Search Results - "Ellington, Andrew"

Diagnostic Applications of Nucleic Acid Circuits by Jung, Cheulhee, Ellington, Andrew D

“…While the field of DNA computing and molecular programming was engendered in large measure as a curiosity-driven exercise, it has taken on increasing…”
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Synthetic DNA Synthesis and Assembly: Putting the Synthetic in Synthetic Biology by Hughes, Randall A, Ellington, Andrew D

“…The chemical synthesis of DNA oligonucleotides and their assembly into synthons, genes, circuits, and even entire genomes by gene synthesis methods has become…”
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Rational, modular adaptation of enzyme-free DNA circuits to multiple detection methods by Li, Bingling, Ellington, Andrew D, Chen, Xi

“…Signal amplification is a key component of molecular detection. Enzyme-free signal amplification is especially appealing for the development of low-cost,…”
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Effective design principles for leakless strand displacement systems by Wang, Boya, Thachuk, Chris, Ellington, Andrew D., Winfree, Erik, Soloveichik, David

“…Artificially designed molecular systems with programmable behaviors have become a valuable tool in chemistry, biology, material science, and medicine. Although…”
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Machine learning-aided engineering of hydrolases for PET depolymerization by Lu, Hongyuan, Diaz, Daniel J., Czarnecki, Natalie J., Zhu, Congzhi, Kim, Wantae, Shroff, Raghav, Acosta, Daniel J., Alexander, Bradley R., Cole, Hannah O., Zhang, Yan, Lynd, Nathaniel A., Ellington, Andrew D., Alper, Hal S.

“…Plastic waste poses an ecological challenge 1 – 3 and enzymatic degradation offers one, potentially green and scalable, route for polyesters waste recycling 4…”
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A Simple, Cleated DNA Walker That Hangs on to Surfaces by Jung, Cheulhee, Allen, Peter B, Ellington, Andrew D

“…We designed and demonstrated a single-legged or unipedal walker that has a “cleat” that allows it to persistently associate with a track and make autonomous…”
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Real-time sequence-validated loop-mediated isothermal amplification assays for detection of Middle East respiratory syndrome coronavirus (MERS-CoV) by Bhadra, Sanchita, Jiang, Yu Sherry, Kumar, Mia R, Johnson, Reed F, Hensley, Lisa E, Ellington, Andrew D

“…The Middle East respiratory syndrome coronavirus (MERS-CoV), an emerging human coronavirus, causes severe acute respiratory illness with a 35% mortality rate…”
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Dynamic Programming of a DNA Walker Controlled by Protons by Yao, Dongbao, Bhadra, Sanchita, Xiong, Erhu, Liang, Haojun, Ellington, Andrew D, Jung, Cheulhee

“…We have now constructed a four-legged DNA walker based on toehold exchange reactions whose movement is controlled by alternating pH changes. A…”
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Inhibition of cell proliferation by an anti-EGFR aptamer by Li, Na, Nguyen, Hong Hanh, Byrom, Michelle, Ellington, Andrew D

“…Aptamers continue to receive interest as potential therapeutic agents for the treatment of diseases, including cancer. In order to determine whether aptamers…”
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Probing Spatial Organization of DNA Strands Using Enzyme-Free Hairpin Assembly Circuits by Li, Bingling, Jiang, Yu, Chen, Xi, Ellington, Andrew D

“…Catalyzed hairpin assembly (CHA) is a robust enzyme-free signal-amplification reaction that has a wide range of potential applications, especially in…”
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Coupling Sensitive Nucleic Acid Amplification with Commercial Pregnancy Test Strips by Du, Yan, Pothukuchy, Arti, Gollihar, Jimmy D., Nourani, Armin, Li, Bingling, Ellington, Andrew D.

“…The detection of nucleic acid biomarkers for point‐of‐care (POC) diagnostics is currently limited by technical complexity, cost, and time constraints. To…”
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Phosphorothioated Primers Lead to Loop-Mediated Isothermal Amplification at Low Temperatures by Cai, Sheng, Jung, Cheulhee, Bhadra, Sanchita, Ellington, Andrew D

“…Loop-mediated isothermal amplification (LAMP) is an extremely powerful tool for the detection of nucleic acids with high sensitivity and specificity. However,…”
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Kinetics of elementary steps in loop-mediated isothermal amplification (LAMP) show that strand invasion during initiation is rate-limiting by Dangerfield, Tyler L, Paik, Inyup, Bhadra, Sanchita, Johnson, Kenneth A, Ellington, Andrew D

“…Loop-mediated isothermal amplification (LAMP) has proven to be easier to implement than PCR for point-of-care diagnostic tests. However, the underlying…”
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Stacking nonenzymatic circuits for high signal gain by Chen, Xi, Briggs, Neima, McLain, Jeremy R., Ellington, Andrew D.

“…Signal amplification schemes that do not rely on protein enzymes show great potential in areas as abstruse as DNA computation and as applied as point-of-care…”
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Mismatches Improve the Performance of Strand-Displacement Nucleic Acid Circuits by Jiang, Yu Sherry, Bhadra, Sanchita, Li, Bingling, Ellington, Andrew D.

“…Catalytic hairpin assembly (CHA) has previously proven useful as a transduction and amplification method for nucleic acid detection. However, the two hairpin…”
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Engineered symbionts activate honey bee immunity and limit pathogens by Leonard, Sean P, Powell, J Elijah, Perutka, Jiri, Geng, Peng, Heckmann, Luke C, Horak, Richard D, Davies, Bryan W, Ellington, Andrew D, Barrick, Jeffrey E, Moran, Nancy A

“…Honey bees are essential pollinators threatened by colony losses linked to the spread of parasites and pathogens. Here, we report a new approach for…”
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Synthetic evolution by Simon, Anna J., d’Oelsnitz, Simon, Ellington, Andrew D.

“…The combination of modern biotechnologies such as DNA synthesis, λ red recombineering, CRISPR-based editing and next-generation high-throughput sequencing…”
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Pattern Generation with Nucleic Acid Chemical Reaction Networks by Wang, Siyuan S, Ellington, Andrew D

“…Biological and biochemical systems are manifestations of chemical reaction networks (CRNs). The ability to design and engineer such networks may allow the…”
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Retrons and their applications in genome engineering by Simon, Anna J, Ellington, Andrew D, Finkelstein, Ilya J

“…Abstract Precision genome editing technologies have transformed modern biology. These technologies have arisen from the redirection of natural biological…”
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Parallel molecular computation on digital data stored in DNA by Wang, Boya, Wang, Siyuan Stella, Chalk, Cameron, Ellington, Andrew D., Soloveichik, David

“…DNA is an incredibly dense storage medium for digital data. However, computing on the stored information is expensive and slow, requiring rounds of sequencing,…”
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