Search Results - "Elkin, Rena"

Cerebrospinal and interstitial fluid transport via the glymphatic pathway modeled by optimal mass transport by Ratner, Vadim, Gao, Yi, Lee, Hedok, Elkin, Rena, Nedergaard, Maiken, Benveniste, Helene, Tannenbaum, Allen

“…The glymphatic pathway is a system which facilitates continuous cerebrospinal fluid (CSF) and interstitial fluid (ISF) exchange and plays a key role in…”
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Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System by Koundal, Sunil, Elkin, Rena, Nadeem, Saad, Xue, Yuechuan, Constantinou, Stefan, Sanggaard, Simon, Liu, Xiaodan, Monte, Brittany, Xu, Feng, Van Nostrand, William, Nedergaard, Maiken, Lee, Hedok, Wardlaw, Joanna, Benveniste, Helene, Tannenbaum, Allen

“…The glymphatic system (GS) hypothesis states that advective driven cerebrospinal fluid (CSF) influx from the perivascular spaces into the interstitial fluid…”
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Multi-scale geometric network analysis identifies melanoma immunotherapy response gene modules by Murgas, Kevin A., Elkin, Rena, Riaz, Nadeem, Saucan, Emil, Deasy, Joseph O., Tannenbaum, Allen R.

“…Melanoma response to immune-modulating therapy remains incompletely characterized at the molecular level. In this study, we assess melanoma immunotherapy…”
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Dynamic network curvature analysis of gene expression reveals novel potential therapeutic targets in sarcoma by Elkin, Rena, Oh, Jung Hun, Dela Cruz, Filemon, Norton, Larry, Deasy, Joseph O., Kung, Andrew L., Tannenbaum, Allen R.

“…Network properties account for the complex relationship between genes, making it easier to identify complex patterns in their interactions. In this work, we…”
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Geometric network analysis provides prognostic information in patients with high grade serous carcinoma of the ovary treated with immune checkpoint inhibitors by Elkin, Rena, Oh, Jung Hun, Liu, Ying L., Selenica, Pier, Weigelt, Britta, Reis-Filho, Jorge S., Zamarin, Dmitriy, Deasy, Joseph O., Norton, Larry, Levine, Arnold J., Tannenbaum, Allen R.

“…Network analysis methods can potentially quantify cancer aberrations in gene networks without introducing fitted parameters or variable selection. A new…”
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Gene interaction network analysis in multiple myeloma detects complex immune dysregulation associated with shorter survival by Simhal, Anish K., Maclachlan, Kylee H., Elkin, Rena, Zhu, Jiening, Norton, Larry, Deasy, Joseph O., Oh, Jung Hun, Usmani, Saad Z., Tannenbaum, Allen

“…The plasma cell cancer multiple myeloma (MM) varies significantly in genomic characteristics, response to therapy, and long-term prognosis. To investigate…”
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Publisher Correction: Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System by Koundal, Sunil, Elkin, Rena, Nadeem, Saad, Xue, Yuechuan, Constantinou, Stefan, Sanggaard, Simon, Liu, Xiaodan, Monte, Brittany, Xu, Feng, Nostrand, William Van, Nedergaard, Maiken, Lee, Hedok, Wardlaw, Joanna, Benveniste, Helene, Tannenbaum, Allen

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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A Vectorial Approach to Unbalanced Optimal Mass Transport by Zhu, Jiening, Elkin, Rena, Oh, Jung Hun, Deasy, Joseph O., Tannenbaum, Allen

“…Unbalanced optimal mass transport (OMT) seeks to remove the conservation of mass constraint by adding a source term to the standard continuity equation in the…”
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The glymphatic system and its role in cerebral homeostasis by Benveniste, Helene, Elkin, Rena, Heerdt, Paul M, Koundal, Sunil, Xue, Yuechuan, Lee, Hedok, Wardlaw, Joanna, Tannenbaum, Allen

“…The brain's high bioenergetic state is paralleled by high metabolic waste production. Authentic lymphatic vasculature is lacking in brain parenchyma…”
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Visualizing Fluid Flows via Regularized Optimal Mass Transport with Applications to Neuroscience by Chen, Xinan, Tran, Anh Phong, Elkin, Rena, Benveniste, Helene, Tannenbaum, Allen R.

