Search Results - "Elm, J."

Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA by Johnston, S. Claiborne, Easton, J. Donald, Farrant, Mary, Barsan, William, Conwit, Robin A, Elm, Jordan J, Kim, Anthony S, Lindblad, Anne S, Palesch, Yuko Y

“…In this international, randomized trial, patients with minor stroke or TIA who received clopidogrel plus aspirin had a lower risk of major ischemic events but…”
Get full text

Methane sulfonic acid-enhanced formation of molecular clusters of sulfuric acid and dimethyl amine by Bork, N, Elm, J, Olenius, T, Vehkamäki, H

“…Over oceans and in coastal regions, methane sulfonic acid (MSA) is present in substantial concentrations in aerosols and in the gas phase. We present an…”
Get full text

Safety and efficacy of intravenous glyburide on brain swelling after large hemispheric infarction (GAMES-RP): a randomised, double-blind, placebo-controlled phase 2 trial by Sheth, Kevin N, Dr, Elm, Jordan J, PhD, Molyneaux, Bradley J, MD, Hinson, Holly, MD, Beslow, Lauren A, MD, Sze, Gordon K, MD, Ostwaldt, Ann-Christin, PhD, del Zoppo, Gregory J, Prof, Simard, J Marc, Prof, Jacobson, Sven, BSE, Kimberly, W Taylor, Dr

“…Summary Background Preclinical models of stroke have shown that intravenous glyburide reduces brain swelling and improves survival. We assessed whether…”
Get full text

Mapping acute lesion locations to physiological swallow impairments after stroke by Wilmskoetter, Janina, Bonilha, Leonardo, Martin-Harris, Bonnie, Elm, Jordan J, Horn, Janet, Bonilha, Heather S

“…Dysphagia is a common deficit after a stroke, and it is frequently associated with pneumonia, malnutrition, dehydration, and poor quality of life. It is not…”
Get full text

The impact of depressive symptoms in early Parkinson disease by RAVINA, B, CAMICIOLI, R, COMO, P. G, MARSH, L, JANKOVIC, J, WEINTRAUB, D, ELM, J

“…Depressive disorders may affect up to 50% of patients with Parkinson disease (PD) and are associated with increased disability and reduced quality of life. No…”
Get full text

Adopting a Patient-Centered Approach to Primary Outcome Analysis of Acute Stroke Trials Using a Utility-Weighted Modified Rankin Scale by Chaisinanunkul, Napasri, Adeoye, Opeolu, Lewis, Roger J, Grotta, James C, Broderick, Joseph, Jovin, Tudor G, Nogueira, Raul G, Elm, Jordan J, Graves, Todd, Berry, Scott, Lees, Kennedy R, Barreto, Andrew D, Saver, Jeffrey L, Furlan, Anthony, Baxter, Blaise, Lutsep, Helmi L, Ribo, Marc, Jansen, Olav, Gupta, Rishi, Pereira, Vitor Mendes

“…BACKGROUND AND PURPOSE—Although the modified Rankin Scale (mRS) is the most commonly used primary end point in acute stroke trials, its power is limited when…”
Get full text

Effect of IV glyburide on adjudicated edema endpoints in the GAMES-RP Trial by Kimberly, W Taylor, Bevers, Matthew B, von Kummer, Rüdiger, Demchuk, Andrew M, Romero, Javier M, Elm, Jordan J, Hinson, Holly E, Molyneaux, Bradley J, Simard, J Marc, Sheth, Kevin N

“…OBJECTIVEIn this secondary analysis of the Glyburide Advantage in Malignant Edema and Stroke (GAMES-RP) Trial, we report the effect of IV glyburide on…”
Get full text

Sex Differences in Clinical Features of Early, Treated Parkinson's Disease by Augustine, Erika F, Pérez, Adriana, Dhall, Rohit, Umeh, Chizoba C, Videnovic, Aleksandar, Cambi, Franca, Wills, Anne-Marie A, Elm, Jordan J, Zweig, Richard M, Shulman, Lisa M, Nance, Martha A, Bainbridge, Jacquelyn, Suchowersky, Oksana

“…To improve our understanding of sex differences in the clinical characteristics of Parkinson's Disease, we sought to examine differences in the clinical…”
Get full text

Characterizing patient compliance over six months in remote digital trials of Parkinson's and Huntington disease by Cohen, Shani, Waks, Zeev, Elm, Jordan J, Gordon, Mark Forrest, Grachev, Igor D, Navon-Perry, Leehee, Fine, Shai, Grossman, Iris, Papapetropoulos, Spyros, Savola, Juha-Matti

“…A growing number of clinical trials use various sensors and smartphone applications to collect data outside of the clinic or hospital, raising the question to…”
Get full text

Newly Diagnosed Atrial Fibrillation After Transient Ischemic Attack Versus Minor Ischemic Stroke in the POINT Trial by Kamel, Hooman, Farrant, Mary, Easton, J Donald, Sposato, Luciano A, Elm, Jordan J, Underwood, Ellen, Johnston, S Claiborne

