Search Results - "Elkins, M"

Rapid Presumptive "Fingerprinting" of Body Fluids and Materials by ATR FT-IR Spectroscopy by Elkins, Kelly M.

“…:  Human body fluids and materials were evaluated using attenuated total reflectance Fourier transform infrared spectroscopy. Purified proteins, cosmetics, and…”
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Family-wide Structural Analysis of Human Numb-Associated Protein Kinases by Sorrell, Fiona J., Szklarz, Marta, Abdul Azeez, Kamal R., Elkins, Jon M., Knapp, Stefan

“…The highly diverse Numb-associated kinase (NAK) family has been linked to broad cellular functions including receptor-mediated endocytosis, Notch pathway…”
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Progress towards a public chemogenomic set for protein kinases and a call for contributions by Drewry, David H, Wells, Carrow I, Andrews, David M, Angell, Richard, Al-Ali, Hassan, Axtman, Alison D, Capuzzi, Stephen J, Elkins, Jonathan M, Ettmayer, Peter, Frederiksen, Mathias, Gileadi, Opher, Gray, Nathanael, Hooper, Alice, Knapp, Stefan, Laufer, Stefan, Luecking, Ulrich, Michaelides, Michael, Müller, Susanne, Muratov, Eugene, Denny, R Aldrin, Saikatendu, Kumar S, Treiber, Daniel K, Zuercher, William J, Willson, Timothy M

“…Protein kinases are highly tractable targets for drug discovery. However, the biological function and therapeutic potential of the majority of the 500+ human…”
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The 2014 Frank Stinchfield Award: The ‘Landing Zone’ for Wear and Stability in Total Hip Arthroplasty Is Smaller Than We Thought: A Computational Analysis by Elkins, Jacob M., Callaghan, John J., Brown, Thomas D.

“…Background Positioning of total hip bearings involves tradeoffs, because cup orientations most favorable in terms of stability are not necessarily ideal in…”
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Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy by Huber, Kilian V. M., Salah, Eidarus, Radic, Branka, Gridling, Manuela, Elkins, Jonathan M., Stukalov, Alexey, Jemth, Ann-Sofie, Göktürk, Camilla, Sanjiv, Kumar, Strömberg, Kia, Pham, Therese, Berglund, Ulrika Warpman, Colinge, Jacques, Bennett, Keiryn L., Loizou, Joanna I., Helleday, Thomas, Knapp, Stefan, Superti-Furga, Giulio

“…Activated RAS GTPase signalling is a critical driver of oncogenic transformation and malignant disease. Cellular models of RAS-dependent cancers have been used…”
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Comprehensive characterization of the Published Kinase Inhibitor Set by Elkins, Jonathan M, Fedele, Vita, Szklarz, Marta, Abdul Azeez, Kamal R, Salah, Eidarus, Mikolajczyk, Jowita, Romanov, Sergei, Sepetov, Nikolai, Huang, Xi-Ping, Roth, Bryan L, Al Haj Zen, Ayman, Fourches, Denis, Muratov, Eugene, Tropsha, Alex, Morris, Joel, Teicher, Beverly A, Kunkel, Mark, Polley, Eric, Lackey, Karen E, Atkinson, Francis L, Overington, John P, Bamborough, Paul, Müller, Susanne, Price, Daniel J, Willson, Timothy M, Drewry, David H, Knapp, Stefan, Zuercher, William J

“…A well-characterized library of experimental kinase inhibitors provides leads for targeting the untargeted kinome. Despite the success of protein kinase…”
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Structures of Down Syndrome Kinases, DYRKs, Reveal Mechanisms of Kinase Activation and Substrate Recognition by Soundararajan, Meera, Roos, Annette K., Savitsky, Pavel, Filippakopoulos, Panagis, Kettenbach, Arminja N., Olsen, Jesper V., Gerber, Scott A., Eswaran, Jeyanthy, Knapp, Stefan, Elkins, Jonathan M.

“…Dual-specificity tyrosine-(Y)-phosphorylation-regulated kinases (DYRKs) play key roles in brain development, regulation of splicing, and apoptosis, and are…”
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The Differentiation of Menstrual from Venous Blood and Other Body Fluids on Various Substrates Using ATR FT‐IR Spectroscopy by Quinn, Alicia A., Elkins, Kelly M.

“…Crime scene investigators and laboratory analysts use chemical tests to detect and differentiate body fluids. Testing often requires a sample of the stain, and…”
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Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer by Kang, Yun Pyo, Torrente, Laura, Falzone, Aimee, Elkins, Cody M, Liu, Min, Asara, John M, Dibble, Christian C, DeNicola, Gina M

“…NRF2 is emerging as a major regulator of cellular metabolism. However, most studies have been performed in cancer cells, where co-occurring mutations and tumor…”
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Updated protein domain annotation of the PARP protein family sheds new light on biological function by Suskiewicz, Marcin J, Munnur, Deeksha, Strømland, Øyvind, Yang, Ji-Chun, Easton, Laura E, Chatrin, Chatrin, Zhu, Kang, Baretić, Domagoj, Goffinont, Stéphane, Schuller, Marion, Wu, Wing-Fung, Elkins, Jonathan M, Ahel, Dragana, Sanyal, Sumana, Neuhaus, David, Ahel, Ivan

“…Abstract AlphaFold2 and related computational tools have greatly aided studies of structural biology through their ability to accurately predict protein…”
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Stability and Trunnion Wear Potential in Large-diameter Metal-on-Metal Total Hips: A Finite Element Analysis by Elkins, Jacob M., Callaghan, John J., Brown, Thomas D.

