Search Results - "Ellis J. Neufeld"

Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions by Neufeld, Ellis J.

“…For nearly 30 years, patients with transfusional iron overload have depended on nightly deferoxamine infusions for iron chelation. Despite dramatic gains in…”
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Novel therapeutics and future directions for refractory immune thrombocytopenia by Al-Samkari, Hanny, Neufeld, Ellis J

“…Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder affecting approximately 1 in 20 000 people. While most patients with ITP are successfully…”
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Asymptomatic and Symptomatic SARS-CoV-2 Infections After BNT162b2 Vaccination in a Routinely Screened Workforce by Tang, Li, Hijano, Diego R, Gaur, Aditya H, Geiger, Terrence L, Neufeld, Ellis J, Hoffman, James M, Hayden, Randall T

“…A 2-dose regimen of the BNT162b2 vaccine (Pfizer-BioNTech) against SARS-CoV-2 was authorized in Dec 2020 based on reported 94.8% efficacy. Although an…”
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Erythrocyte pyruvate kinase deficiency: 2015 status report by Grace, Rachael F., Zanella, Alberto, Neufeld, Ellis J., Morton, D. Holmes, Eber, Stefan, Yaish, Hassan, Glader, Bertil

“…Over the last several decades, our understanding of the genetic variation, pathophysiology, and complications of the hemolytic anemia associated with red cell…”
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Prevalence and management of iron overload in pyruvate kinase deficiency: report from the Pyruvate Kinase Deficiency Natural History Study by van Beers, Eduard J, van Straaten, Stephanie, Morton, D Holmes, Barcellini, Wilma, Eber, Stefan W, Glader, Bertil, Yaish, Hassan M, Chonat, Satheesh, Kwiatkowski, Janet L, Rothman, Jennifer A, Sharma, Mukta, Neufeld, Ellis J, Sheth, Sujit, Despotovic, Jenny M, Kollmar, Nina, Pospíšilová, Dagmar, Knoll, Christine M, Kuo, Kevin, Pastore, Yves D, Thompson, Alexis A, Newburger, Peter E, Ravindranath, Yaddanapudi, Wang, Winfred C, Wlodarski, Marcin W, Wang, Heng, Holzhauer, Susanne, Breakey, Vicky R, Verhovsek, Madeleine, Kunz, Joachim, McNaull, Melissa A, Rose, Melissa J, Bradeen, Heather A, Addonizio, Kathryn, Li, Anran, Al-Sayegh, Hasan, London, Wendy B, Grace, Rachael F

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Pediatric Heparin-Induced Thrombocytopenia: Prevalence, Thrombotic Risk, and Application of the 4Ts Scoring System by Obeng, Esther A., MD, PhD, Harney, Kathy M., C-PNP, Moniz, Thomas, PharmD, Arnold, Alana, PharmD, BCPS, Neufeld, Ellis J., MD, PhD, Trenor, Cameron C., MD

“…Objective To characterize heparin-induced thrombocytopenia (HIT) at a single pediatric center including the prevalence and the accuracy of the 4Ts scoring…”
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Which pediatric ITP patients will go on to lupus? by Neufeld, Ellis J.

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Safety update on the use of recombinant activated factor VII in approved indications by Neufeld, Ellis J, Négrier, Claude, Arkhammar, Per, el Fegoun, Soraya Benchikh, Simonsen, Mette Duelund, Rosholm, Anders, Seremetis, Stephanie

“…Abstract This updated safety review summarises the large body of safety data available on the use of recombinant activated factor VII (rFVIIa) in approved…”
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Systematic molecular genetic analysis of congenital sideroblastic anemia: Evidence for genetic heterogeneity and identification of novel mutations by Bergmann, Anke K., Campagna, Dean R., McLoughlin, Erin M., Agarwal, Suneet, Fleming, Mark D., Bottomley, Sylvia S., Neufeld, Ellis J.

“…Background Sideroblastic anemias are heterogeneous congenital and acquired bone marrow disorders characterized by pathologic iron deposits in mitochondria of…”
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Risk of Post-Procedural Bleeding in Children on Intravenous Fish Oil by Nandivada, Prathima, MD, Anez-Bustillos, Lorenzo, MD, O’Loughlin, Alison A., MEd, Mitchell, Paul D., MSc, Baker, Meredith A., MD, Dao, Duy T., MD, Fell, Gillian L., MD PhD, Potemkin, Alexis K., BSN, Gura, Kathleen M., PharmD, Neufeld, Ellis J., MD PhD, Puder, Mark, MD PhD

“…ABSTRACT Background Intestinal failure-associated liver disease (IFALD) can be treated with parenteral fish oil (FO) monotherapy, but practitioners have raised…”
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Phase 3 randomised trial of eltrombopag versus standard first-line pharmacological management for newly diagnosed immune thrombocytopaenia (ITP) in children: study protocol by Shimano, Kristin A, Grace, Rachael F, Despotovic, Jenny M, Neufeld, Ellis J, Klaassen, Robert J, Bennett, Carolyn M, Ma, Clement, London, Wendy B, Neunert, Cindy

“…IntroductionImmune thrombocytopaenia (ITP) is an acquired disorder of low platelets and risk of bleeding. Although many children can be observed until…”
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Increasing observation rates in low‐risk pediatric immune thrombocytopenia using a standardized clinical assessment and management plan (SCAMP®) by Schoettler, Michelle L., Graham, Dionne, Tao, Wen, Stack, Margaret, Shu, Elaine, Kerr, Lauren, Neufeld, Ellis J., Grace, Rachael F.

