Search Results - "Elliot, Sharon J"

Exploring Animal Models That Resemble Idiopathic Pulmonary Fibrosis by Tashiro, Jun, Rubio, Gustavo A, Limper, Andrew H, Williams, Kurt, Elliot, Sharon J, Ninou, Ioanna, Aidinis, Vassilis, Tzouvelekis, Argyrios, Glassberg, Marilyn K

“…Large multicenter clinical trials have led to two recently approved drugs for patients with idiopathic pulmonary fibrosis (IPF); yet, both of these therapies…”
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Pharmacologic control of oxidative stress and inflammation determines whether diabetic glomerulosclerosis progresses or decreases: A pilot study in sclerosis-prone mice by Grosjean, Fabrizio, Yubero-Serrano, Elena M, Zheng, Feng, Esposito, Vittoria, Swamy, Shobha, Elliot, Sharon J, Cai, Weijing, Vlassara, Helen, Salem, Fadi, Striker, Gary E

“…Diabetic kidney disease (DKD) is characterized by progressive glomerulosclerosis (GS). ROP mice have a sclerosis-prone phenotype. However, they develop severe,…”
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17β-Estradiol Replacement Reverses Age-Related Lung Disease in Estrogen-Deficient C57BL/6J Mice by Glassberg, Marilyn K, Choi, Rhea, Manzoli, Vita, Shahzeidi, Shahriar, Rauschkolb, Peter, Voswinckel, Robert, Aliniazee, Muddassir, Xia, Xiaomei, Elliot, Sharon J

“…The role that estrogens play in the aging lung is poorly understood. Remodeling of the aging lung with thickening of the alveolar walls and reduction in the…”
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Inhibition of Advanced Glycation End Products (AGEs) Accumulation by Pyridoxamine Modulates Glomerular and Mesangial Cell Estrogen Receptor α Expression in Aged Female Mice by Pereira-Simon, Simone, Rubio, Gustavo A, Xia, Xiaomei, Cai, Weijing, Choi, Rhea, Striker, Gary E, Elliot, Sharon J

“…Age-related increases in oxidant stress (OS) play a role in regulation of estrogen receptor (ER) expression in the kidneys. In this study, we establish that in…”
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Estrogen Deficiency Promotes Cigarette Smoke-Induced Changes in the Extracellular Matrix in the Lungs of Aging Female Mice by Glassberg, Marilyn K., M.D, Catanuto, Paola, Ph.D, Shahzeidi, Shahriar, M.D, Aliniazee, Muddassir, M.D, Lilo, Sarit, Ph.D, Rubio, Gustavo A., M.D, Elliot, Sharon J., Ph.D

“…Abstract Female smokers have a faster decline in lung function with increasing age and overall develop a greater loss of lung function than male smokers. This…”
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Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes by Ijaz, Adeel, Tejada, Thor, Catanuto, Paola, Xia, Xiaomei, Elliot, Sharon J., Lenz, Oliver, Jauregui, Alexandra, Saenz, Maria O., Molano, Ruth D., Pileggi, Antonello, Ricordi, Camillo, Fornoni, Alessia

“…C-jun N-terminal kinase (JNK) regulates both the development of insulin resistance and inflammation. Podocytes of the widely used db/db mouse model of diabetic…”
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Estrogens and progression of diabetic kidney damage by Doublier, Sophie, Lupia, Enrico, Catanuto, Paola, Elliot, Sharon J

“…It is generally accepted that estrogens affect and modulate the development and progression of chronic kidney diseases (CKD) not related to diabetes. Clinical…”
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Activation of the Estrogen Receptor Contributes to the Progression of Pulmonary Lymphangioleiomyomatosis via Matrix Metalloproteinase-Induced Cell Invasiveness by Glassberg, Marilyn K., Elliot, Sharon J., Fritz, Jason, Catanuto, Paola, Potier, Mylene, Donahue, Roger, Stetler-Stevenson, William, Karl, Michael

“…Context: The role of estrogens in the pathogenesis of lymphangioleiomyomatosis (LAM), an aggressive and destructive, eventually fatal lung disease of women, is…”
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Stem Cell Therapy for COPD: Hope and Exploitation by Glassberg, Marilyn K, Csete, Isabelle, Simonet, Emmanuelle, Elliot, Sharon J

“…COPD is a chronic inflammatory and destructive disease characterized by progressive decline in lung function that can accelerate with aging. Preclinical…”
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Matrix metalloproteinases in renal development and disease by LENZ, O, ELLIOT, S. J, STETLER-STEVENSON, W. G

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Pentosan polysulfate inhibits atherosclerosis in Watanabe heritable hyperlipidemic rabbits: differential modulation of metalloproteinase-2 and -9 by Lupia, Enrico, Zheng, Feng, Grosjean, Fabrizio, Tack, Ivan, Doublier, Sophie, Elliot, Sharon J, Vlassara, Helen, Striker, Gary E

“…Pentosan polysulfate (PPS), a heparinoid compound essentially devoid of anticoagulant activity, modulates cell growth and decreases inflammation. We…”
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Estrogen receptor subtype expression and regulation is altered in papillary thyroid cancer after menopause by Rubio, Gustavo A., Catanuto, Paola, Glassberg, Marilyn K., Lew, John I., Elliot, Sharon J.

