Search Results - "Ellis, Earl F."

Activation of Extracellular Signal-Regulated Kinase by Stretch-Induced Injury in Astrocytes Involves Extracellular ATP and P2 Purinergic Receptors by Neary, Joseph T, Kang, Yuan, Willoughby, Karen A, Ellis, Earl F

“…Gliosis is characterized by hypertrophic and hyperplastic responses of astrocytes to brain injury. To determine whether injury of astrocytes produced by an in…”
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Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock by WAGNER, J. A, VARGA, K, ELLIS, E. F, RZIGALINSKI, B. A, MARTIN, B. R, KUNOS, G

“…Anandamide, an endogenous cannabinoid ligand, binds to CB1 cannabinoid receptors in the brain and mimics the neurobehavioural actions of marijuana…”
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Antagonism of group I metabotropic glutamate receptors and PLC attenuates increases in inositol trisphosphate and reduces reactive gliosis in strain-injured astrocytes by Floyd, Candace L, Rzigalinski, Beverly A, Sitterding, Heather A, Willoughby, Karen A, Ellis, Earl F

“…We have previously found that in vitro traumatic injury uncouples IP3-mediated intracellular free calcium ([Ca2+]i) signaling in astrocytes (Rzigalinski et…”
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S100B protein is released from rat neonatal neurons, astrocytes, and microglia by in vitro trauma and anti-S100 increases trauma-induced delayed neuronal injury and negates the protective effect of exogenous S100B on neurons by Ellis, Earl F, Willoughby, Karen A, Sparks, Sallie A, Chen, Tao

“…S100B protein is found in brain, has been used as a marker for brain injury and is neurotrophic. Using a well-characterized in vitro model of brain cell…”
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S100B protein is released by in vitro trauma and reduces delayed neuronal injury by Willoughby, Karen A., Kleindienst, Andrea, Müller, Christian, Chen, Tao, Muir, Judith K., Ellis, Earl F.

“…S100B protein in brain is produced primarily by astrocytes, has been used as a marker for brain injury and has also been shown to be neurotrophic and…”
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Traumatic Injury of Cortical Neurons Causes Changes in Intracellular Calcium Stores and Capacitative Calcium Influx by Weber, John T., Rzigalinski, Beverly A., Ellis, Earl F.

“…Using an in vitro traumatic injury model, we examined the effects of mechanical (stretch) injury on intracellular Ca2+ store-mediated signaling in cultured…”
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Enhancement of AMPA-Mediated Current after Traumatic Injury in Cortical Neurons by Goforth, Paulette B, Ellis, Earl F, Satin, Leslie S

“…Overactivation of ionotropic glutamate receptors has been implicated in the pathophysiology of traumatic brain injury. Using an in vitro cell injury model, we…”
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Reduction of voltage-dependent Mg2+ blockade of NMDA current in mechanically injured neurons by ZHANG, L, RZIGALINSKI, B. A, ELLIS, E. F, SATIN, L. S

“…Activation of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptors is implicated in the pathophysiology of traumatic brain injury. Here, the effects…”
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Mechanical injury modulates AMPA receptor kinetics via an NMDA receptor-dependent pathway by Goforth, Paulette B, Ellis, Earl F, Satin, Leslie S

“…Alterations in glutamatergic transmission are thought to contribute to secondary neuronal damage following traumatic brain injury. Using an in vitro cell…”
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Potentiation of GABA(A) currents after mechanical injury of cortical neurons by Kao, Chang-Qing, Goforth, Paulette B, Ellis, Earl F, Satin, Leslie S

“…Numerous studies have implicated glutamate receptors, glutamate neurotoxicity, and hyperexcitation in the pathobiology of traumatic brain injury, yet much less…”
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Calcium Influx Factor, Further Evidence It Is 5,6-Epoxyeicosatrienoic Acid by Rzigalinski, Beverly A., Willoughby, Karen A., Hoffman, Stuart W., Falck, J.R., Ellis, Earl F.

“…We present evidence in astrocytes that 5,6-epoxyeicosatrienoic acid, a cytochrome P450 epoxygenase metabolite of arachidonic acid, may be a component of…”
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The biodisposition and metabolism of anandamide in mice by Willoughby, K A, Moore, S F, Martin, B R, Ellis, E F

“…The endogenous cannabinoid anandamide (AN) has been reported to produce pharmacological effects similar to those of delta9-tetrahydrocannabinol but with a…”
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Isoprostanes: free radical-generated prostaglandins with constrictor effects on cerebral arterioles by Hoffman, S W, Moore, S, Ellis, E F

“…Isoprostanes are generated by cyclooxygenase-independent free radical attack of arachidonic acid and are potent constrictors of the peripheral vasculature…”
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Group I metabotropic receptor antagonism blocks depletion of calcium stores and reduces potentiated capacitative calcium entry in strain-injured neurons and astrocytes by Chen, Tao, Willoughby, Karen A, Ellis, Earl F

“…Antagonism of the group I metabotropic receptor subtype 1 (mGluR1) with (RS)-1-aminoindan-1,5-dicarboxylic acid (AIDA) has been shown to reduce deficits after…”
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NMDA receptor activation contributes to a portion of the decreased mitochondrial membrane potential and elevated intracellular free calcium in strain-injured neurons by Ahmed, Syed M, Weber, John T, Liang, Shi, Willoughby, Karen A, Sitterding, Heather A, Rzigalinski, Beverly A, Ellis, Earl F

“…In our previous studies, we have shown that in vitro biaxial strain (stretch) injury of neurons in neuronal plus glial cultures increases intracellular free…”
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Inhibition of the Electrogenic Na Pump Underlies Delayed Depolarization of Cortical Neurons After Mechanical Injury or Glutamate by Tavalin, Steven J, Ellis, Earl F, Satin, Leslie S

“…Steven J. Tavalin 1 , Earl F. Ellis 1 , and Leslie S. Satin 1 , 2 1  Department of Pharmacology and Toxicology and 2  Department of Physiology Medical College…”
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Traumatic injury of cultured astrocytes alters inositol (1,4,5)-trisphosphate-mediated signaling by Floyd, Candace L., Rzigalinski, Beverly A., Weber, John T., Sitterding, Heather A., Willoughby, Karen A., Ellis, Earl F.

“…Our previous studies using an in vitro model of traumatic injury have shown that stretch injury of astrocytes causes a rapid elevation in intracellular free…”
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Calcium responses to caffeine and muscarinic receptor agonists are altered in traumatically injured neurons by Weber, John T, Rzigalinski, Beverly A, Ellis, Earl F

“…A fundamental mechanism that is believed to contribute to neuronal injury and death following traumatic brain injury (TBI) is a disruption in cellular calcium…”
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Metabolism of arachidonic acid to epoxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and prostaglandins in cultured rat hippocampal astrocytes by Amruthesh, S C, Boerschel, M F, McKinney, J S, Willoughby, K A, Ellis, E F

“…We have recently shown that brain slices are capable of metabolizing arachidonic acid by the epoxygenase pathway. The purpose of this study was to begin to…”
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Effect of Ca2+ on In Vitro Astrocyte Injury by Rzigalinski, Beverly A., Liang, Shi, McKinney, Jerry S., Willoughby, Karen A., Ellis, Earl F.

“…: Current literature suggests that a massive influx of Ca2+ into the cells of the CNS induces cell damage associated with traumatic brain injury (TBI). Using…”
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