Search Results - "Ellis, Jessica M."

Adipose Fatty Acid Oxidation Is Required for Thermogenesis and Potentiates Oxidative Stress-Induced Inflammation by Lee, Jieun, Ellis, Jessica M., Wolfgang, Michael J.

“…To understand the contribution of adipose tissue fatty acid oxidation to whole-body metabolism, we generated mice with an adipose-specific knockout of…”
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The role of ethanolamine phosphate phospholyase in regulation of astrocyte lipid homeostasis by White, Cory J., Ellis, Jessica M., Wolfgang, Michael J.

“…Dietary lipid composition has been shown to impact brain morphology, brain development, and neurologic function. However, how diet uniquely regulates brain…”
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Metabolic and tissue-specific regulation of acyl-CoA metabolism by Ellis, Jessica M, Bowman, Caitlyn E, Wolfgang, Michael J

“…Acyl-CoA formation initiates cellular fatty acid metabolism. Acyl-CoAs are generated by the ligation of a fatty acid to Coenzyme A mediated by a large family…”
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Acyl-CoA synthetase 6 enriches the neuroprotective omega-3 fatty acid DHA in the brain by Fernandez, Regina F., Kim, Sora Q., Zhao, Yingwei, Foguth, Rachel M., Weera, Marcus M., Counihan, Jessica L., Nomura, Daniel K., Chester, Julia A., Cannon, Jason R., Ellis, Jessica M.

“…Docosahexaenoic acid (DHA) is an omega-3 fatty acid that is highly abundant in the brain and confers protection against numerous neurological diseases, yet the…”
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Skeletal muscle undergoes fiber type metabolic switch without myosin heavy chain switch in response to defective fatty acid oxidation by Pereyra, Andrea S., Lin, Chien-Te, Sanchez, Daniela Mesa, Laskin, Julia, Spangenburg, Espen E., Neufer, P. Darrell, Fisher–Wellman, Kelsey, Ellis, Jessica M.

“…Skeletal muscle is a heterogeneous and dynamic tissue that adapts to functional demands and substrate availability by modulating muscle fiber size and type…”
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Acyl Coenzyme A Thioesterase 7 Regulates Neuronal Fatty Acid Metabolism To Prevent Neurotoxicity by Ellis, Jessica M., Wong, G. William, Wolfgang, Michael J.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Octanoate is differentially metabolized in liver and muscle and fails to rescue cardiomyopathy in CPT2 deficiency by Pereyra, Andrea S., Harris, Kate L., Soepriatna, Arvin H., Waterbury, Quin A., Bharathi, Sivakama S., Zhang, Yuxun, Fisher-Wellman, Kelsey H., Goergen, Craig J., Goetzman, Eric S., Ellis, Jessica M.

“…Long-chain fatty acid oxidation is frequently impaired in primary and systemic metabolic diseases affecting the heart; thus, therapeutically increasing…”
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Mouse Cardiac Acyl Coenzyme A Synthetase 1 Deficiency Impairs Fatty Acid Oxidation and Induces Cardiac Hypertrophy by Ellis, Jessica M., Mentock, Shannon M., DePetrillo, Michael A., Koves, Timothy R., Sen, Shiraj, Watkins, Steven M., Muoio, Deborah M., Cline, Gary W., Taegtmeyer, Heinrich, Shulman, Gerald I., Willis, Monte S., Coleman, Rosalind A.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Loss of long‐chain acyl‐CoA synthetase isoform 1 impairs cardiac autophagy and mitochondrial structure through mechanistic target of rapamycin complex 1 activation by Grevengoed, Trisha J., Cooper, Daniel E., Young, Pamela A., Ellis, Jessica M., Coleman, Rosalind A.

“…ABSTRACT Because hearts with a temporally induced knockout of acyl‐CoA synthetase 1 (Acsl1T‐/‐) are virtually unable to oxidize fatty acids, glucose use…”
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Loss of mitochondria long-chain fatty acid oxidation impairs skeletal muscle contractility by disrupting myofibril structure and calcium homeostasis by Pereyra, Andrea S., Fernandez, Regina F., Amorese, Adam, Castro, Jasmine N., Lin, Chien-Te, Spangenburg, Espen E., Ellis, Jessica M.

“…Abnormal lipid metabolism in mammalian tissues can be highly deleterious, leading to organ failure. Carnitine Palmitoyltransferase 2 (CPT2) deficiency is an…”
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Pan-tissue mitochondrial phenotyping reveals lower OXPHOS expression and function across cancer types by Boykov, Ilya N., Montgomery, McLane M., Hagen, James T., Aruleba, Raphael T., McLaughlin, Kelsey L., Coalson, Hannah S., Nelson, Margaret A., Pereyra, Andrea S., Ellis, Jessica M., Zeczycki, Tonya N., Vohra, Nasreen A., Tan, Su-Fern, Cabot, Myles C., Fisher-Wellman, Kelsey H.

