Search Results - "Ellmerich, Stéphan"

Promotion of intestinal carcinogenesis by Streptococcus bovis by Ellmerich, Stéphan, Schöller, Marie, Duranton, Benoît, Gossé, Francine, Galluser, Michel, Klein, Jean-Paul, Raul, Francis

“…The involvement of Streptococcus bovis, an member of the human gut flora, in colorectal neoplastic diseases is an object of controversy. The aim of this study…”
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Systemic Exosomal Delivery of shRNA Minicircles Prevents Parkinsonian Pathology by Izco, María, Blesa, Javier, Schleef, Martin, Schmeer, Marco, Porcari, Riccardo, Al-Shawi, Raya, Ellmerich, Stephan, de Toro, María, Gardiner, Chris, Seow, Yiqi, Reinares-Sebastian, Alejandro, Forcen, Raquel, Simons, J. Paul, Bellotti, Vittorio, Cooper, J. Mark, Alvarez-Erviti, Lydia

“…The development of new therapies to slow down or halt the progression of Parkinson’s disease is a health care priority. A key pathological feature is the…”
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Plasmin activity promotes amyloid deposition in a transgenic model of human transthyretin amyloidosis by Slamova, Ivana, Adib, Rozita, Ellmerich, Stephan, Golos, Michal R., Gilbertson, Janet A., Botcher, Nicola, Canetti, Diana, Taylor, Graham W., Rendell, Nigel, Tennent, Glenys A., Verona, Guglielmo, Porcari, Riccardo, Mangione, P. Patrizia, Gillmore, Julian D., Pepys, Mark B., Bellotti, Vittorio, Hawkins, Philip N., Al-Shawi, Raya, Simons, J. Paul

“…Cardiac ATTR amyloidosis, a serious but much under-diagnosed form of cardiomyopathy, is caused by deposition of amyloid fibrils derived from the plasma protein…”
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Pathogenetic mechanisms of amyloid A amyloidosis by Simons, J. Paul, Al-Shawib, Raya, Ellmerich, Stephan, Speck, Ivana, Aslam, Samrina, Hutchinson, Winston L., Mangione, Palma P., Disterer, Petra, Gilbertson, Janet A., Hunt, Toby, Millar, David J., Minogue, Shane, Bodin, Karl, Pepys, Mark B., Hawkins, Philip N.

“…Systemic amyloid A (AA) amyloidosis is a serious complication of chronic inflammation. Serum AA protein (SAA), an acute phase plasma protein, is deposited…”
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Genetic evidence for serum amyloid P component as a drug target in neurodegenerative disorders by Schmidt, A Floriaan, Finan, Chris, Chopade, Sandesh, Ellmerich, Stephan, Rossor, Martin N, Hingorani, Aroon D, Pepys, Mark B

“…The mechanisms responsible for neuronal death causing cognitive loss in Alzheimer's disease (AD) and many other dementias are not known. Serum amyloid P…”
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Requirement for complement in antibody responses is not explained by the classic pathway activator IgM by Rutemark, Christian, Alicot, Elisabeth, Bergman, Anna, Ma, Minghe, Getahun, Andrew, Ellmerich, Stephan, Carroll, Michael C, Heyman, Birgitta

“…Animals lacking complement factors C1q, C2, C3, or C4 have severely impaired Ab responses, suggesting a major role for the classic pathway. The classic pathway…”
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A specific nanobody prevents amyloidogenesis of D76N β2-microglobulin in vitro and modifies its tissue distribution in vivo by Raimondi, Sara, Porcari, Riccardo, Mangione, P. Patrizia, Verona, Guglielmo, Marcoux, Julien, Giorgetti, Sofia, Taylor, Graham W., Ellmerich, Stephan, Ballico, Maurizio, Zanini, Stefano, Pardon, Els, Al-Shawi, Raya, Simons, J. Paul, Corazza, Alessandra, Fogolari, Federico, Leri, Manuela, Stefani, Massimo, Bucciantini, Monica, Gillmore, Julian D., Hawkins, Philip N., Valli, Maurizia, Stoppini, Monica, Robinson, Carol V., Steyaert, Jan, Esposito, Gennaro, Bellotti, Vittorio

