Search Results - "Elloso, M Merle"

CD4+ Lymphoid Tissue-Inducer Cells Promote Innate Immunity in the Gut by Sonnenberg, Gregory F., Monticelli, Laurel A., Elloso, M. Merle, Fouser, Lynette A., Artis, David

“…Fetal CD4+ lymphoid tissue inducer (LTi) cells play a critical role in the development of lymphoid tissues. Recent studies identified that LTi cells persist in…”
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Targeting the Th17 pathway in psoriasis by Elloso, M Merle, Gomez-Angelats, Mireia, Fourie, Anne M

“…Review of preclinical and clinical evidence implicating Th17 cells in psoriasis, and the therapeutic approaches to target this pathway. In recent years, the…”
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The Cytokines Interleukin 27 and Interferon-γ Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology by Hall, Aisling O’Hara, Beiting, Daniel P., Tato, Cristina, John, Beena, Oldenhove, Guillaume, Lombana, Claudia Gonzalez, Pritchard, Gretchen Harms, Silver, Jonathan S., Bouladoux, Nicolas, Stumhofer, Jason S., Harris, Tajie H., Grainger, John, Wojno, Elia D. Tait, Wagage, Sagie, Roos, David S., Scott, Philip, Turka, Laurence A., Cherry, Sara, Reiner, Steven L., Cua, Daniel, Belkaid, Yasmine, Elloso, M. Merle, Hunter, Christopher A.

“…Interferon-γ (IFN-γ) promotes a population of T-bet+ CXCR3+ regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies…”
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Molecular Mechanisms of Airway Hyperresponsiveness in a Murine Model of Steroid-Resistant Airway Inflammation by Manni, Michelle L, Mandalapu, Sivanarayana, McHugh, Kevin J, Elloso, M Merle, Dudas, Paul L, Alcorn, John F

“…IL-13 and IL-17A, produced mainly by Th2 and Th17 cells, respectively, have an influential role in asthma pathogenesis. We examined the role of IL-13 and…”
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Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model by Nakajima, Kimiko, Kanda, Takashi, Takaishi, Mikiro, Shiga, Takeo, Miyoshi, Ken, Nakajima, Hideki, Kamijima, Reiko, Tarutani, Masahito, Benson, Jacqueline M, Elloso, M Merle, Gutshall, Lester L, Naso, Michael F, Iwakura, Yoichiro, DiGiovanni, John, Sano, Shigetoshi

“…Psoriasis is an inflammatory disease with dynamic interactions between the immune system and the skin. The IL-23/Th17 axis plays an important role in the…”
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A role for IL-27p28 as an antagonist of gp130-mediated signaling by Hunter, Christopher A, Stumhofer, Jason S, Tait, Elia D, III, William J Quinn, Hosken, Nancy, Spudy, Björn, Goenka, Radhika, Fielding, Ceri A, O'Hara, Aisling C, Chen, Yi, Jones, Michael L, Saris, Christiaan J M, Rose-John, Stefan, Cua, Daniel J, Jones, Simon A, Elloso, Merle M, Grötzinger, Joachim, Cancro, Michael P, Levin, Steven D

“…The heterodimeric cytokine IL-27 consists of the subunits p28 and EBI3. Hunter and colleagues demonstrate that p28 acting alone can inhibit the signaling of…”
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IL-23 past, present, and future: a roadmap to advancing IL-23 science and therapy by Krueger, James G, Eyerich, Kilian, Kuchroo, Vijay K, Ritchlin, Christopher T, Abreu, Maria T, Elloso, M Merle, Fourie, Anne, Fakharzadeh, Steven, Sherlock, Jonathan P, Yang, Ya-Wen, Cua, Daniel J, McInnes, Iain B

“…Interleukin (IL)-23, an IL-12 cytokine family member, is a hierarchically dominant regulatory cytokine in a cluster of immune-mediated inflammatory diseases…”
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IL-27 Limits Type 2 Immunopathology Following Parainfluenza Virus Infection by Muallem, Gaia, Wagage, Sagie, Sun, Yan, DeLong, Jonathan H, Valenzuela, Alex, Christian, David A, Harms Pritchard, Gretchen, Fang, Qun, Buza, Elizabeth L, Jain, Deepika, Elloso, M Merle, López, Carolina B, Hunter, Christopher A

“…Respiratory paramyxoviruses are important causes of morbidity and mortality, particularly of infants and the elderly. In humans, a T helper (Th)2-biased immune…”
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Guselkumab More Effectively Neutralizes Psoriasis-Associated Histologic, Transcriptomic, and Clinical Measures than Ustekinumab by Campbell, Kim, Li, Katherine, Yang, Feifei, Branigan, Patrick, Elloso, M Merle, Benson, Jacqueline, Orlovsky, Yevgeniya, Chen, Yanqing, Garcet, Sandra, Krueger, James G