“…Targeting mitochondrial oxidative phosphorylation (OXPHOS) to treat cancer has been hampered due to serious side-effects potentially arising from the inability…”
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Loss of ACOT7 potentiates seizures and metabolic dysfunction by Bowman, Caitlyn E, Selen Alpergin, Ebru S, Ellis, Jessica M, Wolfgang, Michael J

“…Neurons uniquely antagonize fatty acid utilization by hydrolyzing the activated form of fatty acids, long chain acyl-CoAs, via the enzyme acyl-CoA thioesterase…”
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Tissue-specific characterization of mitochondrial branched-chain keto acid oxidation using a multiplexed assay platform by Goldberg, Emma J, Buddo, Katherine A, McLaughlin, Kelsey L, Fernandez, Regina F, Pereyra, Andrea S, Psaltis, Christine E, Lin, Chien-Te, Hagen, James T, Boykov, Ilya N, Nguyen, Tiffany K, Gowdy, Kymberly M, Ellis, Jessica M, Neufer, P Darrell, McClung, Joseph M, Fisher-Wellman, Kelsey H

“…Alterations to branched-chain keto acid (BCKA) oxidation have been implicated in a wide variety of human diseases, ranging from diabetes to cancer. Although…”
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Inflammatory stimuli induce acyl-CoA thioesterase 7 and remodeling of phospholipids containing unsaturated long (≥C20)-acyl chains in macrophages[S] by Wall, Valerie Z., Barnhart, Shelley, Kramer, Farah, Kanter, Jenny E., Vivekanandan-Giri, Anuradha, Pennathur, Subramaniam, Bolego, Chiara, Ellis, Jessica M., Gijón, Miguel A., Wolfgang, Michael J., Bornfeldt, Karin E.

“…Acyl-CoA thioesterase 7 (ACOT7) is an intracellular enzyme that converts acyl-CoAs to FFAs. ACOT7 is induced by lipopolysaccharide (LPS); thus, we investigated…”
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Interruption of Ganglioside Synthesis Produces Central Nervous System Degeneration and Altered Axon-Glial Interactions by Yamashita, Tadashi, Wu, Yun-Ping, Sandhoff, Roger, Werth, Norbert, Mizukami, Hiroki, Ellis, Jessica M., Dupree, Jeffrey L., Geyer, Rudolf, Sandhoff, Konrad, Proia, Richard L., Brady, Roscoe O.

“…Gangliosides, which are sialylated glycosphingolipids, are the major class of glycoconjugates on neurons and carry the majority of the sialic acid within the…”
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Acyl-CoA synthetase 6 controls rod photoreceptor function and survival by shaping the phospholipid composition of retinal membranes by Wang, Yixiao, Becker, Silke, Finkelstein, Stella, Dyka, Frank M., Liu, Haitao, Eminhizer, Mark, Hao, Ying, Brush, Richard S., Spencer, William J., Arshavsky, Vadim Y., Ash, John D., Du, Jianhai, Agbaga, Martin-Paul, Vinberg, Frans, Ellis, Jessica M., Lobanova, Ekaterina S.

“…The retina is light-sensitive neuronal tissue in the back of the eye. The phospholipid composition of the retina is unique and highly enriched in…”
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Acyl-CoA synthetase 6 is required for brain docosahexaenoic acid retention and neuroprotection during aging by Fernandez, Regina F, Pereyra, Andrea S, Diaz, Victoria, Wilson, Emily S, Litwa, Karen A, Martínez-Gardeazabal, Jonatan, Jackson, Shelley N, Brenna, J Thomas, Hermann, Brian P, Eells, Jeffrey B, Ellis, Jessica M

“…The omega-3 fatty acid docosahexaenoic acid (DHA) inversely relates to neurological impairments with aging; however, limited nondietary models manipulating…”
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Neutral Ceramidase Encoded by the Asah2 Gene Is Essential for the Intestinal Degradation of Sphingolipids by Kono, Mari, Dreier, Jennifer L., Ellis, Jessica M., Allende, Maria L., Kalkofen, Danielle N., Sanders, Kathleen M., Bielawski, Jacek, Bielawska, Alicja, Hannun, Yusuf A., Proia, Richard L.

“…Complex sphingolipids are abundant as eukaryotic cell membrane components, whereas their metabolites, in particular ceramide, sphingosine, and sphingosine…”
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Cardiac energy dependence on glucose increases metabolites related to glutathione and activates metabolic genes controlled by mechanistic target of rapamycin by Schisler, Jonathan C, Grevengoed, Trisha J, Pascual, Florencia, Cooper, Daniel E, Ellis, Jessica M, Paul, David S, Willis, Monte S, Patterson, Cam, Jia, Wei, Coleman, Rosalind A

“…Long chain acyl-CoA synthetases (ACSL) catalyze long-chain fatty acids (FA) conversion to acyl-CoAs. Temporal ACSL1 inactivation in mouse hearts (Acsl1(H-/-))…”
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Acyl-CoA synthetases as regulators of brain phospholipid acyl-chain diversity by Fernandez, Regina F., Ellis, Jessica M

“…•Phospholipid acyl-chain composition is highly diverse across tissues and cell-types.•Membrane phospholipid acyl-chain composition affects cellular biological…”
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