“…Background Atrial fibrillation/flutter (AF) after transient ischemic attack (TIA) has not been well studied. We compared the likelihood of new AF diagnosis…”
Get full text

A feasibility study of objective outcome measures used in clinical trials of freezing of gait by Revuelta, Gonzalo J, Embry, Aaron, Elm, Jordan J, Jenkins, Shonna, Lee, Philip, Kautz, Steve

“…Freezing of gait (FOG) is notoriously difficult to quantify, which has led to the use of multiple markers as outcomes for clinical trials. The instrumented…”
Get full text

Framework for advancing rigorous research by Koroshetz, Walter J, Behrman, Shannon, Brame, Cynthia J, Branchaw, Janet L, Brown, Emery N, Clark, Erin A, Dockterman, David, Elm, Jordan J, Gay, Pamela L, Green, Katelyn M, Hsi, Sherry, Kaplitt, Michael G, Kolber, Benedict J, Kolodkin, Alex L, Lipscombe, Diane, MacLeod, Malcolm R, McKinney, Caleb C, Munafò, Marcus R, Oakley, Barbara, Olimpo, Jeffrey T, Percie du Sert, Nathalie, Raman, Indira M, Riley, Ceri, Shelton, Amy L, Uzzo, Stephen Miles, Crawford, Devon C, Silberberg, Shai D

“…There is a pressing need to increase the rigor of research in the life and biomedical sciences. To address this issue, we propose that communities of 'rigor…”
Get full text

Fall frequency and risk assessment in early Parkinson's disease by Voss, T.S, Elm, J.J, Wielinski, C.L, Aminoff, M.J, Bandyopadhyay, D, Chou, K.L, Sudarsky, L.R, Tilley, B.C

“…Abstract Background We sought to define the frequency of falls in early PD and assess potential risk factors for falls in this population. Methods We analyzed…”
Get full text

A pharmacokinetic simulation study to assess the performance of a sparse blood sampling approach to quantify early drug exposure by Sathe, Abhishek G., Brundage, Richard C., Ivaturi, Vijay, Cloyd, James C., Chamberlain, James M., Elm, Jordan J., Silbergleit, Robert, Kapur, Jaideep, Coles, Lisa D.

“…Estimating early exposure of drugs used for the treatment of emergent conditions is challenging because blood sampling to measure concentrations is difficult…”
Get full text

Pioglitazone in early Parkinson's disease: a phase 2, multicentre, double-blind, randomised trial by Anon

“…Summary Background A systematic assessment of potential disease-modifying compounds for Parkinson's disease concluded that pioglitazone could hold promise for…”
Get full text

Optimizing the ongoing search for new treatments for parkinson disease : Using futility designs by TILLEY, B. C, PALESCH, Y. Y, KIEBURTZ, K, RAVINA, B, HUANG, P, ELM, J. J, SHANNON, K, WOOTEN, G. F, TANNER, C. M, GOETZ, G. C

“…Many agents are being considered for treatment of Parkinson disease (PD). Given the large number of agents and the limited resources to evaluate new agents, it…”
Get full text

Locked nucleic acid (LNA) mediated improvements in siRNA stability and functionality by Elmén, Joacim, Thonberg, Håkan, Ljungberg, Karl, Frieden, Miriam, Westergaard, Majken, Xu, Yunhe, Wahren, Britta, Liang, Zicai, Ørum, Henrik, Koch, Troels, Wahlestedt, Claes

“…Therapeutic application of the recently discovered small interfering RNA (siRNA) gene silencing phenomenon will be dependent on improvements in molecule…”
Get full text

Robustness of reliable change indices to variability in Parkinson's disease with mild cognitive impairment by Turner, T. H., Renfroe, J. B., Elm, J., Duppstadt-Delambo, A., Hinson, V. K.

“…Ability to identify change is crucial for measuring response to interventions and tracking disease progression. Beyond psychometrics, investigations of…”
Get full text

Validating Imaging Biomarkers of Cerebral Edema in Patients With Severe Ischemic Stroke by Yoo, Albert J., MD, Sheth, Kevin N., MD, Kimberly, W. Taylor, MD, PhD, Chaudhry, Zeshan A., MD, Elm, Jordan J., PhD, Jacobson, Sven, BSc, Davis, Stephen M., MD, Donnan, Geoffrey A., MD, Albers, Gregory W., MD, Stern, Barney J., MD, González, R. Gilberto, MD, PhD

“…Background There is no validated neuroimaging marker for quantifying brain edema. We sought to test whether magnetic resonance imaging (MRI)–based metrics…”
Get full text

Levetiracetam no better than phenytoin in children with convulsive status epilepticus by Silbergleit, Robert, Elm, Jordan J

“…Guidelines for benzodiazepine dosing are based on high-quality data from randomised controlled trials.1–3 Status epilepticus, treated according to guidelines,…”
Get full text