Search Results - "Elledge, Stephen J."

How autophagy both activates and inhibits cellular senescence by Kang, Chanhee, Elledge, Stephen J.

“…Autophagy and cellular senescence are stress responses essential for homeostasis. While recent studies indicate a genetic relationship between autophagy and…”
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Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome by Davoli, Teresa, Xu, Andrew Wei, Mengwasser, Kristen E., Sack, Laura M., Yoon, John C., Park, Peter J., Elledge, Stephen J.

“…Aneuploidy has been recognized as a hallmark of cancer for more than 100 years, yet no general theory to explain the recurring patterns of aneuploidy in cancer…”
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The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons by Koren, Itay, Timms, Richard T., Kula, Tomasz, Xu, Qikai, Li, Mamie Z., Elledge, Stephen J.

“…Degrons are minimal elements that mediate the interaction of proteins with degradation machineries to promote proteolysis. Despite their central role in…”
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The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4 by Kang, Chanhee, Xu, Qikai, Martin, Timothy D., Li, Mamie Z., Demaria, Marco, Aron, Liviu, Lu, Tao, Yankner, Bruce A., Campisi, Judith, Elledge, Stephen J.

“…Cellular senescence is a terminal stress-activated program controlled by the p53 and p16(INK4a) tumor suppressor proteins. A striking feature of senescence is…”
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Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage by Wang, Bin, Elledge, Stephen J

“…The Brca1 A complex contains Brca1/Bard1, Abraxas, Rap80, and Brcc36; however, with the exception of the Brca1-Abraxas interaction, how the A complex is…”
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Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response by Elia, Andrew E.H., Boardman, Alexander P., Wang, David C., Huttlin, Edward L., Everley, Robert A., Dephoure, Noah, Zhou, Chunshui, Koren, Itay, Gygi, Steven P., Elledge, Stephen J.

“…Execution of the DNA damage response (DDR) relies upon a dynamic array of protein modifications. Using quantitative proteomics, we have globally profiled…”
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Origins of lymphatic and distant metastases in human colorectal cancer by Naxerova, Kamila, Reiter, Johannes G., Brachtel, Elena, Lennerz, Jochen K., van de Wetering, Marc, Rowan, Andrew, Cai, Tianxi, Clevers, Hans, Swanton, Charles, Nowak, Martin A., Elledge, Stephen J., Jain, Rakesh K.

“…The spread of cancer cells from primary tumors to regional lymph nodes is often associated with reduced survival. One prevailing model to explain this…”
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Harnessing homologous recombination in vitro to generate recombinant DNA via SLIC by Elledge, Stephen J, Li, Mamie Z

“…We describe a new cloning method, sequence and ligation-independent cloning (SLIC), which allows the assembly of multiple DNA fragments in a single reaction…”
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Global Identification of Modular Cullin-RING Ligase Substrates by Emanuele, Michael J., Elia, Andrew E.H., Xu, Qikai, Thoma, Claudio R., Izhar, Lior, Leng, Yumei, Guo, Ailan, Chen, Yi-Ning, Rush, John, Hsu, Paul Wei-Che, Yen, Hsueh-Chi Sherry, Elledge, Stephen J.

“…Cullin-RING ligases (CRLs) represent the largest E3 ubiquitin ligase family in eukaryotes, and the identification of their substrates is critical to…”
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The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning by Bruno, Peter M., Lu, Mengrou, Dennis, Kady A., Inam, Haider, Moore, Connor J., Sheehe, John, Elledge, Stephen J., Hemann, Michael T., Pritchard, Justin R.

“…Small molecules can affect many cellular processes. The disambiguation of these effects to identify the causative mechanisms of cell death is extremely…”
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A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response by Adamson, Britt, Smogorzewska, Agata, Sigoillot, Frederic D., King, Randall W., Elledge, Stephen J.

