Search Results - "Ellisman, Mark H"

Ultrastructural evidence for synaptic scaling across the wake/sleep cycle by de Vivo, Luisa, Bellesi, Michele, Marshall, William, Bushong, Eric A., Ellisman, Mark H., Tononi, Giulio, Cirelli, Chiara

“…It is assumed that synaptic strengthening and weakening balance throughout learning to avoid runaway potentiation and memory interference. However, energetic…”
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ChromEMT: Visualizing 3D chromatin structure and compaction in interphase and mitotic cells by Ou, Horng D., Phan, Sébastien, Deerinck, Thomas J., Thor, Andrea, Ellisman, Mark H., O’Shea, Clodagh C.

“…The chromatin structure of DNA determines genome compaction and activity in the nucleus. On the basis of in vitro structures and electron microscopy (EM)…”
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Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet by Hatori, Megumi, Vollmers, Christopher, Zarrinpar, Amir, DiTacchio, Luciano, Bushong, Eric A., Gill, Shubhroz, Leblanc, Mathias, Chaix, Amandine, Joens, Matthew, Fitzpatrick, James A.J., Ellisman, Mark H., Panda, Satchidananda

“…While diet-induced obesity has been exclusively attributed to increased caloric intake from fat, animals fed a high-fat diet (HFD) ad libitum (ad lib) eat…”
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Directed evolution of APEX2 for electron microscopy and proximity labeling by Lam, Stephanie S, Martell, Jeffrey D, Kamer, Kimberli J, Deerinck, Thomas J, Ellisman, Mark H, Mootha, Vamsi K, Ting, Alice Y

“…A genetically encoded peroxidase with improved sensitivity, APEX2, is reported for electron microscopy and proximity labeling at low expression levels. APEX is…”
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NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria by Zhong, Zhenyu, Umemura, Atsushi, Sanchez-Lopez, Elsa, Liang, Shuang, Shalapour, Shabnam, Wong, Jerry, He, Feng, Boassa, Daniela, Perkins, Guy, Ali, Syed Raza, McGeough, Matthew D., Ellisman, Mark H., Seki, Ekihiro, Gustafsson, Asa B., Hoffman, Hal M., Diaz-Meco, Maria T., Moscat, Jorge, Karin, Michael

“…Nuclear factor κB (NF-κB), a key activator of inflammation, primes the NLRP3-inflammasome for activation by inducing pro-IL-1β and NLRP3 expression. NF-κB,…”
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Chromothripsis drives the evolution of gene amplification in cancer by Shoshani, Ofer, Brunner, Simon F., Yaeger, Rona, Ly, Peter, Nechemia-Arbely, Yael, Kim, Dong Hyun, Fang, Rongxin, Castillon, Guillaume A., Yu, Miao, Li, Julia S. Z., Sun, Ying, Ellisman, Mark H., Ren, Bing, Campbell, Peter J., Cleveland, Don W.

“…Focal chromosomal amplification contributes to the initiation of cancer by mediating overexpression of oncogenes 1 – 3 , and to the development of cancer…”
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Conditions and Constraints for Astrocyte Calcium Signaling in the Hippocampal Mossy Fiber Pathway by Haustein, Martin D., Kracun, Sebastian, Lu, Xiao-Hong, Shih, Tiffany, Jackson-Weaver, Olan, Tong, Xiaoping, Xu, Ji, Yang, X. William, O’Dell, Thomas J., Marvin, Jonathan S., Ellisman, Mark H., Bushong, Eric A., Looger, Loren L., Khakh, Baljit S.

“…The spatiotemporal activities of astrocyte Ca2+ signaling in mature neuronal circuits remain unclear. We used genetically encoded Ca2+ and glutamate indicators…”
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Development of a Method for the Purification and Culture of Rodent Astrocytes by Foo, Lynette C., Allen, Nicola J., Bushong, Eric A., Ventura, P. Britten, Chung, Won-Suk, Zhou, Lu, Cahoy, John D., Daneman, Richard, Zong, Hui, Ellisman, Mark H., Barres, Ben A.

“…The inability to purify and culture astrocytes has long hindered studies of their function. Whereas astrocyte progenitor cells can be cultured from neonatal…”
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A genetically encoded tag for correlated light and electron microscopy of intact cells, tissues, and organisms by Shu, Xiaokun, Lev-Ram, Varda, Deerinck, Thomas J, Qi, Yingchuan, Ramko, Ericka B, Davidson, Michael W, Jin, Yishi, Ellisman, Mark H, Tsien, Roger Y

“…Electron microscopy (EM) achieves the highest spatial resolution in protein localization, but specific protein EM labeling has lacked generally applicable…”
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Basal autophagy maintains pancreatic acinar cell homeostasis and protein synthesis and prevents ER stress by Antonucci, Laura, Fagman, Johan B., Kim, Ju Youn, Todoric, Jelena, Gukovsky, Ilya, Mackey, Mason, Ellisman, Mark H., Karin, Michael

“…Pancreatic acinar cells possess very high protein synthetic rates as they need to produce and secrete large amounts of digestive enzymes. Acinar cell damage…”
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Dedifferentiation of Neurons and Astrocytes by Oncogenes Can Induce Gliomas in Mice by Friedmann-Morvinski, Dinorah, Bushong, Eric A., Ke, Eugene, Soda, Yasushi, Marumoto, Tomotoshi, Singer, Oded, Ellisman, Mark H., Verma, Inder M.

