Angiotensin converting enzyme gene (I/D) polymorphism and susceptibility of childhood asthma and coincident atopic diseases

ACE level has been linked to bronchial hyper-reactivity and airway inflammation. ACE gene (I/D) polymorphism has been associated with asthma and atopy although the findings between cohorts have not been uniform. We conducted this cross-sectional study to evaluate the possible role of ACE gene I/D po...

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Bibliographic Details
Published in:	Meta Gene Vol. 10; pp. 18 - 22
Main Authors:	Elmoneim, Mahmoud Tarek Abd, Fouda, Eman Mahmoud, Nabih, Enas Samir, Radwan, Amira Adel Mohamed
Format:	Journal Article
Language:	English
Published:	Elsevier B.V 01-12-2016
Subjects:	ACE Asthma Atopy IgE Polymorphism ACE IgE Asthma Atopy Polymorphism
Online Access:	Get full text
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Summary:	ACE level has been linked to bronchial hyper-reactivity and airway inflammation. ACE gene (I/D) polymorphism has been associated with asthma and atopy although the findings between cohorts have not been uniform. We conducted this cross-sectional study to evaluate the possible role of ACE gene I/D polymorphism in the association between bronchial asthma and other atopic diseases in asthmatic children and adolescents. Genotyping of ACE gene (I/D) polymorphism was done by RFLP-PCR in 200 asthmatic children and adolescents. Serum levels of total IgE were measured by ELISA. Skin prick test was performed on all participants. We found a high frequency of DD genotype compared to other genotypes. We also noticed that children carrying ACE DD genotype had a higher incidence of asthma and a higher coincidence of allergic rhinitis. In conclusion, our findings represent an evidence for the role of ACE gene I/D polymorphism in childhood asthma and its coincidence with allergic rhinitis.
ISSN:	2214-5400 2214-5400
DOI:	10.1016/j.mgene.2016.09.009