Search Results - "Ellis, Nathan A"

Bloom's Syndrome: Clinical Spectrum, Molecular Pathogenesis, and Cancer Predisposition by Cunniff, Christopher, Bassetti, Jennifer A., Ellis, Nathan A.

“…Bloom's syndrome is an autosomal recessive disorder characterized by prenatal and postnatal growth deficiency, photosensitive skin changes, immune deficiency,…”
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Rescue of collapsed replication forks is dependent on NSMCE2 to prevent mitotic DNA damage by Pond, Kelvin W, de Renty, Christelle, Yagle, Mary K, Ellis, Nathan A

“…NSMCE2 is an E3 SUMO ligase and a subunit of the SMC5/6 complex that associates with the replication fork and protects against genomic instability. Here, we…”
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A meta-analysis of MSI frequency and race in colorectal cancer by Ashktorab, Hassan, Ahuja, Sadhna, Kannan, Lakshmi, Llor, Xavier, Ellis, Nathan A, Xicola, Rosa M, Laiyemo, Adeyinka O, Carethers, John M, Brim, Hassan, Nouraie, Mehdi

“…African Americans (AA) are at a higher risk of colorectal cancer (CRC) and some studies report a higher frequency of microsatellite instability (MSI) in this…”
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SUMO modification regulates BLM and RAD51 interaction at damaged replication forks by Ouyang, Karen J, Woo, Leslie L, Zhu, Jianmei, Huo, Dezheng, Matunis, Michael J, Ellis, Nathan A

“…The gene mutated in Bloom's syndrome, BLM, is important in the repair of damaged replication forks, and it has both pro- and anti-recombinogenic roles in…”
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Extracellular signals induce dynamic ER remodeling through αTAT1-dependent microtubule acetylation by Ortiz, Hannah R., Cruz Flores, Paola, Podgorski, Julia, Ramonett, Aaron, Ahmed, Tasmia, Hempel, Nadine, Charest, Pascale G., Ellis, Nathan A., Langlais, Paul R., Montfort, William R., Mythreye, Karthikeyan, Kumar, Sanjay, Lee, Nam Y.

“…Dynamic changes in the endoplasmic reticulum (ER) morphology are central to maintaining cellular homeostasis. Microtubules (MT) facilitate the continuous…”
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Genome-wide association study provides evidence for a breast cancer risk locus at 6q22.33 by Gold, Bert, Kirchhoff, Tomas, Stefanov, Stefan, Lautenberger, James, Viale, Agnes, Garber, Judy, Friedman, Eitan, Narod, Steven, Olshen, Adam B, Gregersen, Peter, Kosarin, Kristi, Olsh, Adam, Bergeron, Julie, Ellis, Nathan A, Klein, Robert J, Clark, Andrew G, Norton, Larry, Dean, Michael, Boyd, Jeff, Offit, Kenneth

“…We performed a three-phase genome-wide association study (GWAS) using cases and controls from a genetically isolated population, Ashkenazi Jews (AJ), to…”
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βIV-spectrin as a stalk cell-intrinsic regulator of VEGF signaling by Kwak, Eun-A, Pan, Christopher C., Ramonett, Aaron, Kumar, Sanjay, Cruz-Flores, Paola, Ahmed, Tasmia, Ortiz, Hannah R., Lochhead, Jeffrey J., Ellis, Nathan A., Mouneimne, Ghassan, Georgieva, Teodora G., Lee, Yeon Sun, Vanderah, Todd W., Largent-Milnes, Tally, Mohler, Peter J., Hund, Thomas J., Langlais, Paul R., Mythreye, Karthikeyan, Lee, Nam Y.

“…Defective angiogenesis underlies over 50 malignant, ischemic and inflammatory disorders yet long-term therapeutic applications inevitably fail, thus…”
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Is increased colorectal screening effective in preventing distant disease? by Augustus, Gaius Julian, Roe, Denise J, Jacobs, Elizabeth T, Lance, Peter, Ellis, Nathan A

“…Screening in the average risk population for colorectal cancer (CRC) is expected to reduce the incidence of distant (i.e., metastatic) CRCs at least as much as…”
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Live-cell imaging in human colonic monolayers reveals ERK waves limit the stem cell compartment to maintain epithelial homeostasis by Pond, Kelvin W, Morris, Julia M, Alkhimenok, Olga, Varghese, Reeba P, Cabel, Carly R, Ellis, Nathan A, Chakrabarti, Jayati, Zavros, Yana, Merchant, Juanita L, Thorne, Curtis A, Paek, Andrew L

“…The establishment and maintenance of different cellular compartments in tissues is a universal requirement across all metazoans. Maintaining the correct ratio…”
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DNA methylation among firefighters by Zhou, Jin, Jenkins, Timothy G, Jung, Alesia M, Jeong, Kyoung Sook, Zhai, Jing, Jacobs, Elizabeth T, Griffin, Stephanie C, Dearmon-Moore, Devi, Littau, Sally R, Peate, Wayne F, Ellis, Nathan A, Lance, Peter, Chen, Yin, Burgess, Jefferey L

“…Firefighters are exposed to carcinogens and have elevated cancer rates. We hypothesized that occupational exposures in firefighters would lead to DNA…”
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A Protective Role for Arachidonic Acid Metabolites against Advanced Colorectal Adenoma in a Phase III Trial of Selenium by Martinez, Jessica A., Skiba, Meghan B., Chow, H-H. Sherry, Chew, Wade M., Saboda, Kathylynn, Lance, Peter, Ellis, Nathan A., Jacobs, Elizabeth T.