“…Background Large-diameter femoral heads for metal-on-metal THA hold theoretical advantages of joint stability and low bearing surface wear. However, recent…”
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Oxalyl Boronates Enable Modular Synthesis of Bioactive Imidazoles by Lee, C. Frank, Holownia, Aleksandra, Bennett, James M., Elkins, Jonathan M., St. Denis, Jeffrey D., Adachi, Shinya, Yudin, Andrei K.

“…Described herein is the preparation of oxalyl boronate building blocks and their application for the construction of heterocycles. The oxalyl unit, readily…”
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Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B by Tahtouh, Tania, Elkins, Jonathan M, Filippakopoulos, Panagis, Soundararajan, Meera, Burgy, Guillaume, Durieu, Emilie, Cochet, Claude, Schmid, Ralf S, Lo, Donald C, Delhommel, Florent, Oberholzer, Anselm E, Pearl, Laurence H, Carreaux, François, Bazureau, Jean-Pierre, Knapp, Stefan, Meijer, Laurent

“…DYRKs (dual specificity, tyrosine phosphorylation regulated kinases) and CLKs (cdc2-like kinases) are implicated in the onset and development of Alzheimer’s…”
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An AKAP-Lbc-RhoA interaction inhibitor promotes the translocation of aquaporin-2 to the plasma membrane of renal collecting duct principal cells by Schrade, Katharina, Tröger, Jessica, Eldahshan, Adeeb, Zühlke, Kerstin, Abdul Azeez, Kamal R, Elkins, Jonathan M, Neuenschwander, Martin, Oder, Andreas, Elkewedi, Mohamed, Jaksch, Sarah, Andrae, Karsten, Li, Jinliang, Fernandes, Joao, Müller, Paul Markus, Grunwald, Stephan, Marino, Stephen F, Vukićević, Tanja, Eichhorst, Jenny, Wiesner, Burkhard, Weber, Marcus, Kapiloff, Michael, Rocks, Oliver, Daumke, Oliver, Wieland, Thomas, Knapp, Stefan, von Kries, Jens Peter, Klussmann, Enno

“…Stimulation of renal collecting duct principal cells with antidiuretic hormone (arginine-vasopressin, AVP) results in inhibition of the small GTPase RhoA and…”
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Structural mechanism of synergistic activation of Aurora kinase B/C by phosphorylated INCENP by Abdul Azeez, Kamal R., Chatterjee, Sneha, Yu, Channing, Golub, Todd R., Sobott, Frank, Elkins, Jonathan M.

“…Aurora kinases B and C (AURKB/AURKC) are activated by binding to the C-terminal domain of INCENP. Full activation requires phosphorylation of two serine…”
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Development of Polymerase Chain Reaction-High-Resolution Melt Assay for Waterborne Pathogens Legionella pneumophila , Vibrio parahaemolyticus , and Camplobacter jejuni by Carr, Shannon M, Elkins, Kelly M

“…is the waterborne pathogen primarily responsible for causing both Pontiac Fever and Legionnaire's Disease in humans. is transmitted via aerosolized water…”
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Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family by Yang, Xiaowen, Lee, Wen Hwa, Sobott, Frank, Papagrigoriou, Evangelos, Robinson, Carol V., Grossmann, J. Günter, Sundström, Michael, Doyle, Declan A., Elkins, Jonathan M.

“…The seven members of the human 14-3-3 protein family regulate a diverse range of cell signaling pathways by formation of proteinprotein complexes with…”
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SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK) by Asquith, Christopher R. M, Berger, Benedict-Tilman, Wan, Jing, Bennett, James M, Capuzzi, Stephen J, Crona, Daniel J, Drewry, David H, East, Michael P, Elkins, Jonathan M, Fedorov, Oleg, Godoi, Paulo H, Hunter, Debra M, Knapp, Stefan, Müller, Susanne, Torrice, Chad D, Wells, Carrow I, Earp, H. Shelton, Willson, Timothy M, Zuercher, William J

“…We describe SGC-GAK-1 (11), a potent, selective, and cell-active inhibitor of cyclin G-associated kinase (GAK), together with a structurally related negative…”
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WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop by Agajanian, Megan J., Walker, Matthew P., Axtman, Alison D., Ruela-de-Sousa, Roberta R., Serafin, D. Stephen, Rabinowitz, Alex D., Graham, David M., Ryan, Meagan B., Tamir, Tigist, Nakamichi, Yuko, Gammons, Melissa V., Bennett, James M., Couñago, Rafael M., Drewry, David H., Elkins, Jonathan M., Gileadi, Carina, Gileadi, Opher, Godoi, Paulo H., Kapadia, Nirav, Müller, Susanne, Santiago, André S., Sorrell, Fiona J., Wells, Carrow I., Fedorov, Oleg, Willson, Timothy M., Zuercher, William J., Major, Michael B.

“…β-Catenin-dependent WNT signal transduction governs development, tissue homeostasis, and a vast array of human diseases. Signal propagation through a…”
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Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone by Torrente, Laura, Prieto-Farigua, Nicolas, Falzone, Aimee, Elkins, Cody M., Boothman, David A., Haura, Eric B., DeNicola, Gina M.

“…Alterations in the NRF2/KEAP1 pathway result in the constitutive activation of NRF2, leading to the aberrant induction of antioxidant and detoxification…”
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