Search Results - "Elman, Jeremy A"

Influence of young adult cognitive ability and additional education on later-life cognition by Kremen, William S., Beck, Asad, Elman, Jeremy A., Gustavson, Daniel E., Reynolds, Chandra A., Tu, Xin M., Sanderson-Cimino, Mark E., Panizzon, Matthew S., Vuoksimaa, Eero, Toomey, Rosemary, Fennema-Notestine, Christine, Hagler, Donald J., Fang, Bin, Dale, Anders M., Lyons, Michael J., Franz, Carol E.

“…How and when education improves cognitive capacity is an issue of profound societal importance. Education and later-life education-related factors, such as…”
Get full text

Effects of Beta-Amyloid on Resting State Functional Connectivity Within and Between Networks Reflect Known Patterns of Regional Vulnerability by Elman, Jeremy A, Madison, Cindee M, Baker, Suzanne L, Vogel, Jacob W, Marks, Shawn M, Crowley, Sam, O'Neil, James P, Jagust, William J

“…Beta-amyloid (Aβ) deposition is one of the hallmarks of Alzheimer's disease (AD). However, it is also present in some cognitively normal elderly adults and may…”
Get full text

A Traitlike Dimension of Subjective Memory Concern Over 30 Years Among Adult Male Twins by Bell, Tyler R, Beck, Asad, Gillespie, Nathan A, Reynolds, Chandra A, Elman, Jeremy A, Williams, McKenna E, Gustavson, Daniel E, Lyons, Michael J, Neale, Michael C, Kremen, William S, Franz, Carol E

“…Subjective memory concern has long been considered a state-related indicator of impending cognitive decline or dementia. The possibility that subjective memory…”
Get more information

Issues and recommendations for the residual approach to quantifying cognitive resilience and reserve by Elman, Jeremy A, Vogel, Jacob W, Bocancea, Diana I, Ossenkoppele, Rik, van Loenhoud, Anna C, Tu, Xin M, Kremen, William S

“…Cognitive reserve and resilience are terms used to explain interindividual variability in maintenance of cognitive health in response to adverse factors, such…”
Get full text

Cognitive Reserve and Related Constructs: A Unified Framework Across Cognitive and Brain Dimensions of Aging by Kremen, William S, Elman, Jeremy A, Panizzon, Matthew S, Eglit, Graham M L, Sanderson-Cimino, Mark, Williams, McKenna E, Lyons, Michael J, Franz, Carol E

“…Cognitive reserve and related constructs are valuable for aging-related research, but consistency and clarification of terms is needed as there is still no…”
Get full text

Association of neurofilament light chain with renal function: mechanisms and clinical implications by Tang, Rongxiang, Panizzon, Matthew S, Elman, Jeremy A, Gillespie, Nathan A, Hauger, Richard L, Rissman, Robert A, Lyons, Michael J, Neale, Michael C, Reynolds, Chandra A, Franz, Carol E, Kremen, William S

“…Blood-based neurofilament light chain (NfL) is a promising biomarker of neurodegeneration across multiple neurodegenerative diseases. However, blood-based NfL…”
Get full text

Underdiagnosis of mild cognitive impairment: A consequence of ignoring practice effects by Elman, Jeremy A., Jak, Amy J., Panizzon, Matthew S., Tu, Xin M., Chen, Tian, Reynolds, Chandra A., Gustavson, Daniel E., Franz, Carol E., Hatton, Sean N., Jacobson, Kristen C., Toomey, Rosemary, McKenzie, Ruth, Xian, Hong, Lyons, Michael J., Kremen, William S.

“…Longitudinal testing is necessary to accurately measure cognitive change. However, repeated testing is susceptible to practice effects, which may obscure true…”
Get full text

Associations of plasma neurofilament light chain with cognition and neuroimaging measures in community-dwelling early old age men by Tang, Rongxiang, Buchholz, Erik, Dale, Anders M, Rissman, Robert A, Fennema-Notestine, Christine, Gillespie, Nathan A, Hagler, Jr, Donald J, Lyons, Michael J, Neale, Michael C, Panizzon, Matthew S, Puckett, Olivia K, Reynolds, Chandra A, Franz, Carol E, Kremen, William S, Elman, Jeremy A

“…Plasma neurofilament light chain (NfL) is a promising biomarker of neurodegeneration with potential clinical utility in monitoring the progression of…”
Get full text

Associations among executive function Abilities, free Water, and white matter microstructure in early old age by Gustavson, Daniel E., Archer, Derek B., Elman, Jeremy A., Puckett, Olivia K., Fennema-Notestine, Christine, Panizzon, Matthew S., Shashikumar, Niranjana, Hohman, Timothy J., Jefferson, Angela L., Eyler, Lisa T., McEvoy, Linda K., Lyons, Michael J., Franz, Carol E., Kremen, William S.

