Search Results - "Ellis, Justin J"

Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias by Walker, Christopher J., Oaks, Joshua J., Santhanam, Ramasamy, Neviani, Paolo, Harb, Jason G., Ferenchak, Gregory, Ellis, Justin J., Landesman, Yosef, Eisfeld, Ann-Kathrin, Gabrail, Nash Y., Smith, Carrie L., Caligiuri, Michael A., Hokland, Peter, Roy, Denis Claude, Reid, Alistair, Milojkovic, Dragana, Goldman, John M., Apperley, Jane, Garzon, Ramiro, Marcucci, Guido, Shacham, Sharon, Kauffman, Michael G., Perrotti, Danilo

“…As tyrosine kinase inhibitors (TKIs) fail to induce long-term response in blast crisis chronic myelogenous leukemia (CML-BC) and Philadelphia…”
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PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells by Neviani, Paolo, Harb, Jason G, Oaks, Joshua J, Santhanam, Ramasamy, Walker, Christopher J, Ellis, Justin J, Ferenchak, Gregory, Dorrance, Adrienne M, Paisie, Carolyn A, Eiring, Anna M, Ma, Yihui, Mao, Hsiaoyin C, Zhang, Bin, Wunderlich, Mark, May, Philippa C, Sun, Chaode, Saddoughi, Sahar A, Bielawski, Jacek, Blum, William, Klisovic, Rebecca B, Solt, Janelle A, Byrd, John C, Volinia, Stefano, Cortes, Jorge, Huettner, Claudia S, Koschmieder, Steffen, Holyoake, Tessa L, Devine, Steven, Caligiuri, Michael A, Croce, Carlo M, Garzon, Ramiro, Ogretmen, Besim, Arlinghaus, Ralph B, Chen, Ching-Shih, Bittman, Robert, Hokland, Peter, Roy, Denis-Claude, Milojkovic, Dragana, Apperley, Jane, Goldman, John M, Reid, Alistair, Mulloy, James C, Bhatia, Ravi, Marcucci, Guido, Perrotti, Danilo

“…The success of tyrosine kinase inhibitors (TKIs) in treating chronic myeloid leukemia (CML) depends on the requirement for BCR-ABL1 kinase activity in CML…”
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Persistence of Drug-Resistant Leukemic Stem Cells and Impaired NK Cell Immunity in CML Patients Depend on MIR300 Antiproliferative and PP2A-Activating Functions by Silvestri, Giovannino, Trotta, Rossana, Stramucci, Lorenzo, Ellis, Justin J, Harb, Jason G, Neviani, Paolo, Wang, Shuzhen, Eisfeld, Ann-Kathrin, Walker, Christopher J, Zhang, Bin, Srutova, Klara, Gambacorti-Passerini, Carlo, Pineda, Gabriel, Jamieson, Catriona H M, Stagno, Fabio, Vigneri, Paolo, Nteliopoulos, Georgios, May, Philippa C, Reid, Alistair G, Garzon, Ramiro, Roy, Denis-Claude, Moutuou, Moutuaata M, Guimond, Martin, Hokland, Peter, Deininger, Michael W, Fitzgerald, Garrett, Harman, Christopher, Dazzi, Francesco, Milojkovic, Dragana, Apperley, Jane F, Marcucci, Guido, Qi, Jianfei, Polakova, Katerina Machova, Zou, Ying, Fan, Xiaoxuan, Baer, Maria R, Calabretta, Bruno, Perrotti, Danilo

“…Persistence of drug-resistant quiescent leukemic stem cells (LSC) and impaired natural killer (NK) cell immune response account for relapse of chronic…”
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Persistence of Drug-Resistant Leukemic Stem Cells and Impaired NK Cell Immunity in CML Patients Depend on MIR300 Antiproliferative and PP2A-Activating Functions by Silvestri, Giovannino, Trotta, Rossana, Stramucci, Lorenzo, Ellis, Justin J., Harb, Jason G., Neviani, Paolo, Wang, Shuzhen, Eisfeld, Ann-Kathrin, Walker, Christopher J., Zhang, Bin, Srutova, Klara, Gambacorti-Passerini, Carlo, Pineda, Gabriel, Jamieson, Catriona H. M., Stagno, Fabio, Vigneri, Paolo, Nteliopoulos, Georgios, May, Philippa C., Reid, Alistair G., Garzon, Ramiro, Roy, Denis-Claude, Moutuou, Moutuaata M., Guimond, Martin, Hokland, Peter, Deininger, Michael W., Fitzgerald, Garrett, Harman, Christopher, Dazzi, Francesco, Milojkovic, Dragana, Apperley, Jane F., Marcucci, Guido, Qi, Jianfei, Polakova, Katerina Machova, Zou, Ying, Fan, Xiaoxuan, Baer, Maria R., Calabretta, Bruno, Perrotti, Danilo

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Abstract 951: Role of the MSC-derived exosomal and endogenous JAK2-SET/PP2A-β-catenin-modulator miR-300 in leukemic stem/progenitor proliferation and survival in CML by Trotta, Rossana, Silvestri, Giovannino, Stramucci, Lorenzo, Ellis, Justin J., Yu, Justine, Harb, Jason J., Neviani, Paolo, Marcucci, Guido, Srutova, Klara, Machova, Polakova K., Roy, Denis-Claude, Hokland, Peter, Deininger, Michael, Bhatia, Ravi, Gambacorti-Passerini, Carlo, Milojkovic, Dragana, Reid, Alistair, Apperley, Jane, Livak, Ferenc, Qi, Jianfei, Baer, Maria R., Perrotti, Danilo

“…Abstract MiR-300 is a microRNA predicted to target multiple components of the BCR-ABL1/JAK2/hnRNPA1/SET/PP2A/β-catenin pathway, which is essential for…”
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