“…Background: Regulatory T cells (Treg) have been shown to suppress antitumor immunity and often are increased in humans and rodents with cancer. However, Tregs…”
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Alternating Rabacfosadine/Doxorubicin: Efficacy and Tolerability in Naïve Canine Multicentric Lymphoma by Thamm, D.H., Vail, D.M., Post, G.S., Fan, T.M., Phillips, B.S., Axiak‐Bechtel, S., Elmslie, R.S., Klein, M.K., Ruslander, D.A.

“…Background Standard of care treatment for multicentric lymphoma in dogs remains doxorubicin (DOX)‐based combination chemotherapy, but owners may hesitate to…”
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Use of FoxP3 expression to identify regulatory T cells in healthy dogs and dogs with cancer by Biller, B.J., Elmslie, R.E., Burnett, R.C., Avery, A.C., Dow, S.W.

“…Regulatory T cells (Treg) are a distinct group of T lymphocytes with immunosuppressive properties that serve normally to prevent harmful autoimmune responses…”
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A Randomized Trial Investigating the Efficacy and Safety of Water Soluble Micellar Paclitaxel (Paccal Vet) for Treatment of Nonresectable Grade 2 or 3 Mast Cell Tumors in Dogs by Vail, D.M., von Euler, H., Rusk, A.W., Barber, L., Clifford, C., Elmslie, R., Fulton, L., Hirschberger, J., Klein, M., London, C., Martano, M., McNiel, E.A., Morris, J.S., Northrup, N., Phillips, B., Polton, G., Post, G., Rosenberg, M., Ruslander, D., Sahora, A., Siegel, S., Thamm, D., Westberg, S., Winter, J., Khanna, C.

“…Background Effective treatments for dogs with advanced stage mast cell tumors (MCT) remain a pressing need. A micellar formulation of paclitaxel (paclitaxel…”
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Liposomal clodronate treatment for tumour macrophage depletion in dogs with soft-tissue sarcoma by Guth, A. M., Hafeman, S. D., Elmslie, R. E., Dow, S. W.

“…Increased numbers of tumour‐associated macrophages correlate with rapid tumour growth and metastasis in tumours. Thus, macrophage depletion has potential as a…”
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Liposome-DNA complexes infused intravenously inhibit tumor angiogenesis and elicit antitumor activity in dogs with soft tissue sarcoma by Kamstock, D, Guth, A, Elmslie, R, Kurzman, I, Liggitt, D, Coro, L, Fairman, J, Dow, S

“…Intravenous gene delivery using liposome-DNA complexes (LDC) has previously been shown to elicit antitumor activity, but only in rodent tumor models…”
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Treatment of canine mast cell tumours with vinblastine, cyclophosphamide and prednisone: 35 cases (1997-2004) by Camps-Palau, M. A., Leibman, N. F., Elmslie, R., Lana, S. E., Plaza, S., McKnight, J. A., Risbon, R., Bergman, P. J.

“…The purpose of this retrospective study was to determine the efficacy and toxicity of a combined protocol of vinblastine, cyclophosphamide and prednisone (VCP)…”
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In vivo tumor transfection with superantigen plus cytokine genes induces tumor regression and prolongs survival in dogs with malignant melanoma by Dow, S W, Elmslie, R E, Willson, A P, Roche, L, Gorman, C, Potter, T A

“…In vivo transfection of established tumors with immunostimulatory genes can elicit antitumor immunity. Therefore, we evaluated the safety and efficacy of…”
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Intravenous cytokine gene delivery by lipid-DNA complexes controls the growth of established lung metastases by Dow, S W, Elmslie, R E, Fradkin, L G, Liggitt, D H, Heath, T D, Willson, A P, Potter, T A

“…Local expression of cytokine genes by ex vivo transfection or intratumoral gene delivery can control the growth of cutaneous tumors. However, control of tumor…”
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A phase I study using direct combination DNA injections for the immunotherapy of metastatic melanoma. University of Colorado Cancer Center Clinical Trial by Walsh, P, Gonzalez, R, Dow, S, Elmslie, R, Potter, T, Glode, L M, Baron, A E, Balmer, C, Easterday, K, Allen, J, Rosse, P

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Efficacy of mitoxantrone against various neoplasms in dogs by Ogilvie, G K, Obradovich, J E, Elmslie, R E, Vail, D M, Moore, A S, Straw, R C, Dickinson, K, Cooper, M F, Withrow, S J

“…One hundred twenty-six dogs with histologically confirmed, measurable malignant tumors were evaluated in a prospective study to determine the response to the…”
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Gastric surgery for morbid obesity. The Adelaide Study by Hall, J C, Watts, J M, O'Brien, P E, Dunstan, R E, Walsh, J F, Slavotinek, A H, Elmslie, R G

“…The efficacy of three gastric restriction operations were compared in a prospective randomized study of 310 morbidly obese subjects. The median patient age was…”
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Phase I study of liposome-DNA complexes encoding the interleukin-2 gene in dogs with osteosarcoma lung metastases by Dow, Steven, Elmslie, Robyn, Kurzman, Ilene, MacEwen, Gregory, Pericle, Federica, Liggitt, Denny

“…Systemic gene delivery using cationic liposome-DNA complexes (LDCs) has been shown to elicit potent antitumor activity in mice with tumor metastases to the…”
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Continuous low-dose oral chemotherapy for adjuvant therapy of splenic hemangiosarcoma in dogs by Lana, S, U'ren, L, Plaza, S, Elmslie, R, Gustafson, D, Morley, P, Dow, S

“…Background: Hemangiosarcoma (HSA) is a highly metastatic and often rapidly fatal tumor in dogs. At present, conventional adjuvant chemotherapy provides only a…”
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Evaluation of a xenogeneic VEGF vaccine in dogs with soft tissue sarcoma by Kamstock, Debra, Elmslie, Robyn, Thamm, Douglas, Dow, Steven

“…Active immunization against pro-angiogenic growth factors or their receptors is an emerging strategy for controlling tumor growth and angiogenesis. Previous…”
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Flow Cytometric Characterization and Clinical Outcome of CD 4+ T‐Cell Lymphoma in Dogs: 67 Cases by Avery, P.R., Burton, J., Bromberek, J.L., Seelig, D.M., Elmslie, R., Correa, S., Ehrhart, E.J., Morley, P.S., Avery, A.C.

“…Background Canine T‐cell lymphoma ( TCL ) is conventionally considered an aggressive disease, but some forms are histologically and clinically indolent. CD 4…”
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