Search Results - "Ellis, IO"

Genomic and immunophenotypical characterization of pure micropapillary carcinomas of the breast by Marchiò, C, Iravani, M, Natrajan, R, Lambros, MB, Savage, K, Tamber, N, Fenwick, K, Mackay, A, Senetta, R, Palma, S. Di, Schmitt, FC, Bussolati, G, Ellis, IO, Ashworth, A, Sapino, A, Reis-Filho, JS

“…Pure invasive micropapillary carcinoma (MPC) is a special histological type that accounts for 0.7-3% of all breast cancers. MPC has a distinctive growth…”
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Abstract P3-11-08: Sperm associated antigen 5 (SPAG5) predicts pathological complete response (pCR) and distant relapse risk to HER2 targeting agents and anthracycline based chemotherapy in HER2 positive (HER2+) breast cancer (BC) by Abdel-Fatah, TM, Ball, GR, Ellis, IO, Chan, A, Chan, SY

“…Abstract Background: Previously we found that SPAG5 gene was amplified/gained in 20-35% of HER2+BC. Herein, we investigated the prognostic and predictive…”
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Early-onset breast cancer - histopathological and prognostic considerations by KOLLIAS, J, ELSTON, C. W, ELLIS, I. O, ROBERTSON, J. F. R, BLAMEY, R. W

“…Young age at diagnosis is claimed to be a prognostic factor in the natural history of breast cancer. Of 2879 patients aged < 70 years treated for primary…”
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Which lesions with a radiological or core biopsy diagnosis of fibroadenoma should be excised? by Lee, Ahs, James, J, Whisker, L, Rakha, E A, Ellis, I O

“…A recent Association of Breast Surgery summary statement on fibroadenoma management recommends excision only for cellular fibroepithelial lesions and rapidly…”
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High‐throughput protein expression analysis using tissue microarray technology of a large well‐characterised series identifies biologically distinct classes of breast cancer confirming recent cDNA expression analyses by Abd El‐Rehim, Dalia M., Ball, Graham, Pinder, Sarah E., Rakha, Emad, Paish, Claire, Robertson, John F.R., Macmillan, Douglas, Blamey, Roger W., Ellis, Ian O.

“…Recent studies on gene molecular profiling using cDNA microarray in a relatively small series of breast cancer have identified biologically distinct groups…”
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Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer by Rakha, Emad A, Boyce, Richard W G, Abd El-Rehim, Dalia, Kurien, Thomas, Green, Andrew R, Paish, Emma C, Robertson, John F R, Ellis, Ian O

“…Mucins are a large family of glycoproteins expressed by many epithelial cells and their malignant counterparts. Much interest has been focused on expression of…”
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Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis by Watson, Nicholas F.S., Ramage, Judith M., Madjd, Zahra, Spendlove, Ian, Ellis, Ian O., Scholefield, John H., Durrant, Lindy G.

“…Many colorectal tumors lose or downregulate cell surface expression of MHC class I molecules conferring resistance to T‐cell‐mediated attack. It has been…”
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Expression of luminal and basal cytokeratins in human breast carcinoma by Abd El-Rehim, Dalia M, Pinder, Sarah E, Paish, Claire E, Bell, J, Blamey, RW, Robertson, John FR, Nicholson, Robert I, Ellis, Ian O

“…We have examined basal and luminal cell cytokeratin expression in 1944 cases of invasive breast carcinoma, using tissue microarray (TMA) technology, to…”
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Morphological and immunophenotypic analysis of breast carcinomas with basal and myoepithelial differentiation by Rakha, EA, Putti, TC, Abd El-Rehim, DM, Paish, C, Green, AR, Powe, DG, Lee, AH, Robertson, JF, Ellis, IO

“…The aim of this study was to assess the morphological characteristics and immunohistochemical profile of breast carcinomas with basal and myoepithelial…”
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Expression of ras p21, p53 and c-erbB-2 in advanced breast cancer and response to first line hormonal therapy by ARCHER, S. G, ELIOPOULOS, A, SPANDIDOS, D, BARNES, D, ELLIS, I. O, BLAMEY, R. W, NICHOLSON, R. I, ROBERTSON, J. F. R

“…Several oncogenes and tumour-suppressor genes have been identified that may have an important role in the development of human breast carcinoma. Furthermore,…”
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Bcl-2 Is a Prognostic Marker in Breast Cancer Independently of the Nottingham Prognostic Index by CALLAGY, Grace M, PHAROAH, Paul D, FINDER, Sarah E, HSU, Forrest D, NIELSEN, Torsten O, RAGAZ, Joseph, ELLIS, Ian O, HUNTSMAN, David, CALDAS, Carlos

