Search Results - "Elkins, Matthew R."

  • Showing 1 - 10 results of 10
Refine Results
  1. 1

    Elucidating ligand-bound structures of membrane proteins using solid-state NMR spectroscopy by Elkins, Matthew R, Hong, Mei

    Published in Current opinion in structural biology (01-08-2019)
    “…•Novel solid-state NMR distance techniques have been developed to determine cholesterol-binding sites in membrane proteins.•Solid-state NMR experiments yield…”
    Get full text
    Journal Article
  2. 2

    Cholesterol-binding site of the influenza M2 protein in lipid bilayers from solid-state NMR by Elkins, Matthew R., Williams, Jonathan K., Gelenter, Martin D., Dai, Peng, Kwon, Byungsu, Sergeyev, Ivan V., Pentelute, Bradley L., Hong, Mei

    “…The influenza M2 protein not only forms a proton channel but also mediates membrane scission in a cholesterol-dependent manner to cause virus budding and…”
    Get full text
    Journal Article
  3. 3

    Cholesterol Interaction with the Trimeric HIV Fusion Protein gp41 in Lipid Bilayers Investigated by Solid-State NMR Spectroscopy and Molecular Dynamics Simulations by Kwon, Byungsu, Mandal, Taraknath, Elkins, Matthew R., Oh, Younghoon, Cui, Qiang, Hong, Mei

    Published in Journal of molecular biology (24-07-2020)
    “…HIV-1 entry into cells is mediated by the fusion protein gp41. Cholesterol plays an important role in this virus–cell fusion, but molecular structural…”
    Get full text
    Journal Article
  4. 4

    In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments by Dregni, Aurelio J., Mandala, Venkata S., Wu, Haifan, Elkins, Matthew R., Wang, Harrison K., Hung, Ivan, DeGrado, William F., Hong, Mei

    “…Misfolding of the microtubule-binding protein tau into filamentous aggregates is characteristic of many neurodegenerative diseases such as Alzheimer’s disease…”
    Get full text
    Journal Article
  5. 5

    Direct Observation of Cholesterol Dimers and Tetramers in Lipid Bilayers by Elkins, Matthew R, Bandara, Asanga, Pantelopulos, George A, Straub, John E, Hong, Mei

    Published in The journal of physical chemistry. B (25-02-2021)
    “…Cholesterol is a ubiquitous component of mammalian cell membranes and affects membrane protein function. Although cholesterol-mediated formation of ordered…”
    Get full text
    Journal Article
  6. 6

    Structural Polymorphism of Alzheimer’s β‑Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study by Elkins, Matthew R, Wang, Tuo, Nick, Mimi, Jo, Hyunil, Lemmin, Thomas, Prusiner, Stanley B, DeGrado, William F, Stöhr, Jan, Hong, Mei

    Published in Journal of the American Chemical Society (10-08-2016)
    “…The amyloid-β (Aβ) peptide of Alzheimer’s disease (AD) forms polymorphic fibrils on the micrometer and molecular scales. Various fibril growth conditions have…”
    Get full text
    Journal Article
  7. 7

    Determining Cholesterol Binding to Membrane Proteins by Cholesterol 13 C Labeling in Yeast and Dynamic Nuclear Polarization NMR by Elkins, Matthew R, Sergeyev, Ivan V, Hong, Mei

    Published in Journal of the American Chemical Society (14-11-2018)
    “…We present a general strategy for determining the cholesterol-binding site of eukaryotic membrane proteins in native-like lipid membranes by NMR spectroscopy…”
    Get full text
    Journal Article
  8. 8

    Determining Cholesterol Binding to Membrane Proteins by Cholesterol 13C Labeling in Yeast and Dynamic Nuclear Polarization NMR by Elkins, Matthew R, Sergeyev, Ivan V, Hong, Mei

    Published in Journal of the American Chemical Society (14-11-2018)
    “…We present a general strategy for determining the cholesterol-binding site of eukaryotic membrane proteins in native-like lipid membranes by NMR spectroscopy…”
    Get full text
    Journal Article
  9. 9

    Elucidating Ligand-Bound Structures of Membrane Proteins Using Solid-State NMR Spectroscopy: Ligand binding to membrane proteins from solid-state NMR by Elkins, Matthew R., Hong, Mei

    Published in Current opinion in structural biology (20-03-2019)
    “…Magic-angle-spinning (MAS) solid-state NMR spectroscopy is a versatile technique to elucidate functionally important protein-ligand interactions in lipid…”
    Get full text
    Journal Article
  10. 10