“…The regularized optimal mass transport (rOMT) problem adds a diffusion term to the continuity equation in the original dynamic formulation of the optimal mass…”
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GlymphVIS: Visualizing Glymphatic Transport Pathways Using Regularized Optimal Transport by Elkin, Rena, Nadeem, Saad, Haber, Eldad, Steklova, Klara, Lee, Hedok, Benveniste, Helene, Tannenbaum, Allen

“…The glymphatic system (GS) is a transit passage that facil-itates brain metabolic waste removal and its dysfunction has been asso-ciated with neurodegenerative…”
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Geometric Network Analysis Defines Poor-Prognosis Subtypes in Multiple Myeloma by Simhal, Anish K, Maclachlan, Kylee H, Elkin, Rena, Zhu, Jiening, Usmani, Saad, Keats, Jonathan J, Norton, Larry, Deasy, Joseph O., Oh, Jung Hun, Tannenbaum, Allen

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Geometric graph neural networks on multi-omics data to predict cancer survival outcomes by Zhu, Jiening, Oh, Jung Hun, Simhal, Anish K., Elkin, Rena, Norton, Larry, Deasy, Joseph O., Tannenbaum, Allen

“…The advance of sequencing technologies has enabled a thorough molecular characterization of the genome in human cancers. To improve patient prognosis…”
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Cerebral amyloid angiopathy is associated with glymphatic transport reduction and time-delayed solute drainage along the neck arteries by Chen, Xinan, Liu, Xiaodan, Koundal, Sunil, Elkin, Rena, Zhu, Xiaoyue, Monte, Brittany, Xu, Feng, Dai, Feng, Pedram, Maysam, Lee, Hedok, Kipnis, Jonathan, Tannenbaum, Allen, Van Nostrand, William E, Benveniste, Helene

“…Cerebral amyloid angiopathy (CAA) is a common disease in older adults that contributes to dementia1–3. In CAA, amyloid beta (Aβ) is deposited along either…”
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P-076: Network topology analysis reveals unique multiple myeloma genomic subtypes and potential new therapeutic targets by Simhal, Anish, Maclachlan, Kylee, Elkin, Rena, Zhu, Jiening, Usmani, Saad, Deasy, Joseph O., Oh, Jung Hun, Tannenbaum, Allen

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Regularized Dynamical Optimal Mass Transport for Medical Image Analysis and Visualization by Elkin, Rena

“…Dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) allows for real-time analysis of disease pathology that used to only be possible post-mortem…”
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Optimal mass transport kinetic modeling for head and neck DCE‐MRI: Initial analysis by Elkin, Rena, Nadeem, Saad, LoCastro, Eve, Paudyal, Ramesh, Hatzoglou, Vaios, Lee, Nancy Y., Shukla‐Dave, Amita, Deasy, Joseph O., Tannenbaum, Allen

“…Purpose Current state‐of‐the‐art models for estimating the pharmacokinetic parameters do not account for intervoxel movement of the contrast agent (CA). We…”
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Abstract 6541: Geometry of gene expression network reveals potential novel indicator in Ewing sarcoma by Elkin, Rena, Oh, Jung Hun, Dela Cruz, Filemon, Norton, Larry, Deasy, Joseph O., Kung, Andrew L., Tannenbaum, Allen R.

“…Abstract Oncogenic driver mutations in different pediatric sarcoma subtypes have been identified but may not be druggable. In general, identifying novel…”
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Abstract 5367: Deep neural networks using protein-protein network information predict multiple myeloma survival by Zhu, Jiening, Oh, Jung Hun, Simhal, Anish K., Elkin, Rena, Norton, Larry, Deasy, Joseph O., Tannenbaum, Allen R.

“…Abstract The modern development of sequencing technologies provides a comprehensive molecular portrait of human cancers. There is a strong need to develop…”
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Abstract 2061: Protein network analysis uncovers a poor-survival subtype in multiple myeloma by Simhal, Anish K., Maclachlan, Kylee H., Elkin, Rena, Zhu, Jiening, Usmani, Saad Z., Keats, Jonathan J., Norton, Larry, Deasy, Joseph O., Oh, Jung Hun, Tannenbaum, Allen

“…Abstract Multiple myeloma (MM) prognosis incorporates a variety of metrics including treatment received, clinical factors, and genomic characteristics, with…”
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