Search Results - "Ellis, L. L."
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Sirtuin activators and inhibitors: Promises, achievements, and challenges
Published in Pharmacology & therapeutics (Oxford) (01-08-2018)“…The NAD+-dependent protein lysine deacylases of the Sirtuin family regulate various physiological functions, from energy metabolism to stress responses. The…”
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Three-Dimensional Self-Supported Metal Oxides for Advanced Energy Storage
Published in Advanced materials (Weinheim) (04-06-2014)“…The miniaturization of power sources aimed at integration into micro‐ and nano‐electronic devices is a big challenge. To ensure the future development of fully…”
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3
The structure of a T-cell mechanosensor
Published in Nature (London) (01-09-2019)“…T-cell receptors orchestrate immune-system responses against infection and cancer. A structure of an entire T-cell receptor complex clarifies its assembly and…”
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COVID-19 and business renewal: Lessons and insights from the global airline industry
Published in International Business Review (Oxford, England) (01-06-2021)“…•The COVID-19 pandemic and business renewal are explored.•Lessons from history for business renewal is offered.•The article offers a four-stage approach…”
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αβ T Cell Receptor Mechanosensing Forces out Serial Engagement
Published in Trends in immunology (01-08-2018)“…T lymphocytes use αβ T cell receptors (TCRs) to recognize sparse antigenic peptides bound to MHC molecules (pMHCs) arrayed on antigen-presenting cells (APCs)…”
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Transdisciplinary perspective on sustainable multi-tier supply chains: a triple bottom line inspired framework and future research directions
Published in International journal of production research (18-07-2023)“…Global sourcing and increased interdependencies between organisations have created more complex multi-tier supply chains. While these supply chains have been…”
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Heart failure: when form fails to follow function
Published in European heart journal (01-02-2016)“…Cardiac performance is normally determined by architectural, cellular, and molecular structures that determine the heart's form, and by physiological and…”
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Evolution of homologous recombination rates across bacteria
Published in Proceedings of the National Academy of Sciences - PNAS (30-04-2024)“…Bacteria are nonsexual organisms but are capable of exchanging DNA at diverse degrees through homologous recombination. Intriguingly, the rates of…”
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Mechanosensing drives acuity of αβ T-cell recognition
Published in Proceedings of the National Academy of Sciences - PNAS (26-09-2017)“…T lymphocytes use surface αβ T-cell receptors (TCRs) to recognize peptides bound to MHC molecules (pMHCs) on antigen-presenting cells (APCs). How the exquisite…”
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The αβTCR mechanosensor exploits dynamic ectodomain allostery to optimize its ligand recognition site
Published in Proceedings of the National Academy of Sciences - PNAS (01-09-2020)“…Each αβT cell receptor (TCR) functions as a mechanosensor. The TCR is comprised of a clonotypic TCRαβ ligand-binding heterodimer and the noncovalently…”
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Harnessing αβ T cell receptor mechanobiology to achieve the promise of immuno-oncology
Published in Proceedings of the National Academy of Sciences - PNAS (04-07-2023)“…T cell receptors (TCR) on cytolytic T lymphocytes (CTLs) recognize "foreign" antigens bound in the groove of major histocompatibility complex (MHC) molecules…”
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Factors influencing technology and knowledge transfer: Configurational recipes for Sub-Saharan Africa
Published in Journal of business research (01-11-2016)“…General studies on technology and knowledge (T&K) transfer to developing countries have often adopted methods that yield inconsistent results. Traditional…”
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Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime
Published in Proceedings of the National Academy of Sciences - PNAS (03-02-2015)“…Significance The αβ T-cell receptor (TCR) on mammalian T lymphocytes recognizes intracellular pathogens to afford protective immunity. Detection of various…”
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14
Controlling the polarization and vortex charge of attosecond high-harmonic beams via simultaneous spin–orbit momentum conservation
Published in Nature photonics (01-02-2019)“…Optical interactions are governed by both spin and angular momentum conservation laws, which serve as a tool for controlling light–matter interactions or…”
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Gene flow and introgression are pervasive forces shaping the evolution of bacterial species
Published in Genome Biology (10-11-2022)“…Although originally thought to evolve clonally, studies have revealed that most bacteria exchange DNA. However, it remains unclear to what extent gene flow…”
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Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination
Published in The Journal of immunology (1950) (15-11-2016)“…Germinal centers (GCs) are anatomic sites where B cells undergo secondary diversification to produce high-affinity, class-switched Abs. We hypothesized that…”
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Value of Measuring Lipoprotein(a) During Cascade Testing for Familial Hypercholesterolemia
Published in Journal of the American College of Cardiology (12-03-2019)“…Familial hypercholesterolemia (FH) and elevated lipoprotein(a) [Lp(a)] are inherited disorders associated with premature atherosclerotic cardiovascular disease…”
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A multifunctional 3.5 V iron-based phosphate cathode for rechargeable batteries
Published in Nature materials (01-10-2007)“…In the search for new positive-electrode materials for lithium-ion batteries, recent research has focused on nanostructured lithium transition-metal phosphates…”
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Ligand-dependent conformational dynamics of MPER-binding HIV-1 antibody Fab235
Published in Biophysical journal (10-02-2023)Get full text
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Paediatric gastroenterology evaluation of overweight and obese children referred from primary care for suspected non‐alcoholic fatty liver disease
Published in Alimentary pharmacology & therapeutics (01-11-2013)“…Summary Background Screening overweight and obese children for non‐alcoholic fatty liver disease (NAFLD) is recommended by paediatric and endocrinology…”
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