“…Repair of DNA double-strand breaks is critical to genomic stability and the prevention of developmental disorders and cancer. A central pathway for this repair…”
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The adaptive immune system is a major driver of selection for tumor suppressor gene inactivation by Martin, Timothy D, Patel, Rupesh S, Cook, Danielle R, Choi, Mei Yuk, Patil, Ajinkya, Liang, Anthony C, Li, Mamie Z, Haigis, Kevin M, Elledge, Stephen J

“…During tumorigenesis, tumors must evolve to evade the immune system and do so by disrupting the genes involved in antigen processing and presentation or…”
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Comprehensive serological profiling of human populations using a synthetic human virome by Xu, George J., Kula, Tomasz, Xu, Qikai, Li, Mamie Z., Vernon, Suzanne D., Ndung'u, Thumbi, Ruxrungtham, Kiat, Sanchez, Jorge, Brander, Christian, Chung, Raymond T., O'Connor, Kevin C., Walker, Bruce, Larman, H. Benjamin, Elledge, Stephen J.

“…Viral exposure—the complete history In addition to causing illness, viruses leave indelible footprints behind, because infection permanently alters the immune…”
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Functional Identification of Optimized RNAi Triggers Using a Massively Parallel Sensor Assay by Fellmann, Christof, Zuber, Johannes, McJunkin, Katherine, Chang, Kenneth, Malone, Colin D., Dickins, Ross A., Xu, Qikai, Hengartner, Michael O., Elledge, Stephen J., Hannon, Gregory J., Lowe, Scott W.

“…Short hairpin RNAs (shRNAs) provide powerful experimental tools by enabling stable and regulated gene silencing through programming of endogenous microRNA…”
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Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns by Sack, Laura Magill, Davoli, Teresa, Li, Mamie Z., Li, Yuyang, Xu, Qikai, Naxerova, Kamila, Wooten, Eric C., Bernardi, Ronald J., Martin, Timothy D., Chen, Ting, Leng, Yumei, Liang, Anthony C., Scorsone, Kathleen A., Westbrook, Thomas F., Wong, Kwok-Kin, Elledge, Stephen J.

“…Genomics has provided a detailed structural description of the cancer genome. Identifying oncogenic drivers that work primarily through dosage changes is a…”
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Polyubiquitinated PCNA Recruits the ZRANB3 Translocase to Maintain Genomic Integrity after Replication Stress by Ciccia, Alberto, Nimonkar, Amitabh V., Hu, Yiduo, Hajdu, Ildiko, Achar, Yathish Jagadheesh, Izhar, Lior, Petit, Sarah A., Adamson, Britt, Yoon, John C., Kowalczykowski, Stephen C., Livingston, David M., Haracska, Lajos, Elledge, Stephen J.

“…Completion of DNA replication after replication stress depends on PCNA, which undergoes monoubiquitination to stimulate direct bypass of DNA lesions by…”
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quantitative atlas of mitotic phosphorylation by Dephoure, Noah, Zhou, Chunshui, Villén, Judit, Beausoleil, Sean A, Bakalarski, Corey E, Elledge, Stephen J, Gygi, Steven P

“…The eukaryotic cell division cycle is characterized by a sequence of orderly and highly regulated events resulting in the duplication and separation of all…”
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A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors by Izhar, Lior, Adamson, Britt, Ciccia, Alberto, Lewis, Jedd, Pontano-Vaites, Laura, Leng, Yumei, Liang, Anthony C., Westbrook, Thomas F., Harper, J. Wade, Elledge, Stephen J.

“…Localization to sites of DNA damage is a hallmark of DNA damage response (DDR) proteins. To identify DDR factors, we screened epitope-tagged proteins for…”
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C-Terminal End-Directed Protein Elimination by CRL2 Ubiquitin Ligases by Lin, Hsiu-Chuan, Yeh, Chi-Wei, Chen, Yen-Fu, Lee, Ting-Ting, Hsieh, Pei-Yun, Rusnac, Domnita V., Lin, Sung-Ya, Elledge, Stephen J., Zheng, Ning, Yen, Hsueh-Chi S.

“…The proteolysis-assisted protein quality control system guards the proteome from potentially detrimental aberrant proteins. How miscellaneous defective…”
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Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen by Brass, Abraham L, Dykxhoorn, Derek M, Benita, Yair, Yan, Nan, Engelman, Alan, Xavier, Ramnik J, Lieberman, Judy, Elledge, Stephen J

“…HIV-1 exploits multiple host proteins during infection. We performed a large-scale small interfering RNA screen to identify host factors required by HIV-1 and…”
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