“…Purpose: Prognostication of breast cancer using clinicopathologic variables, although useful, remains imperfect. Many reports suggest that gene expression…”
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Columnar cell lesions of the breast: The missing link in breast cancer progression? : A morphological and molecular analysis by SIMPSON, Peter T, GALE, Theo, ELLIS, Ian O, LAKHANI, Sunil R, REIS-FILHO, Jorge S, JONES, Chris, PARRY, Suzanne, SLOANE, John P, HANBY, Andrew, PINDER, Sarah E, LEE, Andrew H. S, HUMPHREYS, Steve

“…Columnar cell lesions (CCLs) of the breast are a spectrum of lesions that have posed difficulties to pathologists for many years, prompting discussion…”
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Estrogen receptor-negative breast carcinomas: a review of morphology and immunophenotypical analysis by Putti, Thomas C, El-Rehim, Dalia M Abd, Rakha, Emad A, Paish, Claire E, Lee, Andrew HS, Pinder, Sarah E, Ellis, Ian O

“…Estrogen receptor (ER)-negative breast cancers are a group of tumors with poor prognosis and fewer cancer prevention and treatment strategies compared to…”
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Abstract P5-08-17: A study of c-Jun N-terminal kinase (JNK) and c-Jun as biomarkers in early breast cancer by Palmieri, C, Rudraraju, B, Giannoudis, A, Moore, D, Shaw, J, Chan, S, Ellis, IO, Caldas, C, Coombes, RC, Carroll, JS, Ali, S, Abdel-Fatah, TMA

“…Abstract Background The AP-1 transcription factor c-Jun is a key downstream target of c-Jun N-terminal kinase (JNK) which mediates intracellular signalling…”
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Total loss of MHC class I is an independent indicator of good prognosis in breast cancer by Madjd, Zahra, Spendlove, Ian, Pinder, Sarah E., Ellis, Ian O., Durrant, Lindy G.

“…Tumours can be recognised by CTL and NK cells. CTL recognition depends on expression of MHC Class I loaded with peptides from tumour antigens. In contrast,…”
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Abstract P6-09-16: Identification of proliferation related derivers and their roles in precision medicine for breast cancers: A retrospective multidimensional comparative, integrated genomic, transcriptomic, and protein analysis by Abdel-Fatah, TMA, Agarwal, D, Zafeiris, D, Pongor, L, Györffy, B, Rueda, OM, Moseley, PM, Green, AR, Liu, D-X, Pockley, AG, Rees, RC, Caldas, C, Ellis, IO, Ball, GR, Chan, SYT

“…Abstract Backgound and Aim: The best test to guide the choice of systemic therapy for breast cancer (BC) has not yet been identified. We did this study to…”
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Epidermal growth factor receptor/HER2/insulin-like growth factor receptor signalling and oestrogen receptor activity in clinical breast cancer by Gee, J M, Robertson, J F, Gutteridge, E, Ellis, I O, Pinder, S E, Rubini, M, Nicholson, R I

“…Breast cancer models of acquired tamoxifen resistance, oestrogen receptor (ER)+ /ER− de novo resistance and gene transfer studies cumulatively demonstrate the…”
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Abstract PD4-13: Estrogen receptor-negative breast adenomyoepitheliomas are driven by co-occurring HRAS hotspot and PI3K pathway gene mutations: A genetic and functional analysis by Geyer, FC, Li, A, Papanastasiou, AD, Smith, A, Selenica, P, Burke, KA, Edelweiss, M, Wen, H-C, Piscuoglio, S, Schultheis, AM, Martelotto, LG, Pareja, F, Kumar, R, Brandes, A, Lozada, J, Macedo, GS, Muenst, S, Terracciano, LM, Jungbluth, A, Foschini, MP, Wen, HY, Brogi, E, Palazzo, J, Rubin, BP, Ng, CKY, Norton, L, Varga, Z, Ellis, IO, Rakha, E, Chandarlapatty, S, Weigelt, B, Reis-Filho, JS

“…Abstract Introduction:Adenomyoepithelioma (AME) of the breast is a rare biphasic tumor, characterized by epithelial and myoepithelial differentiation. Although…”
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C-erbB-3 in human breast carcinoma: expression and relation to prognosis and established prognostic indicators by Travis, A, Pinder, S E, Robertson, J F, Bell, J A, Wencyk, P, Gullick, W J, Nicholson, R I, Poller, D N, Blamey, R W, Elston, C W, Ellis, I O

“…A series of 346 patients with primary operable breast cancer and a series of 145 patients with advanced breast cancer were investigated for c-erbB-3 protein…”
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Expression and co-expression of the members of the epidermal growth factor receptor (EGFR) family in invasive breast carcinoma by ABD EL-REHIM, D. M, PINDER, S. E, PAISH, C. E, BELL, J. A, RAMPAUL, R. S, BLAMEY, R. W, ROBERTSON, J. F. R, NICHOLSON, R. I, ELLIS, I. O

“…The epidermal growth factor receptor (EGFR) family plays an important role in breast carcinogenesis. Much interest has been focused recently on its members…”
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