“…Systemic amyloidosis is caused by misfolding and aggregation of globular proteins in vivo for which effective treatments are urgently needed. Inhibition of…”
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Protein Engineered Variants of Hepatocyte Growth Factor/Scatter Factor Promote Proliferation of Primary Human Hepatocytes and in Rodent Liver by Ross, Jacob, Gherardi, Ermanno, Mallorqui–Fernandez, Noemi, Bocci, Marco, Sobkowicz, Anna, Rees, Myrrdin, Rowe, Arthur, Ellmerich, Stephan, Massie, Isobel, Soeda, Junpei, Selden, Clare, Hodgson, Humphrey

“…Background & Aims Hepatocyte growth factor/scatter factor (HGF/SF) stimulates hepatocyte DNA synthesis and protects against apoptosis; in vivo it promotes…”
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High Incidence of Spontaneous Disease in an HLA-DR15 and TCR Transgenic Multiple Sclerosis Model by Ellmerich, Stephan, Mycko, Marcin, Takacs, Katalin, Waldner, Hanspeter, Wahid, Faisal N, Boyton, Rosemary J, King, Rosalind H. M, Smith, Paul A, Amor, Sandra, Herlihy, Amy H, Hewitt, Rachel E, Jutton, Mark, Price, David A, Hafler, David A, Kuchroo, Vijay K, Altmann, Daniel M

“…Multiple sclerosis (MS) is thought to involve CD4 T cell recognition of self myelin, many studies focusing on a pathogenic role for anti-myelin,…”
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Bifunctional crosslinking ligands for transthyretin by Mangione, P. Patrizia, Deroo, Stéphanie, Ellmerich, Stephan, Bellotti, Vittorio, Kolstoe, Simon, Wood, Stephen P., Robinson, Carol V., Smith, Martin D., Tennent, Glenys A., Broadbridge, Robert J., Council, Claire E., Thurston, Joanne R., Steadman, Victoria A., Vong, Antonio K., Swain, Christopher J., Pepys, Mark B., Taylor, Graham W.

“…Wild-type and variant forms of transthyretin (TTR), a normal plasma protein, are amyloidogenic and can be deposited in the tissues as amyloid fibrils causing…”
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Modified Amino Acid Copolymers Suppress Myelin Basic Protein 85-99-Induced Encephalomyelitis in Humanized Mice through Different Effects on T Cells by Illés, Zsolt, Joel N. H. Stern, Reddy, Jayagopala, Waldner, Hanspeter, Mycko, Marcin P., Brosnan, Celia F., Ellmerich, Stephan, Altmann, Daniel M., Santambrogio, Laura, Strominger, Jack L., Kuchroo, Vijay K.

“…A humanized mouse bearing the HLA-DR2 (DRA/DRB1*1501) protein associated with multiple sclerosis (MS) and the myelin basic protein (MBP) 85-99-specific…”
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Equilibrium contrast CMR for the detection of amyloidosis in mice by Campbell, Adrienne E, Price, Anthony N, Ellmerich, Stephan, Simons, Paul, Al-Shawi, Raya, Hawkins, Philip N, Ordidge, Roger J, Pepys, Mark B, Moon, James C, Lythgoe, Mark F

“…From: 2011 SCMR/Euro CMR Joint Scientific Sessions Nice, France 3-6 February 2011 Author details1-Centre for Advanced Biomedical Imaging, University College…”
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Antibody-Associated Reversal of ATTR Amyloidosis–Related Cardiomyopathy by Fontana, Marianna, Gilbertson, Janet, Verona, Guglielmo, Riefolo, Mattia, Slamova, Ivana, Leone, Ornella, Rowczenio, Dorota, Botcher, Nicola, Ioannou, Adam, Patel, Rishi K., Razvi, Yousuf, Martinez-Naharro, Ana, Whelan, Carol J., Venneri, Lucia, Duhlin, Amanda, Canetti, Diana, Ellmerich, Stephan, Moon, James C., Kellman, Peter, Al-Shawi, Raya, McCoy, Laura, Simons, J. Paul, Hawkins, Philip N., Gillmore, Julian D.

