Search Results - "Ellen I. H. van der Voort"

Immunomodulatory Dendritic Cells Inhibit Th1 Responses and Arthritis via Different Mechanisms by van Duivenvoorde, Leonie M, Han, Wanda G. H, Bakker, Aleida M, Louis-Plence, Pascale, Charbonnier, Louis-Marie, Apparailly, Florence, van der Voort, Ellen I. H, Jorgensen, Christian, Huizinga, Tom W. J, Toes, Rene E. M

“…Dendritic cells (DCs) are professional APCs which have the unique ability to present both foreign and self-Ags to T cells and steer the outcome of immune…”
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Light chain skewing in autoantibodies and B-cell receptors of the citrullinated antigen-binding B-cell response in rheumatoid arthritis by Slot, Linda M, Vergroesen, Rochelle D, Kerkman, Priscilla F, Staudinger, Ellen, Reijm, Sanne, van Dooren, Hugo J, van der Voort, Ellen I H, Huizinga, Tom W J, Toes, René E M, Scherer, Hans U

“…Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 1% of the world population. RA is associated with the presence of autoantibodies, of which…”
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T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions by Schoenberger, Stephen P, Toes, Rene E. M, van der Voort, Ellen I. H, Offringa, Rienk, Melief, Cornelis J. M

“…Although in vivo priming of CD8+ cytotoxic T lymphocytes (CTLs) generally requires the participation of CD4+ T-helper lymphocytes,, the nature of the 'help'…”
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Functional Regulatory Immune Responses against Human Cartilage Glycoprotein-39 in Health vs. Proinflammatory Responses in Rheumatoid Arthritis by Jolanda H. M. van Bilsen, van Dongen, Henrike, Lard, Leroy R., Ellen I. H. van der Voort, Elferink, Diënne G., Bakker, Aleida M., André M. M. Miltenburg, Tom W. J. Huizinga, René R. P. de Vries, René E. M. Toes, van Rood, Johannes

“…The class of immune response against autoantigens could profoundly influence the onset and/or outcome of autoimmune diseases. Until now, there is only limited…”
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Transient expression of FOXP3 in human activated nonregulatory CD4+ T cells by Wang, Jun, Ioan‐Facsinay, Andreea, van der Voort, Ellen I. H., Huizinga, Tom W. J., Toes, René E. M.

“…Foxp3 plays a key role in CD4+CD25+ Treg cell function in mice and represents a specific marker for these cells. Despite the strong association between FOXP3…”
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CD40 Stimulation Leads to Effective Therapy of CD40- Tumors through Induction of Strong Systemic Cytotoxic T Lymphocyte Immunity by Geertje J. D. van Mierlo, Annemieke Th. den Boer, Medema, Jan Paul, Ellen I. H. van der Voort, Fransen, Marieke F., Offringa, Rienk, Cornelis J. M. Melief, Rene E. M. Toes

“…Adequate spontaneous activation of tumor-specific T lymphocytes in tumor-bearing hosts is rare, despite the expression of tumor antigens that are potentially…”
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Persistently activated, proliferative memory autoreactive B cells promote inflammation in rheumatoid arthritis by Kristyanto, Hendy, Blomberg, Nienke J, Slot, Linda M, van der Voort, Ellen I H, Kerkman, Priscilla F, Bakker, Aleida, Burgers, Leonie E, Ten Brinck, Robin M, van der Helm-van Mil, Annette H M, Spits, Hergen, Baeten, Dominique L, Huizinga, Tom W J, Toes, René E M, Scherer, Hans U

“…Autoreactive B cells mediate autoimmune pathology, but exactly how remains unknown. A hallmark of rheumatoid arthritis (RA), a common autoimmune disease, is…”
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Generation and Characterization of Anti–Citrullinated Protein Antibody–Producing B Cell Clones From Rheumatoid Arthritis Patients by Germar, Kristine, Fehres, Cynthia M., Scherer, Hans U., Uden, Nathalie, Pollastro, Sabrina, Yeremenko, Nataliya, Hansson, Monika, Kerkman, Priscilla F., Voort, Ellen I. H., Reed, Evan, Maassen, Hanna, Kwakkenbos, Mark J., Bakker, Arjen Q., Klareskog, Lars, Malmström, Vivianne, Vries, Niek, Toes, René E. M., Lundberg, Karin, Spits, Hergen, Baeten, Dominique L.

“…Objective Anti–citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA). Aside from autoantibody production, the function of…”
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Synovial fluid mononuclear cells provide an environment for long-term survival of antibody-secreting cells and promote the spontaneous production of anti-citrullinated protein antibodies by Kerkman, Priscilla F, Kempers, Ayla C, van der Voort, Ellen I H, van Oosterhout, Maikel, Huizinga, Tom W J, Toes, René E M, Scherer, Hans U

“…In rheumatoid arthritis (RA), observations point to a crucial role for (autoreactive) B cells in disease pathogenesis. Here, we studied whether cells from the…”
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The ACPA isotype profile reflects long-term radiographic progression in rheumatoid arthritis by van der Woude, Diane, Syversen, Silje W, van der Voort, Ellen I H, Verpoort, Kirsten N, Goll, Guro L, van der Linden, Michael P M, van der Helm-van Mil, Annette H M, van der Heijde, Désirée M F M, Huizinga, Tom W J, Kvien, Tore K, Toes, René E M