“…Estrogen receptors can regulate growth in papillary thyroid cancer and may affect prognosis after menopause. This study examines changes of estrogen receptor…”
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Catalase, a therapeutic target in the reversal of estrogen-mediated aging by Elliot, Sharon J., Catanuto, Paola, Pereira-Simon, Simone, Xia, Xiaomei, Pastar, Irena, Thaller, Seth, Head, Cheyanne R., Stojadinovic, Olivera, Tomic-Canic, Marjana, Glassberg, Marilyn K.

“…Despite increasing interest in the reversal of age-related processes, there is a paucity of data regarding the effects of post-menopausal-associated estrogen…”
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Mesenchymal stromal cells prevent bleomycin‐induced lung and skin fibrosis in aged mice and restore wound healing by Rubio, Gustavo A., Elliot, Sharon J., Wikramanayake, Tongyu C., Xia, Xiaomei, Pereira‐Simon, Simone, Thaller, Seth R., Glinos, George D., Jozic, Ivan, Hirt, Penelope, Pastar, Irena, Tomic‐Canic, Marjana, Glassberg, Marilyn K.

“…Fibrosis can develop in nearly any tissue leading to a wide range of chronic fibrotic diseases. However, current treatment options are limited. In this study,…”
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Testosterone and 17β-estradiol have opposite effects on podocyte apoptosis that precedes glomerulosclerosis in female estrogen receptor knockout mice by Doublier, Sophie, Lupia, Enrico, Catanuto, Paola, Periera-Simon, Simone, Xia, Xiaomei, Korach, Ken, Berho, Mariana, Elliot, Sharon J., Karl, Michael

“…Podocyte damage and apoptosis are thought to be important if not essential in the development of glomerulosclerosis. Female estrogen receptor knockout mice…”
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Therapeutic benefits of young, but not old, adipose-derived mesenchymal stem cells in a chronic mouse model of bleomycin-induced pulmonary fibrosis by Tashiro, Jun, Elliot, Sharon J, Gerth, David J, Xia, Xiaomei, Pereira-Simon, Simone, Choi, Rhea, Catanuto, Paola, Shahzeidi, Shahriar, Toonkel, Rebecca L, Shah, Rahil H, El Salem, Fadi, Glassberg, Marilyn K

“…The observation that pulmonary inflammatory lesions and bleomycin (BLM)-induced pulmonary fibrosis spontaneously resolve in young mice, whereas remaining…”
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Lung Diseases of the Elderly: Cellular Mechanisms by Ascher, Kori, Elliot, Sharon J, Rubio, Gustavo A, Glassberg, Marilyn K

“…Natural lung aging is characterized by molecular and cellular changes in multiple lung cell populations. These changes include shorter telomeres, increased…”
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Inhibition of Advanced Glycation End Products (AGEs) Accumulation by Pyridoxamine Modulates Glomerular and Mesangial Cell Estrogen Receptor [alpha] Expression in Aged Female Mice by Pereira-Simon, Simone, Rubio, Gustavo A, Xia, Xiaomei, Cai, Weijing, Choi, Rhea, Striker, Gary E, Elliot, Sharon J

“…Age-related increases in oxidant stress (OS) play a role in regulation of estrogen receptor (ER) expression in the kidneys. In this study, we establish that in…”
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Autocrine Activation of the IGF-I Signaling Pathway in Mesangial Cells Isolated From Diabetic NOD Mice by TACK, Ivan, ELLIOT, Sharon J, POTIER, Mylene, RIVERA, Ana, STRIKER, Gary E, STRIKER, Liliane J

“…Autocrine Activation of the IGF-I Signaling Pathway in Mesangial Cells Isolated From Diabetic NOD Mice Ivan Tack 1 , Sharon J. Elliot 2 , Mylene Potier 2 , Ana…”
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Anti‐fibrotic effects of different sources of MSC in bleomycin‐induced lung fibrosis in C57BL6 male mice by Periera‐Simon, Simone, Xia, Xiaomei, Catanuto, Paola, Coronado, Ramon, Kurtzberg, Joanne, Bellio, Michael, Lee, Yee‐Shuan, Khan, Aisha, Smith, Robin, Elliot, Sharon J., Glassberg, Marilyn K.

“…ABSTRACT Background and objective IPF is a fatal and debilitating lung disorder increasing in incidence worldwide. To date, two approved treatments only slow…”
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