Search Results - "Elmer, Greg I"

Habenula-Induced Inhibition of Midbrain Dopamine Neurons Is Diminished by Lesions of the Rostromedial Tegmental Nucleus by Brown, P Leon, Palacorolla, Heather, Brady, Dana, Riegger, Katelyn, Elmer, Greg I, Shepard, Paul D

“…Neurons in the lateral habenula (LHb) are transiently activated by aversive events and have been implicated in associative learning. Functional changes…”
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Fluctuations in Endogenous Kynurenic Acid Control Hippocampal Glutamate and Memory by POCIVAVSEK, Ana, WU, Hui-Qiu, POTTER, Michelle C, ELMER, Greg I, PELLICCIARI, Roberto, SCHWARCZ, Robert

“…Kynurenic acid (KYNA), an astrocyte-derived metabolite, antagonizes the α7 nicotinic acetylcholine receptor (α7nAChR) and, possibly, the glycine co-agonist…”
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Reduction of Endogenous Kynurenic Acid Formation Enhances Extracellular Glutamate, Hippocampal Plasticity, and Cognitive Behavior by POTTER, Michelle C, ELMER, Greg I, BERGERON, Richard, ALBUQUERQUE, Edson X, GUIDETTI, Paolo, WU, Hui-Qiu, SCHWARCZ, Robert

“…At endogenous brain concentrations, the astrocyte-derived metabolite kynurenic acid (KYNA) antagonizes the alpha 7 nicotinic acetylcholine receptor and,…”
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Pre- and postnatal exposure to kynurenine causes cognitive deficits in adulthood by Pocivavsek, Ana, Wu, Hui-Qiu, Elmer, Greg I., Bruno, John P., Schwarcz, Robert

“…Levels of kynurenic acid (KYNA), an endogenous product of tryptophan degradation, are elevated in the brain and cerebrospinal fluid of individuals with…”
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Anti-relapse neurons in the infralimbic cortex of rats drive relapse-suppression by drug omission cues by Laque, Amanda, L. De Ness, Genna, Wagner, Grant E., Nedelescu, Hermina, Carroll, Ayla, Watry, Debbie, M. Kerr, Tony, Koya, Eisuke, Hope, Bruce T., Weiss, Friedbert, Elmer, Greg I., Suto, Nobuyoshi

“…Drug addiction is a chronic relapsing disorder of compulsive drug use. Studies of the neurobehavioral factors that promote drug relapse have yet to produce an…”
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Engaging Research Domain Criteria (RDoC): Neurocircuitry in Search of Meaning by Elmer, Greg I, Brown, P Leon, Shepard, Paul D

“…The Research Domain Criteria (RDoC) initiative was implemented to reorient the approach to mental health research from one focused on Diagnostic and…”
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Hyperoxic reperfusion after global cerebral ischemia promotes inflammation and long-term hippocampal neuronal death by Hazelton, Julie L, Balan, Irina, Elmer, Greg I, Kristian, Tibor, Rosenthal, Robert E, Krause, Gary, Sanderson, Thomas H, Fiskum, Gary

“…In this study we tested the hypothesis that long-term neuropathological outcome is worsened by hyperoxic compared to normoxic reperfusion in a rat global…”
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The habenula governs the attribution of incentive salience to reward predictive cues by Danna, Carey L, Shepard, Paul D, Elmer, Greg I

“…The attribution of incentive salience to reward associated cues is critical for motivation and the pursuit of rewards. Disruptions in the integrity of the…”
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Inhibition of kynurenine aminotransferase II attenuates hippocampus‐dependent memory deficit in adult rats treated prenatally with kynurenine by Pocivavsek, Ana, Elmer, Greg I., Schwarcz, Robert

“…A combination of genetic and environmental factors contributes to schizophrenia (SZ), a catastrophic psychiatric disorder with a hypothesized…”
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MicroRNAs Are Involved in the Development of Morphine-Induced Analgesic Tolerance and Regulate Functionally Relevant Changes in Serpini1 by Tapocik, Jenica D, Ceniccola, Kristin, Mayo, Cheryl L, Schwandt, Melanie L, Solomon, Matthew, Wang, Bi-Dar, Luu, Truong V, Olender, Jacqueline, Harrigan, Thomas, Maynard, Thomas M, Elmer, Greg I, Lee, Norman H

“…Long-term opioid treatment results in reduced therapeutic efficacy and in turn leads to an increase in the dose required to produce equivalent pain relief and…”
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Genotype-Environment Interactions in Mouse Behavior: A Way out of the Problem by Kafkafi, Neri, Benjamini, Yoav, Sakov, Anat, Elmer, Greg I., Golani, Ilan, Teitelbaum, Philip

