Search Results - "Ellenbogen, Richard G"
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Chlorotoxin Labeled Magnetic Nanovectors for Targeted Gene Delivery to Glioma
Published in ACS nano (24-08-2010)“…Glioma accounts for 80% of brain tumors and currently remains one of the most lethal forms of cancers. Gene therapy could potentially improve the dismal…”
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Doxorubicin loaded iron oxide nanoparticles overcome multidrug resistance in cancer in vitro
Published in Journal of controlled release (30-05-2011)“…Multidrug resistance (MDR) is characterized by the overexpression of ATP-binding cassette (ABC) transporters that actively pump a broad class of hydrophobic…”
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The Child Sport Concussion Assessment Tool 5th Edition (Child SCAT5): Background and rationale
Published in British journal of sports medicine (01-06-2017)“…This article presents the Child Sport Concussion Assessment Tool 5th Edition (Child SCAT5). The Sport Concussion Assessment Tool was introduced in 2004,…”
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PEI-PEG-Chitosan-Copolymer-Coated Iron Oxide Nanoparticles for Safe Gene Delivery: Synthesis, Complexation, and Transfection
Published in Advanced functional materials (24-07-2009)“…Gene therapy offers the potential of mediating disease through modification of specific cellular functions of target cells. However, effective transport of…”
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Proliferation and enrichment of CD133+ glioblastoma cancer stem cells on 3D chitosan-alginate scaffolds
Published in Biomaterials (01-11-2014)“…Abstract Emerging evidence implicates cancer stem cells (CSCs) as primary determinants of the clinical behavior of human cancers, representing an ideal target…”
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Signature morpho-electric, transcriptomic, and dendritic properties of human layer 5 neocortical pyramidal neurons
Published in Neuron (Cambridge, Mass.) (15-09-2021)“…In the neocortex, subcerebral axonal projections originate largely from layer 5 (L5) extratelencephalic-projecting (ET) neurons. The unique morpho-electric…”
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Targeting of Primary Breast Cancers and Metastases in a Transgenic Mouse Model Using Rationally Designed Multifunctional SPIONs
Published in ACS nano (27-03-2012)“…Breast cancer remains one of the most prevalent and lethal malignancies in women. The inability to diagnose small volume metastases early has limited effective…”
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In Vivo MRI Detection of Gliomas by Chlorotoxin-Conjugated Superparamagnetic Nanoprobes
Published in Small (Weinheim an der Bergstrasse, Germany) (01-03-2008)“…Converging advances in the development of nanoparticle‐based imaging probes and improved understanding of the molecular biology of brain tumors offer the…”
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Cerebral revascularization for ischemia, aneurysms, and cranial base tumors
Published in Neurosurgery (01-06-2008)“…This article extensively reviews the history, indications for bypass, choice of grafts, techniques, complications, and results after cerebral…”
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Tumor-targeted drug delivery and MRI contrast enhancement by chlorotoxin-conjugated iron oxide nanoparticles
Published in Nanomedicine (London, England) (01-08-2008)“…This study examines the capabilities of an actively targeting superparamagnetic nanoparticle to specifically deliver therapeutic and MRI contrast agents to…”
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Culture on 3D Chitosan-Hyaluronic Acid Scaffolds Enhances Stem Cell Marker Expression and Drug Resistance in Human Glioblastoma Cancer Stem Cells
Published in Advanced healthcare materials (01-12-2016)“…The lack of in vitro models that support the growth of glioblastoma (GBM) stem cells (GSCs) that underlie clinical aggressiveness hinders developing new,…”
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Tumor paint: a chlorotoxin : Cy5.5 bioconjugate for intraoperative visualization of cancer foci
Published in Cancer research (Chicago, Ill.) (15-07-2007)“…Toward the goal of developing an optical imaging contrast agent that will enable surgeons to intraoperatively distinguish cancer foci from adjacent normal…”
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Nanoparticle-mediated knockdown of DNA repair sensitizes cells to radiotherapy and extends survival in a genetic mouse model of glioblastoma
Published in Nanomedicine (01-10-2017)“…Abstract Glioblastoma (GBM) remains incurable, and recurrent tumors that rarely respond to standard-of-care radiation and chemo-therapies. Therefore,…”
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Human macrophages engineered to secrete a bispecific T cell engager support antigen-dependent T cell responses to glioblastoma
Published in Journal for immunotherapy of cancer (01-10-2020)“…BackgroundTargeted and effective treatment options are needed for solid tumors, including glioblastoma (GBM), where survival rates with standard treatments are…”
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Medicolegal issues in abusive head trauma for the pediatric neurosurgeon
Published in Neurosurgical focus (01-11-2020)“…The purpose of this article is to serve as a rational guide for the pediatric neurosurgeon in navigating common medicolegal issues that arise in the management…”
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Looking beyond year 1 in the molecular era of pediatric brain tumor diagnosis: confirmatory testing of germline variants found on tumor sequencing
Published in Frontiers in oncology (06-03-2024)“…Somatic molecular profiling of pediatric brain tumors aids with the diagnosis and treatment of patients with a variety of high- and low-grade central nervous…”
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Magnesium sulfate for neuroprotection after traumatic brain injury: a randomised controlled trial
Published in Lancet neurology (01-01-2007)“…Summary Background Traumatic brain injuries represent an important and costly health problem. Supplemental magnesium positively affects many of the processes…”
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Genetically engineered macrophages persist in solid tumors and locally deliver therapeutic proteins to activate immune responses
Published in Journal for immunotherapy of cancer (01-10-2020)“…BackgroundThough currently approved immunotherapies, including chimeric antigen receptor T cells and checkpoint blockade antibodies, have been successfully…”
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A Platform and Roadmap for Tissue Biorepositories
Published in Mayo Clinic proceedings (01-02-2024)Get full text
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