Search Results - "Ellefsen, Barry"

A DNA Vaccine for Venezuelan Equine Encephalitis Virus Delivered by Intramuscular Electroporation Elicits High Levels of Neutralizing Antibodies in Multiple Animal Models and Provides Protective Immunity to Mice and Nonhuman Primates by Dupuy, Lesley C, Richards, Michelle J, Ellefsen, Barry, Chau, Lillian, Luxembourg, Alain, Hannaman, Drew, Livingston, Brian D, Schmaljohn, Connie S

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Human Polyclonal Antibodies Produced through DNA Vaccination of Transchromosomal Cattle Provide Mice with Post-Exposure Protection against Lethal Zaire and Sudan Ebolaviruses by Bounds, Callie E, Kwilas, Steven A, Kuehne, Ana I, Brannan, Jennifer M, Bakken, Russell R, Dye, John M, Hooper, Jay W, Dupuy, Lesley C, Ellefsen, Barry, Hannaman, Drew, Wu, Hua, Jiao, Jin-an, Sullivan, Eddie J, Schmaljohn, Connie S

“…DNA vaccination of transchromosomal bovines (TcBs) with DNA vaccines expressing the codon-optimized (co) glycoprotein (GP) genes of Ebola virus (EBOV) and…”
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Immunogenicity, safety, biodistribution and persistence of ADVAX, a prophylactic DNA vaccine for HIV-1, delivered by in vivo electroporation by Dolter, Karen E, Evans, Claire F, Ellefsen, Barry, Song, Juwan, Boente-Carrera, Mar, Vittorino, Roselle, Rosenberg, Talia J, Hannaman, Drew, Vasan, Sandhya

“…Abstract ADVAX is a DNA-based candidate HIV vaccine that was safe but weakly immunogenic when delivered intramuscularly (IM) in humans. Studies were performed…”
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Two Doses of Bovine Viral Diarrhea Virus DNA Vaccine Delivered by Electroporation Induce Long-Term Protective Immune Responses by van Drunen Littel-van den Hurk, Sylvia, Lawman, Zoe, Snider, Marlene, Wilson, Don, van den Hurk, Jan V, Ellefsen, Barry, Hannaman, Drew

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A Phase 1 clinical trial of a DNA vaccine for Venezuelan equine encephalitis delivered by intramuscular or intradermal electroporation by Hannaman, Drew, Dupuy, Lesley C, Ellefsen, Barry, Schmaljohn, Connie S

“…Abstract Venezuelan equine encephalitis virus (VEEV), a mosquito-borne alphavirus, causes periodic epizootics in equines and is a recognized biological defense…”
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Immunogenicity and malaria transmission reducing potency of Pfs48/45 and Pfs25 encoded by DNA vaccines administered by intramuscular electroporation by Datta, Dibyadyuti, Bansal, Geetha P, Gerloff, Dietlind L, Ellefsen, Barry, Hannaman, Drew, Kumar, Nirbhay

“…Abstract Pfs48/45 and Pfs25 are leading candidates for the development of Plasmodium falciparum transmission blocking vaccines (TBV). Expression of Pfs48/45 in…”
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Evaluation of the Impact of Codon Optimization and N-Linked Glycosylation on Functional Immunogenicity of Pfs25 DNA Vaccines Delivered by In Vivo Electroporation in Preclinical Studies in Mice by Datta, Dibyadyuti, Bansal, Geetha P, Kumar, Rajesh, Ellefsen, Barry, Hannaman, Drew, Kumar, Nirbhay

“…Plasmodium falciparum sexual stage surface antigen Pfs25 is a well-established candidate for malaria transmission-blocking vaccine development. Immunization…”
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Comparative functional potency of DNA vaccines encoding Plasmodium falciparum transmission blocking target antigens Pfs48/45 and Pfs25 administered alone or in combination by in vivo electroporation in rhesus macaques by Datta, Dibyadyuti, Bansal, Geetha P., Grasperge, Brooke, Martin, Dale S., Philipp, Mario, Gerloff, Dietlind, Ellefsen, Barry, Hannaman, Drew, Kumar, Nirbhay

