Search Results - "Elkon, K"

Ribosomal P antibody: 30 years on the road by Viana, V T, Durcan, L, Bonfa, E, Elkon, K B

“…The identity of the protein antigens targeted by anti-cytoplasmic antibodies in lupus was discovered 30 years ago. These antigens are three acidic ribosomal…”
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Impaired Fas Response and Autoimmunity in Pten$^{+/-}$ Mice by Di Cristofano, Antonio, Kotsi, Paraskevi, Peng, Yu Feng, Cordon-Cardo, Carlos, Elkon, Keith B., Pandolfi, Pier Paolo

“…Inactivating mutations in the PTEN tumor suppressor gene, encoding a phosphatase, occur in three related human autosomal dominant disorders characterized by…”
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C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: implications for systemic autoimmunity by Gershov, D, Kim, S, Brot, N, Elkon, K B

“…C-reactive protein (CRP) is a serum protein that is massively induced as part of the innate immune response to infection and tissue injury. As CRP has been…”
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Transcriptional Suppression of Interleukin-12 Gene Expression following Phagocytosis of Apoptotic Cells by Kim, Sunjung, Elkon, Keith B., Ma, Xiaojing

“…Phagocytosis of apoptotic cells usually results in an anti-inflammatory state with inhibition of proinflammatory cytokines such as IL-12. How apoptotic…”
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Complement-dependent clearance of apoptotic cells by human macrophages by Mevorach, D, Mascarenhas, J O, Gershov, D, Elkon, K B

“…Apoptotic cells are rapidly engulfed by phagocytes, but the receptors and ligands responsible for this phenomenon are incompletely characterized. Previously…”
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The Fas Protein is Expressed at High Levels on CD4+CD8+Thymocytes and Activated Mature Lymphocytes in Normal Mice but not in the Lupus-Prone Strain, MRL lpr/lpr by Drappa, Jorn, Brot, Nathan, Elkon, Keith B.

“…The lymphoproliferation (lpr) mutation in the MRL strain of mice is caused by the insertion of the early transposable element ETn in the Fas gene. The…”
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Systemic exposure to irradiated apoptotic cells induces autoantibody production by Mevorach, D, Zhou, J L, Song, X, Elkon, K B

“…During apoptotic cell death, cell surface ligands initiate phagocytosis of the dying cell. Clearance of these apoptotic cells is thought to occur without an…”
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Interleukin-10 promotes activation-induced cell death of SLE lymphocytes mediated by Fas ligand by Georgescu, L, Vakkalanka, R K, Elkon, K B, Crow, M K

“…Immune function in SLE is paradoxically characterized by active T cell help for autoantibody production, along with impaired T cell proliferative and cytokine…”
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CD40 ligation induces Apo-1/Fas expression on human B lymphocytes and facilitates apoptosis through the Apo-1/Fas pathway by Schattner, E J, Elkon, K B, Yoo, D H, Tumang, J, Krammer, P H, Crow, M K, Friedman, S M

“…The Apo-1/Fas antigen (CD95) mediates programmed cell death of lymphocytes when bound by Fas ligand or anti-Apo-1/Fas antibody. In contrast, the CD40 antigen…”
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IGM is required for efficient complement mediated phagocytosis of apoptotic cells in vivo by Ogden, Carol Anne, Kowalewski, Robert, Peng, YuFeng, Montenegro, Vivianne, Elkon, Keith B.

“…A variety of complement components have been detected on apoptotic cells and proposed to facilitate recognition and/or ingestion by phagocytes. The triggers…”
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Perforin, a cytotoxic molecule which mediates cell necrosis, is not required for the early control of mycobacterial infection in mice by LAOCHUMROONVORAPONG, P, WANG, J, LIU, C.-C, YE, W, MOREIRA, A. L, ELKON, K. B, FREEDMAN, V. H, KAPLAN, G

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The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis by Straus, Stephen E., Jaffe, Elaine S., Puck, Jennifer M., Dale, Janet K., Elkon, Keith B., Rösen-Wolff, Angela, Peters, Anke M.J., Sneller, Michael C., Hallahan, Claire W., Wang, Jin, Fischer, Roxanne E., Jackson, Christine M., Lin, Albert Y., Bäumler, Caroline, Siegert, Elke, Marx, Alexander, Vaishnaw, Akshay K., Grodzicky, Tamara, Fleisher, Thomas A., Lenardo, Michael J.

“…Lymphomas were studied in kindreds with autoimmune lymphoproliferative syndrome (ALPS; Canale-Smith syndrome), a disorder of lymphocyte homeostasis usually…”
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Variation in Adenovirus Transgene Expression between BALB/c and C57BL/6 Mice Is Associated with Differences in Interleukin-12 and Gamma Interferon Production and NK Cell Activation by Peng, Y, Falck-Pedersen, E, Elkon, K B

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The role of IgM antibodies in the recognition and clearance of apoptotic cells by Peng, YuFeng, Kowalewski, Robert, Kim, SunJung, Elkon, Keith B

“…Apoptotic cells not only translocate phosphatidylserine to the outside of the membrane, they activate phospholipases that remodel their membranes resulting in…”
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H2O2 induces monocyte apoptosis and reduces viability of Mycobacterium avium-M. intracellulare within cultured human monocytes by LAOCHUMROONVORAPONG, P, PAUL, S, ELKON, K. B, KAPLAN, G

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Adenovirus-Induced Maturation of Dendritic Cells through a PI3 Kinase-Mediated TNF-α Induction Pathway by Philpott, Nicola J., Nociari, Marcelo, Elkon, Keith B., Falck-Pedersen, Erik, Berns, Kenneth I.

“…Systemic administration of adenovirus and adenovirus vectors induces a robust innate and adaptive immune response in a variety of animal models. In tumor…”
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The defect in Fas mRNA expression in MRL/lpr mice is associated with insertion of the retrotransposon, ETn by JIA-LI CHU, DRAPPA, J, PARNASSA, A, ELKON, K. B

“…Fas is a cell surface protein of the tumor necrosis factor receptor, nerve growth factor receptor, CD40 family, and is involved in the control of lymphocyte…”
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The apoptosis-1/Fas protein in human systemic lupus erythematosus by Mysler, E, Bini, P, Drappa, J, Ramos, P, Friedman, S M, Krammer, P H, Elkon, K B

“…Three independent mutations involving the apoptosis-1 (APO-1)/Fas receptor or its putative ligand have led to lupuslike diseases associated with…”
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TNF-α-Dependent Maturation of Local Dendritic Cells is Critical for Activating the Adaptive Immune Response to Virus Infection by Trevejo, Jose M., Marino, Michael W., Philpott, Nicola, Josien, Regis, Richards, Elizabeth C., Elkon, Keith B., Falck-Pedersen, Erik

“…Tumor necrosis factor-α (TNF-α) is well recognized for its role in mediating innate immune responses. However, the mechanisms of TNF-α that influence the…”
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Fas Gene Mutations in the Canale–Smith Syndrome, an Inherited Lymphoproliferative Disorder Associated with Autoimmunity by Drappa, Jörn, Vaishnaw, Akshay K, Sullivan, Kathleen E, Chu, Jia-Li, Elkon, Keith B

“…The Canale–Smith syndrome, first described in 1967, 1 is an uncommon cause of lymphadenopathy in children. 2 – 4 Patients with the syndrome present within the…”
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