“…Glioblastoma multiforme (GBM) is the most common and aggressive malignant primary brain tumor in humans. Here we show that gliomas can originate from…”
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Proteomic Analysis of Unbounded Cellular Compartments: Synaptic Clefts by Loh, Ken H., Stawski, Philipp S., Draycott, Austin S., Udeshi, Namrata D., Lehrman, Emily K., Wilton, Daniel K., Svinkina, Tanya, Deerinck, Thomas J., Ellisman, Mark H., Stevens, Beth, Carr, Steven A., Ting, Alice Y.

“…Cellular compartments that cannot be biochemically isolated are challenging to characterize. Here we demonstrate the proteomic characterization of the synaptic…”
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Design and synthesis of a minimal bacterial genome by Hutchison, Clyde A., Chuang, Ray-Yuan, Noskov, Vladimir N., Assad-Garcia, Nacyra, Deerinck, Thomas J., Ellisman, Mark H., Gill, John, Kannan, Krishna, Karas, Bogumil J., Ma, Li, Pelletier, James F., Qi, Zhi-Qing, Richter, R. Alexander, Strychalski, Elizabeth A., Sun, Lijie, Suzuki, Yo, Tsvetanova, Billyana, Wise, Kim S., Smith, Hamilton O., Glass, John I., Merryman, Chuck, Gibson, Daniel G., Venter, J. Craig

“…We used whole-genome design and complete chemical synthesis to minimize the 1079-kilobase pair synthetic genome of Mycoplasma mycoides JCVI-syn1.0. An initial…”
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Transcellular degradation of axonal mitochondria by Davis, Chung-ha O., Kim, Keun-Young, Bushong, Eric A., Mills, Elizabeth A., Boassa, Daniela, Shih, Tiffany, Kinebuchi, Mira, Phan, Sebastien, Zhou, Yi, Bihlmeyer, Nathan A., Nguyen, Judy V., Jin, Yunju, Ellisman, Mark H., Marsh-Armstrong, Nicholas

“…It is generally accepted that healthy cells degrade their own mitochondria. Here, we report that retinal ganglion cell axons of WT mice shed mitochondria at…”
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Electron microscopy using the genetically encoded APEX2 tag in cultured mammalian cells by Martell, Jeffrey D, Deerinck, Thomas J, Lam, Stephanie S, Ellisman, Mark H, Ting, Alice Y

“…This protocol describes procedures for using the genetic tag APEX2 to generate contrast for electron microscopy in cultured cells. Electron microscopy (EM) is…”
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Activity-dependent trafficking of lysosomes in dendrites and dendritic spines by Goo, Marisa S, Sancho, Laura, Slepak, Natalia, Boassa, Daniela, Deerinck, Thomas J, Ellisman, Mark H, Bloodgood, Brenda L, Patrick, Gentry N

“…In neurons, lysosomes, which degrade membrane and cytoplasmic components, are thought to primarily reside in somatic and axonal compartments, but there is…”
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A split horseradish peroxidase for the detection of intercellular protein–protein interactions and sensitive visualization of synapses by Martell, Jeffrey D, Yamagata, Masahito, Deerinck, Thomas J, Phan, Sébastien, Kwa, Carolyn G, Ellisman, Mark H, Sanes, Joshua R, Ting, Alice Y

“…Synapses can be detected with high sensitivity by a split reporter that visualizes intercellular protein–protein interactions. Intercellular protein–protein…”
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Replication-dependent size reduction precedes differentiation in Chlamydia trachomatis by Lee, Jennifer K., Enciso, Germán A., Boassa, Daniela, Chander, Christopher N., Lou, Tracy H., Pairawan, Sean S., Guo, Melody C., Wan, Frederic Y. M., Ellisman, Mark H., Sütterlin, Christine, Tan, Ming

“…Chlamydia trachomatis is the most common cause of bacterial sexually transmitted infection. It produces an unusual intracellular infection in which a…”
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Molecular composition and ultrastructure of the caveolar coat complex by Ludwig, Alexander, Howard, Gillian, Mendoza-Topaz, Carolina, Deerinck, Thomas, Mackey, Mason, Sandin, Sara, Ellisman, Mark H, Nichols, Benjamin J

“…Caveolae are an abundant feature of the plasma membrane of many mammalian cell types, and have key roles in mechano-transduction, metabolic regulation, and…”
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Cadherin-9 Regulates Synapse-Specific Differentiation in the Developing Hippocampus by Williams, Megan E., Wilke, Scott A., Daggett, Anthony, Davis, Elizabeth, Otto, Stefanie, Ravi, Deepak, Ripley, Beth, Bushong, Eric A., Ellisman, Mark H., Klein, Gerd, Ghosh, Anirvan

“…Our understanding of mechanisms that regulate the differentiation of specific classes of synapses is limited. Here, we investigate the formation of synapses…”
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