“…In behavior genetics, behaviroal patterns of mouse genotypes, such as inbred strains, crosses, and knockouts, are characterized and compared to associate them…”
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NMDAR inhibition-independent antidepressant actions of ketamine metabolites by Zanos, Panos, Moaddel, Ruin, Morris, Patrick J., Georgiou, Polymnia, Fischell, Jonathan, Elmer, Greg I., Alkondon, Manickavasagom, Yuan, Peixiong, Pribut, Heather J., Singh, Nagendra S., Dossou, Katina S. S., Fang, Yuhong, Huang, Xi-Ping, Mayo, Cheryl L., Wainer, Irving W., Albuquerque, Edson X., Thompson, Scott M., Thomas, Craig J., Zarate Jr, Carlos A., Gould, Todd D.

“…Major depressive disorder affects around 16 per cent of the world population at some point in their lives. Despite the availability of numerous…”
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Heritability of nociception I: responses of 11 inbred mouse strains on 12 measures of nociception by Mogil, J S, Wilson, S G, Bon, K, Lee, S E, Chung, K, Raber, P, Pieper, J O, Hain, H S, Belknap, J K, Hubert, L, Elmer, G I, Chung, J M, Devor, M

“…It is generally acknowledged that humans display highly variable sensitivity to pain, including variable responses to identical injuries or pathologies. The…”
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Combined Application of Behavior Genetics and Microarray Analysis to Identify Regional Expression Themes and Gene-Behavior Associations by Letwin, Noah E, Kafkafi, Neri, Benjamini, Yoav, Mayo, Cheryl, Frank, Bryan C, Luu, Troung, Lee, Norman H, Elmer, Greg I

“…In this report we link candidate genes to complex behavioral phenotypes by using a behavior genetics approach. Gene expression signatures were generated for…”
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Altered spatial learning, cortical plasticity and hippocampal anatomy in a neurodevelopmental model of schizophrenia-related endophenotypes by Brown, P. Leon, Shepard, Paul D., Elmer, Greg I., Stockman, Sara, McFarland, Rebecca, Mayo, Cheryl L., Cadet, Jean Lud, Krasnova, Irina N., Greenwald, Martin, Schoonover, Carrie, Vogel, Michael W.

“…Adult rats exposed to the DNA‐methylating agent methylazoxymethanol on embryonic day 17 show a pattern of neurobiological deficits that model some of the…”
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Substantia Nigra Dopamine Neuronal Responses to Habenular Stimulation and Foot Shock Are Altered by Lesions of the Rostromedial Tegmental Nucleus by Brown, P. Leon, Palacorolla, Heather, Cobb-Lewis, Dana E., Jhou, Thomas C., McMahon, Pat, Bell, Dana, Elmer, Greg I., Shepard, Paul D.

“…•RMTg lesions reduce LHb induced inhibition of DA firing.•RMTg lesions reduce foot shock induced inhibition of DA firing.•Lower prevalence of neurons with…”
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Ketamine metabolite (2R,6R)-hydroxynorketamine reverses behavioral despair produced by adolescent trauma by Elmer, Greg I., Tapocik, Jenica D., Mayo, Cheryl L., Zanos, Panos, Gould, Todd D.

“…Early life trauma dramatically increases the risk of developing major depressive disorder (MDD), and is associated with a markedly decreased adult treatment…”
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Heritability of nociception II. 'Types' of nociception revealed by genetic correlation analysis by Mogil, J S, Wilson, S G, Bon, K, Lee, S E, Chung, K, Raber, P, Pieper, J O, Hain, H S, Belknap, J K, Hubert, L, Elmer, G I, Chung, J M, Devor, M

“…Clinical pain syndromes, and experimental assays of nociception, are differentially affected by manipulations such as drug administration and exposure to…”
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White matter and latency of visual evoked potentials during maturation: A miniature pig model of adolescent development by Kochunov, Peter, Hong, L. Elliot, Summerfelt, Ann, Gao, Si, Brown, P. Leon, Terzi, Matthew, Acheson, Ashley, Woldorff, Marty G., Fieremans, Els, Abdollahzadeh, Ali, Sathyasaikumar, Korrapati V., Clark, Sarah M., Schwarcz, Robert, Shepard, Paul D., Elmer, Greg I.

“…Continuous myelination of cerebral white matter (WM) during adolescence overlaps with the formation of higher cognitive skills and the onset of many…”
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Continuous kynurenine administration during the prenatal period, but not during adolescence, causes learning and memory deficits in adult rats by Pocivavsek, Ana, Thomas, Marian A. R., Elmer, Greg I., Bruno, John P., Schwarcz, Robert

“…Rationale Cognitive dysfunctions, including deficits in hippocampus-mediated learning and memory, are core features of the psychopathology of schizophrenia…”
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