Search Results - "Ellis, Randall J."

Chemogenetics revealed: DREADD occupancy and activation via converted clozapine by Gomez, Juan L., Bonaventura, Jordi, Lesniak, Wojciech, Mathews, William B., Sysa-Shah, Polina, Rodriguez, Lionel A., Ellis, Randall J., Richie, Christopher T., Harvey, Brandon K., Dannals, Robert F., Pomper, Martin G., Bonci, Antonello, Michaelides, Michael

“…The chemogenetic technology DREADD (designer receptors exclusively activated by designer drugs) is widely used for remote manipulation of neuronal activity in…”
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Specification curve analysis to identify heterogeneity in risk factors for dementia: findings from the UK Biobank by Luo, Renhao, Zeraatkar, Dena, Glymour, Maria, Ellis, Randall J, Estiri, Hossein, Patel, Chirag J

“…In 2020, the Lancet Commission identified 12 risk factors as priorities for prevention of dementia, and other studies identified APOE e4/e4 genotype and family…”
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Predicting opioid dependence from electronic health records with machine learning by Ellis, Randall J, Wang, Zichen, Genes, Nicholas, Ma'ayan, Avi

“…The opioid epidemic in the United States is averaging over 100 deaths per day due to overdose. The effectiveness of opioids as pain treatments, and the…”
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Synaptic Zn2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior by Gomez, Juan L., Bonaventura, Jordi, Keighron, Jacqueline, Wright, Kelsey M., Marable, Dondre L., Rodriguez, Lionel A., Lam, Sherry, Carlton, Meghan L., Ellis, Randall J., Jordan, Chloe J., Bi, Guo-hua, Solis, Oscar, Pignatelli, Marco, Bannon, Michael J., Xi, Zheng-Xiong, Tanda, Gianluigi, Michaelides, Michael

“…Cocaine binds to the dopamine (DA) transporter (DAT) to regulate cocaine reward and seeking behavior. Zinc (Zn 2+ ) also binds to the DAT, but the in vivo…”
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Questionable Research Practices, Low Statistical Power, and Other Obstacles to Replicability: Why Preclinical Neuroscience Research Would Benefit from Registered Reports by Ellis, Randall J

“…Replicability, the degree to which a previous scientific finding can be repeated in a distinct set of data, has been considered an integral component of…”
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SnapShot: Neurobiology of opioid use disorder by Ellis, Randall J., Rahman, Tanni, Sherman, Jeremy, Hurd, Yasmin L.

“…The use of opioid drugs and related overdose deaths, which rose to epidemic proportions over the past decade, have been exacerbated by the COVID pandemic, a…”
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bbeaR: an R package and framework for epitope-specific antibody profiling by Suprun, Maria, Ellis, Randall J, Sampson, Hugh A, Suárez-Fariñas, Mayte

“…Abstract Summary Analysis of epitope-specific antibody repertoires has provided novel insights into the pathogenesis of inflammatory disorders, especially…”
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Long-Term Outcomes of Adolescent THC Exposure on Translational Cognitive Measures in Adulthood in an Animal Model and Computational Assessment of Human Data by Ferland, Jacqueline-Marie N, Ellis, Randall J, Betts, Graeme, Silveira, Mason M, de Firmino, Joao Bronze, Winstanley, Catharine A, Hurd, Yasmin L

“…Although perceived as relatively harmless and nonaddictive, adolescent cannabis use significantly increases the likelihood of developing cannabis use disorder…”
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Dose mediates the protracted effects of adolescent THC exposure on reward and stress reactivity in males relevant to perturbation of the basolateral amygdala transcriptome by Ferland, Jacqueline-Marie N., Ellis, Randall J., Rompala, Gregory, Landry, Joseph A., Callens, James E., Ly, Annie, Frier, Micah D., Uzamere, Teddy O., Hurd, Yasmin L.

“…Despite the belief that cannabis is relatively harmless, exposure during adolescence is associated with increased risk of developing several psychopathologies…”
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Prenatal Δ9-Tetrahydrocannabinol Exposure in Males Leads to Motivational Disturbances Related to Striatal Epigenetic Dysregulation by Ellis, Randall J., Bara, Anissa, Vargas, Claudia A., Frick, Amy L., Loh, Eddie, Landry, Joseph, Uzamere, Teddy O., Callens, James E., Martin, Qammarah, Rajarajan, Prashanth, Brennand, Kristen, Ramakrishnan, Aarthi, Shen, Li, Szutorisz, Henrietta, Hurd, Yasmin L.

“…Cannabis remains one of the most widely abused drugs during pregnancy. In utero exposure to its principal psychoactive component, Δ9-tetrahydrocannabinol…”
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Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesity by Michaelides, Michael, Miller, Michael L., Egervari, Gabor, Primeaux, Stefany D., Gomez, Juan L., Ellis, Randall J., Landry, Joseph A., Szutorisz, Henrietta, Hoffman, Alexander F., Lupica, Carl R., Loos, Ruth J. F., Thanos, Panayotis K., Bray, George A., Neumaier, John F., Zachariou, Venetia, Wang, Gene-Jack, Volkow, Nora D., Hurd, Yasmin L.

“…Consumption of high fat, high sugar (western) diets is a major contributor to the current high levels of obesity. Here, we used a multidisciplinary approach to…”
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Data-Driven Investigations of Opioid Use Disorder: Clinical Risk Factors and Translational Targets by Ellis, Randall J

“…Opioid use disorder (OUD) claims the lives of over 189 Americans each day on average. Current medications are opioid replacement strategies fraught with many…”
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Twelve key challenges in medical machine learning and solutions by Ellis, Randall J., Sander, Ryan M., Limon, Alfonso

“…The utility of machine learning in biomedicine is being investigated in various contexts, including for diagnostic and interpretive purposes for imaging…”
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Prenatal Δ 9 -Tetrahydrocannabinol Exposure in Males Leads to Motivational Disturbances Related to Striatal Epigenetic Dysregulation by Ellis, Randall J, Bara, Anissa, Vargas, Claudia A, Frick, Amy L, Loh, Eddie, Landry, Joseph, Uzamere, Teddy O, Callens, James E, Martin, Qammarah, Rajarajan, Prashanth, Brennand, Kristen, Ramakrishnan, Aarthi, Shen, Li, Szutorisz, Henrietta, Hurd, Yasmin L

“…Cannabis remains one of the most widely abused drugs during pregnancy. In utero exposure to its principal psychoactive component, Δ -tetrahydrocannabinol…”
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Synaptic Zn 2+ potentiates the effects of cocaine on striatal dopamine neurotransmission and behavior by Gomez, Juan L, Bonaventura, Jordi, Keighron, Jacqueline, Wright, Kelsey M, Marable, Dondre L, Rodriguez, Lionel A, Lam, Sherry, Carlton, Meghan L, Ellis, Randall J, Jordan, Chloe J, Bi, Guo-Hua, Solis, Oscar, Pignatelli, Marco, Bannon, Michael J, Xi, Zheng-Xiong, Tanda, Gianluigi, Michaelides, Michael

“…Cocaine binds to the dopamine (DA) transporter (DAT) to regulate cocaine reward and seeking behavior. Zinc (Zn ) also binds to the DAT, but the in vivo…”
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Random feature baselines provide distributional performance and feature selection benchmarks for clinical and 'omic ML by Ellis, Randall J, Airaud, Audrey, Patel, Chirag J

“…Identifying predictive features from high-dimensional datasets is a major task in biomedical research. However, it is difficult to determine the robustness of…”
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