“…Given the key role of the IL-23/Th17 axis in the pathogenesis of moderate-to-severe plaque psoriasis, several specific inhibitors of the p19 subunit of IL-23…”
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Suppression of experimental autoimmune encephalomyelitis using estrogen receptor-selective ligands by Elloso, M Merle, Phiel, Kristen, Henderson, Ruth A, Harris, Heather A, Adelman, Steven J

“…Estrogens have been shown to modulate disease activity in experimental autoimmune encephalomyelitis (EAE), the mouse model for multiple sclerosis. Consistent…”
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The role of interchain disulfide bond in a recombinant human interleukin-17A variant by Wu, Bingyuan, Muzammil, Salman, Jones, Brian, Nemeth, Jennifer F., Janecki, Dariusz J., Baker, Audrey, Merle Elloso, M., Naso, Michael, Carton, Jill, Taudte, Susann

“…•Refolding of a human interleukin-17A (IL-17A) variant results in covalent and non-covalent dimers.•The interchain disulfide is not essential for IL-17A…”
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Protective Effect of the Immunosuppressant Sirolimus Against Aortic Atherosclerosis In Apo E‐Deficient Mice by Elloso, M. Merle, Azrolan, Neal, Sehgal, Suren N., Hsu, Pa‐Lang, Phiel, Kristen L., Kopec, Caroline A., Basso, Michael D., Adelman, Steven J.

“…Atherosclerosis is a chronic inflammatory disease that develops in response to injury to the vessel wall, and is augmented by hypercholesterolemia. To further…”
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Combined Blockade of TNF-α and IL-17A Alleviates Progression of Collagen-Induced Arthritis without Causing Serious Infections in Mice by Shen, Fang, Verma, Akash H, Volk, Amy, Jones, Brian, Coleman, Bianca M, Loza, Matthew J, Malaviya, Ravi, Moore, Beverley, Weinstock, Daniel, Elloso, M Merle, Gaffen, Sarah L, Ort, Tatiana

“…The cytokines TNF-α and IL-17A are elevated in a variety of autoimmune diseases, including rheumatoid arthritis. Both cytokines are targets of several biologic…”
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Negative regulation of IL-17 production by OX40/OX40L interaction by Li, Jian, Li, Li, Shang, XiaoZhou, Benson, Jacqueline, Merle Elloso, M., Schantz, Allen, Bracht, Michelle, Orlovsky, Yevgeniya, Sweet, Ray

“…The T-cell cytokine IL-17 is implicated in multiple inflammatory diseases through its induction of several pro-inflammatory cytokines and chemokines in a broad…”
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Differential estrogen receptor gene expression in human peripheral blood mononuclear cell populations by Phiel, Kristen L., Henderson, Ruth A., Adelman, Steven J., Elloso, M. Merle

“…Estrogens have been shown to modulate immune responses. Several studies have demonstrated the capacity of T cells, B cells, and monocytes to respond to…”
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Proinflammatory/profibrotic effects of interleukin-17A on human proximal tubule epithelium by Dudas, Paul L, Sague, Sarah L, Elloso, M Merle, Farrell, Francis X

“…Interleukin-17A (IL-17A) is a T cell-derived inflammatory cytokine that is upregulated during renal allograft rejection. The present study sought to further…”
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Expression, refolding and purification of a human interleukin-17A variant by Wu, Bingyuan, Nemeth, Jennifer F., Janecki, Dariusz J., Jones, Brian, Obmolova, Galina, Malia, Thomas J., Baker, Audrey, Bethea, Deidra, Elloso, M. Merle, Naso, Michael, Taudte, Susann

“…A human interleukin-17A (IL-17A) variant was overexpressed in Escherichia coli BL21 (DE3) under the control of a T7 promoter. The resulting insoluble inclusion…”
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Differential requirement of CD28 for IL‐12 receptor expression and function in CD4+ and CD8+ T cells by Elloso, M. Merle, Scott, Phillip

“…IL‐12 is a potent inducer of IFN‐γ production and Th1 responses. Co‐stimulation mediated by B7 has been shown to synergize with IL‐12 for optimal IFN‐γ…”
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Maintenance of IL‐12‐responsive CD4+ T cells during a Th2 response in Leishmania major‐infected mice by Hondowicz, Brian D., Park, Audrey Y., Merle Elloso, M., Scott, Phillip

“…BALB / c and anti‐IL‐12‐treated C3H mice infected with Leishmania major develop a Th2 cell response. However, in contrast to BALB / c mice, C3H mice treated…”
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Differential Regulation of the Interleukin-12 Receptor during the Innate Immune Response to Leishmania major by JONES, D, ELLOSO, M. M, SHOWE, L, WILLIAMS, D, TRINCHIERI, G, SCOTT, P

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