“…The presence of anti-citrullinated protein antibodies (ACPA) is a powerful predictive factor for the development and progression of rheumatoid arthritis (RA)…”
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Activation of Dendritic Cells That Cross-Present Tumor-Derived Antigen Licenses CD8+ CTL to Cause Tumor Eradication by van Mierlo, Geertje J. D, Boonman, Zita F. H. M, Dumortier, Helene M. H, den Boer, Annemieke Th, Fransen, Marieke F, Nouta, Jan, van der Voort, Ellen I. H, Offringa, Rienk, Toes, Rene E. M, Melief, Cornelis J. M

“…The fate of naive CD8(+) T cells is determined by the environment in which they encounter MHC class I presented peptide Ags. The manner in which tumor Ags are…”
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Identification and characterisation of citrullinated antigen-specific B cells in peripheral blood of patients with rheumatoid arthritis by Kerkman, Priscilla F, Fabre, Emeline, van der Voort, Ellen I H, Zaldumbide, Arnaud, Rombouts, Yoann, Rispens, Theo, Wolbink, Gertjan, Hoeben, Rob C, Spits, Hergen, Baeten, Dominique L P, Huizinga, Tom W J, Toes, René E M, Scherer, Hans U

“…Immunity to citrullinated antigens is a hallmark of rheumatoid arthritis (RA). We set out to elucidate its biology by identifying and characterising…”
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A Novel Role of Complement Factor C1q in Augmenting the Presentation of Antigen Captured in Immune Complexes to CD8+ T Lymphocytes by van Montfoort, Nadine, de Jong, Judith M. H, Schuurhuis, Danita H, van der Voort, Ellen I. H, Camps, Marcel G. M, Huizinga, Tom W. J, van Kooten, Cees, Daha, Mohamed R, Verbeek, J. Sjef, Ossendorp, Ferry, Toes, Rene E. M

“…Ag-IgG immune complexes (IC) are efficiently taken up, and Ag-derived peptides are subsequently processed and presented by APC. In vitro experiments indicate…”
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Circulating plasmablasts/plasmacells as a source of anticitrullinated protein antibodies in patients with rheumatoid arthritis by Kerkman, Priscilla F, Rombouts, Yoann, van der Voort, Ellen I H, Trouw, Leendert A, Huizinga, Tom W J, Toes, René E M, Scherer, Hans U

“…To study the characteristics and phenotype of anticitrullinated protein antibody (ACPA)-specific B cells in peripheral blood of patients with rheumatoid…”
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Control of systemic B cell-mediated autoimmune disease by nonmyeloablative conditioning and major histocompatibility complex-mismatched allogeneic bone marrow transplantation by Flierman, Roelof, Witteveen, Hendrik J., van der Voort, Ellen I.H., Huizinga, Tom W.J., de Vries, René R.P., Fibbe, Willem E., Toes, René E.M., van Laar, Jacob M.

“…Systemic autoimmune disease (AID) can be controlled with conventional therapies in most patients. However, relapses are common, leading to progressive…”
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Identification of citrullinated vimentin peptides as T cell epitopes in HLA–DR4–positive patients with rheumatoid arthritis by Feitsma, Anouk L., van der Voort, Ellen I. H., Franken, Kees L. M. C., El Bannoudi, Hanane, Elferink, Berendina G., Drijfhout, Jan W., Huizinga, Tom W. J., de Vries, René R. P., Toes, René E. M., Ioan‐Facsinay, A.

“…Objective Antibodies directed against citrullinated proteins (ACPAs) are highly specific for rheumatoid arthritis (RA). The production of ACPAs is most likely…”
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Antigen‐specific immunomodulation of collagen‐induced arthritis with tumor necrosis factor–stimulated dendritic cells by van Duivenvoorde, Leonie M., Louis‐Plence, Pascale, Apparailly, Florence, van der Voort, Ellen I. H., Huizinga, Tom W. J., Jorgensen, Christian, Toes, René E. M.

“…Objective Dendritic cells (DCs) are crucial for the initiation of T cell immunity and therefore play an important role in the initiation and regulation of…”
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Dendritic cells, but not macrophages or B cells, activate major histocompatibility complex class II‐restricted CD4+ T cells upon immune‐complex uptake in vivo by De Jong, Judith M. H., Schuurhuis, Danita H., Ioan‐Facsinay, Andreea, Welling, Mick M., Camps, Marcel G. M., Van Der Voort, Ellen I. H., Huizinga, Tom W. J., Ossendorp, Ferry, Verbeek, J. Sjef, Toes, René E. M.

“…Summary Professional antigen‐presenting cells (APC) are able to process and present exogenous antigen leading to the activation of T cells…”
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DX5+CD4+ T cells modulate cytokine production by CD4+ T cells towards IL‐10 via the production of IL‐4 by Han, Wanda G. H., van der Voort, Ellen I. H., el Bannoudi, Hanane, Louis‐Plence, Pascale, Huizinga, Tom W. J., Toes, René E. M.

“…CD4+ Th cells play a critical role in orchestrating the adaptive immune response. Uncontrolled Th1 responses are implicated in the pathogenesis of autoimmune…”
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Enhancement of Tumor Outgrowth Through CTL Tolerization After Peptide Vaccination Is Avoided by Peptide Presentation on Dendritic Cells by Toes, Rene E. M, van der Voort, Ellen I. H, Schoenberger, Stephen P, Drijfhout, Jan Wouter, van Bloois, Louis, Storm, Gert, Kast, W. Martin, Offringa, Rienk, Melief, Cornelis J. M

“…Synthetic peptide-based vaccines have been shown to induce potent protective and therapeutic T cell-mediated immunity in preclinical animal models and are now…”
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