“…Oxylipins derived from arachidonic acid (ARA) have been implicated in the development of colorectal adenomas and colorectal cancer. The primary purpose of this…”
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Small Ubiquitin-related Modifier (SUMO) Binding Determines Substrate Recognition and Paralog-selective SUMO Modification by Zhu, Jianmei, Zhu, Shanshan, Guzzo, Catherine M., Ellis, Nathan A., Sung, Ki Sa, Choi, Cheol Yong, Matunis, Michael J.

“…Small ubiquitin-related modifiers (SUMOs) regulate diverse cellular processes through their covalent attachment to target proteins. Vertebrates express three…”
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Implication of DNA repair genes in Lynch-like syndrome by Xicola, Rosa M., Clark, Julia R., Carroll, Timothy, Alvikas, Jurgis, Marwaha, Priti, Regan, Maureen R., Lopez-Giraldez, Francesc, Choi, Jungmin, Emmadi, Rajyasree, Alagiozian-Angelova, Victoria, Kupfer, Sonia S., Ellis, Nathan A., Llor, Xavier

“…Many colorectal cancers (CRCs) that exhibit microsatellite instability (MSI) are not explained by MLH1 promoter methylation or germline mutations in mismatch…”
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Heterozygous mutations in DNA repair genes and hereditary breast cancer: a question of power by Ellis, Nathan A, Offit, Kenneth

“…After filtering out the overtly deleterious mutations that are polymorphic in the human population (under the assumption that the risk-causing variation in…”
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Single nucleotide polymorphisms in the MYLKP1 pseudogene are associated with increased colon cancer risk in African Americans by Lynn, Heather, Sun, Xiaoguang, Ayshiev, Djanybek, Siegler, Jessica H, Rizzo, Alicia N, Karnes, Jason H, Gonzales Garay, Manuel, Wang, Ting, Casanova, Nancy, Camp, Sara M, Ellis, Nathan A, Garcia, Joe G N

“…Pseudogenes are paralogues of functional genes historically viewed as defunct due to either the lack of regulatory elements or the presence of frameshift…”
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BLM Sumoylation Is Required for Replication Stability and Normal Fork Velocity During DNA Replication by de Renty, Christelle, Pond, Kelvin W, Yagle, Mary K, Ellis, Nathan A

“…BLM is sumoylated in response to replication stress. We have studied the role of BLM sumoylation in physiologically normal and replication-stressed conditions…”
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Clear cell renal cell carcinoma molecular variations in non‐Hispanic White and Hispanic patients by Batai, Ken, Chen, Yuliang, Rheinheimer, Brenna A., Arora, Amit, Pandey, Ritu, Heimark, Ronald L., Bracamonte, Erika R., Ellis, Nathan A., Lee, Benjamin R.

“…Background The United States is becoming increasingly diverse, but few molecular studies have assessed the progression of clear cell renal cell carcinoma…”
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Genetic Heterogeneity in Colorectal Cancer Associations Between African and European Americans by Kupfer, Sonia S, Anderson, Jeffrey R, Hooker, Stanley, Skol, Andrew, Kittles, Rick A, Keku, Temitope O, Sandler, Robert S, Ellis, Nathan A

“…Background & Aims Genome-wide association studies of colorectal cancer (CRC) have identified risk variants in 10 genomic regions. None of these studies…”
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Colorectal Cancer Disparity in African Americans: Risk Factors and Carcinogenic Mechanisms by Augustus, Gaius J, Ellis, Nathan A

“…African Americans have the highest incidence and mortality rates of colorectal cancer (CRC) of any ethnic group in the United States. Although some of these…”
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Linkage of NAMPT promoter variants to eNAMPT secretion, plasma eNAMPT levels, and ARDS severity by Lynn, Heather, Sun, Xiaoguang, Casanova, Nancy G., Bime, Christian, Reyes Hernon, Vivian, Lanham, Clayton, Oita, Radu C., Ramos, Nikolas, Sun, Belinda, Coletta, Dawn K., Camp, Sara M., Karnes, Jason H., Ellis, Nathan A., Garcia, Joe G.N.

“…Background and objectives: eNAMPT (extracellular nicotinamide phosphoribosyltransferase), a novel DAMP and TLR4 ligand, is a druggable ARDS therapeutic target…”
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