“…The investigators describe antibodies that bound amyloid in three patients with transthyretin amyloidosis. Spontaneous regression of cardiomyopathy occurred in…”
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Antibodies to human serum amyloid P component eliminate visceral amyloid deposits by Pepys, Mark B, Bodin, Karl, Ellmerich, Stephan, Kahan, Melvyn C, Tennent, Glenys A, Loesch, Andrzej, Gilbertson, Janet A, Hutchinson, Winston L, Mangione, Palma P, Gallimore, J. Ruth, Millar, David J, Minogue, Shane, Dhillon, Amar P, Taylor, Graham W, Bradwell, Arthur R, Petrie, Aviva, Gillmore, Julian D, Bellotti, Vittorio, Botto, Marina, Hawkins, Philip N

“…Accumulation of amyloid fibrils in the viscera and connective tissues causes systemic amyloidosis, which is responsible for about one in a thousand deaths in…”
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Exon Skipping of Hepatic APOB Pre-mRNA With Splice-switching Oligonucleotides Reduces LDL Cholesterol In Vivo by Disterer, Petra, Al-Shawi, Raya, Ellmerich, Stephan, Waddington, Simon N, Owen, James S, Simons, J Paul, Khoo, Bernard

“…Familial hypercholesterolemia (FH) is a genetic disorder characterized by extremely high levels of plasma low-density lipoprotein (LDL), due to defective LDL…”
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C‐reactive protein is essential for innate resistance to pneumococcal infection by Paul Simons, J., Loeffler, Jutta M., Al‐Shawi, Raya, Ellmerich, Stephan, Hutchinson, Winston L., Tennent, Glenys A., Petrie, Aviva, Raynes, John G., Souza, J. Brian, Lawrence, Rachel A., Read, Kevin D., Pepys, Mark B.

“…Summary No deficiency of human C‐reactive protein (CRP), or even structural polymorphism of the protein, has yet been reported so its physiological role is not…”
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Isolation and characterization of pharmaceutical grade human pentraxins, serum amyloid P component and C‐reactive protein, for clinical use by Pepys, Mark B., Gallimore, J. Ruth, Lloyd, Joanne, Li, Zhanhong, Graham, David, Taylor, Graham W., Ellmerich, Stephan, Mangione, Palma P., Tennent, Glenys A., Hutchinson, Winston L., Millar, David J., Bennett, Gary, More, John, Evans, David, Mistry, Yogesh, Poole, Stephen, Hawkins, Philip N.

“…The human pentraxin proteins, serum amyloid P component (SAP) and C‐reactive protein (CRP) are important in routine clinical diagnosis, SAP for systemic…”
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Dementia in the older population is associated with neocortex content of serum amyloid P component by Ellmerich, Stephan, Taylor, Graham W, Richardson, Connor D, Minett, Thais, Schmidt, Amand Floriaan, Brayne, Carol, Matthews, Fiona E, Ince, Paul G, Wharton, Stephen B, Pepys, Mark B

“…Abstract Despite many reported associations, the direct cause of neurodegeneration responsible for cognitive loss in Alzheimer’s disease and some other common…”
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Amyloid persistence in decellularized liver: biochemical and histopathological characterization by Mazza, Giuseppe, Simons, J. Paul, Al-Shawi, Raya, Ellmerich, Stephan, Urbani, Luca, Giorgetti, Sofia, Taylor, Graham W., Gilbertson, Janet A., Hall, Andrew R., Al-Akkad, Walid, Dhar, Dipok, Hawkins, Philip N., De Coppi, Paolo, Pinzani, Massimo, Bellotti, Vittorio, Mangione, P. Patrizia

“…Systemic amyloidoses are a group of debilitating and often fatal diseases in which fibrillar protein aggregates are deposited in the extracellular spaces of a…”
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Sexual dimorphism in superantigen shock involves elevated TNF-α and TNF-α-induced hepatic apoptosis by FAULKNER, Lee, ALTMANN, Daniel M, ELLMERICH, Stephan, HUHTANIEMI, Llpo, STAMP, Gordon, SRISKANDAN, Shiranee

“…There is conflicting evidence regarding sex differences in the outcome from severe sepsis and toxic shock. Superantigen-mediated toxic shock affects a higher…”
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