“…An observational approach is recommended in newly diagnosed children with immune thrombocytopenia (ITP) at low risk of bleeding; however, there is no standard…”
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Prospective longitudinal study of coagulation profiles in children with hypoplastic left heart syndrome from stage I through Fontan completion by Odegard, Kirsten C., MD, Zurakowski, David, PhD, DiNardo, James A., MD, Castro, Robert A., MT, McGowan, Francis X., MD, Neufeld, Ellis J., MD, Laussen, Peter C., MBBS

“…Objective The risk for thrombosis is increased after the Fontan operation. It is unknown whether children with univentricular heart disease have an intrinsic…”
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X-linked gray platelet syndrome due to a GATA1 Arg216Gln mutation by Tubman, Venée N., Levine, Jason E., Campagna, Dean R., Monahan-Earley, Rita, Dvorak, Ann M., Neufeld, Ellis J., Fleming, Mark D.

“…We identified a family with gray platelet syndrome (GPS) segregating as a sex-linked trait. Affected males had a mild bleeding disorder, thrombocytopenia, and…”
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Does iron overload really matter in stem cell transplantation? by Armand, Philippe, Sainvil, Marie-Michele, Kim, Haesook T., Rhodes, Joanna, Cutler, Corey, Ho, Vincent T., Koreth, John, Alyea, Edwin P., Neufeld, Ellis J., Kwong, Raymond Y., Soiffer, Robert J., Antin, Joseph H.

“…A growing body of evidence suggests that iron overload is associated with inferior outcomes after myeloablative allogeneic hematopoietic stem cell…”
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Effect of Acute Bleeding on Daily Quality of Life Assessments in Patients with Congenital Hemophilia with Inhibitors and Their Families: Observations from the Dosing Observational Study in Hemophilia by Neufeld, Ellis J., MD, PhD, Recht, Michael, MD, PhD, Sabio, Hernan, MD, Saxena, Kapil, MD, Solem, Caitlyn T., PhD, Pickard, A. Simon, PhD, Gut, Robert Z., MD, PhD, Cooper, David L., MD, MBA

“…Abstract Introduction Quality-of-life (QOL) assessments in frequently bleeding patients with congenital hemophilia with inhibitors and their families are…”
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Bioengineering hemophilia A–specific microvascular grafts for delivery of full-length factor VIII into the bloodstream by Neumeyer, Joseph, Lin, Ruei-Zeng, Wang, Kai, Hong, Xuechong, Hua, Tien, Croteau, Stacy E., Neufeld, Ellis J., Melero-Martin, Juan M.

“…Hemophilia A (HA) is a bleeding disorder caused by mutations in the F8 gene encoding coagulation factor VIII (FVIII). Current treatments are based on regular…”
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Inadequate Dietary Intake in Patients with Thalassemia by Fung, Ellen B., PhD, RD, Xu, Yan, MS, Trachtenberg, Felicia, PhD, Odame, Isaac, MD, Kwiatkowski, Janet L., MD, MSCE, Neufeld, Ellis J., MD, PhD, Thompson, Alexis A., MD, Boudreaux, Jeanne, MD, Quinn, Charles T., MD, MS, Vichinsky, Elliott P., MD

“…Abstract Background Patients with thalassemia have low circulating levels of many nutrients, but the contribution of dietary intake has not been assessed…”
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Thiamine-Responsive Megaloblastic Anemia: Identification of Novel Compound Heterozygotes and Mutation Update by Bergmann, Anke K., MD, PhD, Sahai, Inderneel, MD, Falcone, Jill F., BS, Fleming, Judy, PhD, Bagg, Adam, MD, Borgna-Pignati, Caterina, MD, Casey, Robin, MD, Fabris, Luca, MD, PhD, Hexner, Elizabeth, MD, Mathews, Lulu, MD, Ribeiro, Maria Leticia, MD, PhD, Wierenga, Klaas J., MD, Neufeld, Ellis J., MD, PhD

“…Objective To determine causative mutations and clinical status of 7 previously unreported kindreds with TRMA syndrome, (thiamine-responsive megaloblastic…”
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MRI guided iron assessment and oral chelator use improve iron status in thalassemia major patients by Nichols‐Vinueza, Diana X., White, Matthew T., Powell, Andrew J., Banka, Puja, Neufeld, Ellis J.

“…Oral iron chelators and magnetic resonance imaging (MRI) assessment of heart and liver iron burden have become widely available since the mid 2000s, allowing…”
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