“…Antibodies recognizing conformational epitopes in Pfs48/45, an antigen expressed on the surface of Plasmodium falciparum gametes and zygotes, have firmly…”
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Immunogenicity and transmission reducing potency of Pfs48/45 and Pfs25 encoded by DNA vaccines administered by intramuscular electroporation by Datta, Dibyadyuti, Bansal, Geetha P., Gerloff, Dietlind L., Ellefsen, Barry, Hannaman, Drew, Kumar, Nirbhay

“…Pfs48/45 and Pfs25 are leading candidates for the development of Plasmodium falciparum transmission blocking vaccines (TBV). Expression of Pfs48/45 in the…”
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Comparative performance of a licensed anthrax vaccine versus electroporation based delivery of a PA encoding DNA vaccine in rhesus macaques by Livingston, Brian D, Little, Stephen F, Luxembourg, Alain, Ellefsen, Barry, Hannaman, Drew

“…Abstract DNA vaccination is a promising immunization strategy that could be applied in the development of vaccines for a variety of prophylactic and…”
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Functional evaluation of malaria Pfs25 DNA vaccine by in vivo electroporation in olive baboons by Kumar, Rajesh, Nyakundi, Ruth, Kariuki, Thomas, Ozwara, Hastings, Nyamongo, Onkoba, Mlambo, Godfree, Ellefsen, Barry, Hannaman, Drew, Kumar, Nirbhay

“…Highlights • We evaluated DNA vaccine encoding Pfs25, a malaria vaccine candidate antigen. • DNA delivery by in vivo electroporation in baboons elicited…”
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Functional evaluation of malaria Pfs25 DNA vaccine byin vivoelectroporation in olive baboons by Kumar, Rajesh, Nyakundi, Ruth, Kariuki, Thomas, Ozwara, Hastings, Nyamongo, Onkoba, Mlambo, Godfree, Ellefsen, Barry, Hannaman, Drew, Kumar, Nirbhay

“…Plasmodium falciparumPfs25 antigen, expressed on the surface of zygotes and ookinetes, is one of the leading targets for the development of a malaria…”
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Electroporation enhances immune responses and protection induced by a bovine viral diarrhea virus DNA vaccine in newborn calves with maternal antibodies by van Drunen Littel-van den Hurk, Sylvia, Lawman, Zoe, Wilson, Don, Luxembourg, Alain, Ellefsen, Barry, van den Hurk, Jan V, Hannaman, Drew

“…Abstract Bovine viral diarrhea virus (BVDV) is one of the major pathogens in cattle. In this study, newborn calves with maternal antibodies were vaccinated…”
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Delivery of a DNA vaccine for Alzheimer's disease by electroporation versus gene gun generates potent and similar immune responses by Davtyan, Hayk, Ghochikyan, Anahit, Movsesyan, Nina, Ellefsen, Barry, Petrushina, Irina, Cribbs, David H, Hannaman, Drew, Evans, Claire F, Agadjanyan, Michael G

“…Induction of a humoral response against amyloid-β peptide may be beneficial for Alzheimer's disease (AD) patients and may alleviate the onset and progression…”
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Human Polyclonal Antibodies Produced through DNA Vaccination of Transchromosomal Cattle Provide Mice with Post-Exposure Protection against Lethal Zaire and Sudan Ebolaviruses: e0137786 by Bounds, Callie E, Kwilas, Steven A, Kuehne, Ana I, Brannan, Jennifer M, Bakken, Russell R, Dye, John M, Hooper, Jay W, Dupuy, Lesley C, Ellefsen, Barry, Hannaman, Drew

“…DNA vaccination of transchromosomal bovines (TcBs) with DNA vaccines expressing the codon-optimized (co) glycoprotein (GP) genes of Ebola virus (EBOV) and…”
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