Search Results - "Elkins, Matthew R."
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Elucidating ligand-bound structures of membrane proteins using solid-state NMR spectroscopy
Published in Current opinion in structural biology (01-08-2019)“…•Novel solid-state NMR distance techniques have been developed to determine cholesterol-binding sites in membrane proteins.•Solid-state NMR experiments yield…”
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Cholesterol-binding site of the influenza M2 protein in lipid bilayers from solid-state NMR
Published in Proceedings of the National Academy of Sciences - PNAS (05-12-2017)“…The influenza M2 protein not only forms a proton channel but also mediates membrane scission in a cholesterol-dependent manner to cause virus budding and…”
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Cholesterol Interaction with the Trimeric HIV Fusion Protein gp41 in Lipid Bilayers Investigated by Solid-State NMR Spectroscopy and Molecular Dynamics Simulations
Published in Journal of molecular biology (24-07-2020)“…HIV-1 entry into cells is mediated by the fusion protein gp41. Cholesterol plays an important role in this virus–cell fusion, but molecular structural…”
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In vitro 0N4R tau fibrils contain a monomorphic β-sheet core enclosed by dynamically heterogeneous fuzzy coat segments
Published in Proceedings of the National Academy of Sciences - PNAS (13-08-2019)“…Misfolding of the microtubule-binding protein tau into filamentous aggregates is characteristic of many neurodegenerative diseases such as Alzheimer’s disease…”
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Direct Observation of Cholesterol Dimers and Tetramers in Lipid Bilayers
Published in The journal of physical chemistry. B (25-02-2021)“…Cholesterol is a ubiquitous component of mammalian cell membranes and affects membrane protein function. Although cholesterol-mediated formation of ordered…”
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Structural Polymorphism of Alzheimer’s β‑Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study
Published in Journal of the American Chemical Society (10-08-2016)“…The amyloid-β (Aβ) peptide of Alzheimer’s disease (AD) forms polymorphic fibrils on the micrometer and molecular scales. Various fibril growth conditions have…”
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Determining Cholesterol Binding to Membrane Proteins by Cholesterol 13 C Labeling in Yeast and Dynamic Nuclear Polarization NMR
Published in Journal of the American Chemical Society (14-11-2018)“…We present a general strategy for determining the cholesterol-binding site of eukaryotic membrane proteins in native-like lipid membranes by NMR spectroscopy…”
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Determining Cholesterol Binding to Membrane Proteins by Cholesterol 13C Labeling in Yeast and Dynamic Nuclear Polarization NMR
Published in Journal of the American Chemical Society (14-11-2018)“…We present a general strategy for determining the cholesterol-binding site of eukaryotic membrane proteins in native-like lipid membranes by NMR spectroscopy…”
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Elucidating Ligand-Bound Structures of Membrane Proteins Using Solid-State NMR Spectroscopy: Ligand binding to membrane proteins from solid-state NMR
Published in Current opinion in structural biology (20-03-2019)“…Magic-angle-spinning (MAS) solid-state NMR spectroscopy is a versatile technique to elucidate functionally important protein-ligand interactions in lipid…”
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Probing the Conformation and Dynamics of Influenza a M2 Protein using Site-Directed Spin-Label EPR Spectroscopy
Published in Biophysical journal (29-01-2013)Get full text
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