“…•Executive function is primarily associated with free water in early old age.•Associations were driven by individuals with mild cognitive impairment.•No…”
Get full text

Metabolic Profiling of Cognitive Aging in Midlife by Huo, Zhiguang, Rana, Brinda K, Elman, Jeremy A, Dong, Ruocheng, Engelman, Corinne D, Johnson, Sterling C, Lyons, Michael J, Franz, Carol E, Kremen, William S, Zhao, Jinying

“…Alzheimer's dementia (AD) begins many years before its clinical symptoms. Metabolic dysfunction represents a core feature of AD and cognitive impairment, but…”
Get full text

Practice Effects in Mild Cognitive Impairment Increase Reversion Rates and Delay Detection of New Impairments by Sanderson-Cimino, Mark, Elman, Jeremy A, Tu, Xin M, Gross, Alden L, Panizzon, Matthew S, Gustavson, Daniel E, Bondi, Mark W, Edmonds, Emily C, Eppig, Joel S, Franz, Carol E, Jak, Amy J, Lyons, Michael J, Thomas, Kelsey R, Williams, McKenna E, Kremen, William S

“…Cognitive practice effects (PEs) can delay detection of progression from cognitively unimpaired to mild cognitive impairment (MCI). They also reduce diagnostic…”
Get full text

The Impact of Genes and Environment on Brain Ageing in Males Aged 51 to 72 Years by Gillespie, Nathan A, Hatton, Sean N, Hagler, Jr, Donald J, Dale, Anders M, Elman, Jeremy A, McEvoy, Linda K, Eyler, Lisa T, Fennema-Notestine, Christine, Logue, Mark W, McKenzie, Ruth E, Puckett, Olivia K, Tu, Xin M, Whitsel, Nathan, Xian, Hong, Reynolds, Chandra A, Panizzon, Matthew S, Lyons, Michael J, Neale, Michael C, Kremen, William S, Franz, Carol

“…Magnetic resonance imaging data are being used in statistical models to predicted brain ageing (PBA) and as biomarkers for neurodegenerative diseases such as…”
Get full text

Alcohol intake and brain white matter in middle aged men: Microscopic and macroscopic differences by McEvoy, Linda K., Fennema-Notestine, Christine, Elman, Jeremy A., Eyler, Lisa T., Franz, Carol E., Hagler, Donald J., Hatton, Sean N., Lyons, Michael J., Panizzon, Matthew S., Dale, Anders M., Kremen, William S.

“…Heavy alcohol consumption is associated with deleterious changes in the brain but associations of moderate alcohol intake are not well understood. We examined…”
Get full text

Association Between Traumatic Brain Injury and Cognitive Decline Among Middle-to-Older Aged Men in the Vietnam Era Twin Study of Aging by Posis, Alexander Ivan B, Alcaraz, John E, Parada, Jr, Humberto, Shadyab, Aladdin H, Elman, Jeremy A, Panizzon, Matthew S, Reynolds, Chandra A, Franz, Carol E, Kremen, William S, McEvoy, Linda K

“…Traumatic brain injury (TBI) is associated with increased risk of dementia. However, whether TBI is associated with greater cognitive decline over time in…”
Get full text

Cognitive practice effects delay diagnosis of MCI: Implications for clinical trials by Sanderson‐Cimino, Mark, Elman, Jeremy A., Tu, Xin M., Gross, Alden L., Panizzon, Matthew S., Gustavson, Daniel E., Bondi, Mark W., Edmonds, Emily C., Eglit, Graham M.L., Eppig, Joel S., Franz, Carol E., Jak, Amy J., Lyons, Michael J., Thomas, Kelsey R., Williams, McKenna E., Kremen, William S.

“…Introduction Practice effects (PEs) on cognitive tests obscure decline, thereby delaying detection of mild cognitive impairment (MCI). Importantly, PEs may be…”
Get full text

Extensive memory testing improves prediction of progression to MCI in late middle age by Gustavson, Daniel E., Elman, Jeremy A., Sanderson‐Cimino, Mark, Franz, Carol E., Panizzon, Matthew S., Jak, Amy J., Reynolds, Chandra A., Neale, Michael C., Lyons, Michael J., Kremen, William S.

“…Introduction Predicting risk for Alzheimer's disease when most people are likely still biomarker negative would aid earlier identification. We hypothesized…”
Get full text

Pathway-Specific Polygenic Risk Scores Correlate with Clinical Status and Alzheimer's Disease-Related Biomarkers by Schork, Nicholas J, Elman, Jeremy A

“…APOE is the largest genetic risk factor for Alzheimer's disease (AD), but there is a substantial polygenic component. Polygenic risk scores (PRS) can summarize…”
Get more information

Exploring the Genetic Heterogeneity of Alzheimer's Disease: Evidence for Genetic Subtypes by Elman, Jeremy A, Schork, Nicholas J, Rangan, Aaditya V

“…Alzheimer's disease (AD) exhibits considerable phenotypic heterogeneity, suggesting the potential existence of subtypes. AD is under substantial genetic…”
Get more information

Genetic Underpinnings of Increased BMI and Its Association With Late Midlife Cognitive Abilities by Xian, Hong, Boutwell, Brian, Reynolds, Chandra A., Lew, Daphne, Logue, Mark, Gustavson, Daniel E., Kavish, Nicholas, Panizzon, Matthew S., Tu, Xin, Toomey, Rosemary, Puckett, Olivia K., Elman, Jeremy A., Jacobson, Kristen C., Lyons, Michael J., Kremen, William S., Franz, Carol E.

“…Objectives: First, we test for differences in various cognitive abilities across trajectories of body mass index (BMI) over the later life course. Second, we…”
Get full text

Use of an Alzheimer’s disease polygenic risk score to identify mild cognitive impairment in adults in their 50s by Logue, Mark W., Panizzon, Matthew S., Elman, Jeremy A., Gillespie, Nathan A., Hatton, Sean N., Gustavson, Daniel E., Andreassen, Ole A., Dale, Anders M., Franz, Carol E., Lyons, Michael J., Neale, Michael C., Reynolds, Chandra A., Tu, Xin, Kremen, William S.

“…Early identification of younger, non-demented adults at elevated risk for Alzheimer’s disease (AD) is crucial because the pathological process begins decades…”
Get full text