Search Results - "Elke Schaeffeler"

Impact of Genetic Polymorphisms of ABCB1 (MDR1, P-Glycoprotein) on Drug Disposition and Potential Clinical Implications: Update of the Literature by Wolking, Stefan, Schaeffeler, Elke, Lerche, Holger, Schwab, Matthias, Nies, Anne T.

“…ATP-binding cassette transporter B1 (ABCB1; P-glycoprotein; multidrug resistance protein 1) is an adenosine triphosphate (ATP)-dependent efflux transporter…”
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Hepatic solute carrier transporters and drug therapy: Regulation of expression and impact of genetic variation by Nies, Anne T., Schaeffeler, Elke, Schwab, Matthias

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Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy by Fisel, Pascale, Schaeffeler, Elke, Schwab, Matthias

“…The solute carrier (SLC) SLC16 gene family comprises 14 members and encodes for monocarboxylate transporters (MCTs), which mediate the absorption and…”
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Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry by Schaeffeler, Elke, Jaeger, Simon U., Klumpp, Verena, Yang, Jun J., Igel, Svitlana, Hinze, Laura, Stanulla, Martin, Schwab, Matthias

“…Severe hematotoxicity in patients with thiopurine therapy has been associated with genetic polymorphisms in the thiopurine S-methyltransferase (TPMT). While…”
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Mechanisms and assessment of statin‐related muscular adverse effects by Moßhammer, Dirk, Schaeffeler, Elke, Schwab, Matthias, Mörike, Klaus

“…Statin‐associated muscular adverse effects cover a wide range of symptoms, including asymptomatic increase of creatine kinase serum activity and…”
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Impact of Membrane Drug Transporters on Resistance to Small-Molecule Tyrosine Kinase Inhibitors by Neul, Claudia, Schaeffeler, Elke, Sparreboom, Alex, Laufer, Stefan, Schwab, Matthias, Nies, Anne T

“…Small-molecule inhibitors of tyrosine kinases (TKIs) are the mainstay of treatment for many malignancies and represent novel treatment options for other…”
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Metformin and cancer: from the old medicine cabinet to pharmacological pitfalls and prospects by Emami Riedmaier, Arian, Fisel, Pascale, Nies, Anne T, Schaeffeler, Elke, Schwab, Matthias

“…Metformin is a biguanide derivative used in the treatment of type II diabetes (T2D) and one of the world's most widely prescribed drugs. Owing to its safety…”
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Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver by Nies, Anne T., Koepsell, Hermann, Winter, Stefan, Burk, Oliver, Klein, Kathrin, Kerb, Reinhold, Zanger, Ulrich M., Keppler, Dietrich, Schwab, Matthias, Schaeffeler, Elke

“…An important function of hepatocytes is the biotransformation and elimination of various drugs, many of which are organic cations and are taken up by organic…”
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Proton pump inhibitors inhibit metformin uptake by organic cation transporters (OCTs) by Nies, Anne T, Hofmann, Ute, Resch, Claudia, Schaeffeler, Elke, Rius, Maria, Schwab, Matthias

“…Metformin, an oral insulin-sensitizing drug, is actively transported into cells by organic cation transporters (OCT) 1, 2, and 3 (encoded by SLC22A1, SLC22A2,…”
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Role of Genetic and Nongenetic Factors for Fluorouracil Treatment-Related Severe Toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group by SCHWAB, Matthias, ZANGER, Ulrich M, BOKEMEYER, Carsten, EICHELBAUM, Michel, MARX, Claudia, SCHAEFFELER, Elke, KLEIN, Kathrin, DIPPON, Jürgen, KERB, Reinhold, BLIEVERNICHT, Julia, FISCHER, Joachim, HOFMANN, Ute

“…To assess the predictive value of polymorphisms in dihydropyrimidine dehydrogenase (DPYD ), thymidylate synthase (TYMS ), and methylene tetrahydrofolate…”
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Combinations of common SNPs of the transporter gene ABCB1 influence apparent bioavailability, but not renal elimination of oral digoxin by Hsin, Chih-hsuan, Stoffel, Marc S., Gazzaz, Malaz, Schaeffeler, Elke, Schwab, Matthias, Fuhr, Uwe, Taubert, Max

“…Effects of different genotypes on the pharmacokinetics of probe substrates may support their use as phenotyping agents for the activity of the respective…”
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Selective p38α MAP kinase/MAPK14 inhibition in enzymatically modified LDL‐stimulated human monocytes: implications for atherosclerosis by Cheng, Fei, Twardowski, Laura, Fehr, Sarah, Aner, Christoph, Schaeffeler, Elke, Joos, Thomas, Knorpp, Thomas, Dorweiler, Bernhard, Laufer, Stefan, Schwab, Matthias, Torzewski, Michael

“…ABSTRACT The first ATP‐competitive p38a MAPK/MAPK14 inhibitor with excellent in vivo efficacy and selectivity, skepinone‐L, is now available. We investigated…”
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Selective Inhibition of the Lactate Transporter MCT4 Reduces Growth of Invasive Bladder Cancer by Todenhöfer, Tilman, Seiler, Roland, Stewart, Craig, Moskalev, Igor, Gao, Jian, Ladhar, Simroop, Kamjabi, Alireza, Al Nakouzi, Nader, Hayashi, Tetsuharo, Choi, Stephen, Wang, Yuzhuo, Frees, Sebastian, Daugaard, Mads, Oo, Htoo Zarni, Fisel, Pascale, Schwab, Matthias, Schaeffeler, Elke, Douglas, James, Hennenlotter, Jörg, Bedke, Jens, Gibb, Ewan A, Fazli, Ladan, Stenzl, Arnulf, Black, Peter C

“…The significance of lactate transporters has been recognized in various cancer types, but their role in urothelial carcinoma remains mostly unknown. The aim of…”
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Copy number variation profiling in pharmacogenes using panel-based exome resequencing and correlation to human liver expression by Tremmel, Roman, Klein, Kathrin, Battke, Florian, Fehr, Sarah, Winter, Stefan, Scheurenbrand, Tim, Schaeffeler, Elke, Biskup, Saskia, Schwab, Matthias, Zanger, Ulrich M.

“…Structural variants including copy number variations (CNV) have gained widespread attention, especially in pharmacogenomics but for several genes functional…”
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Novel drug transporter substrates identification: An innovative approach based on metabolomic profiling, in silico ligand screening and biological validation by Nies, Anne T., König, Jörg, Leuthold, Patrick, Damme, Katja, Winter, Stefan, Haag, Mathias, Masuda, Satohiro, Kruck, Stephan, Daniel, Hannelore, Spanier, Britta, Fromm, Martin F., Bedke, Jens, Inui, Ken-ichi, Schwab, Matthias, Schaeffeler, Elke

“…Solute carrier (SLC) transport proteins are fundamental for the translocation of endogenous compounds and drugs across membranes, thus playing a critical role…”
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Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia by Stanulla, Martin, Schaeffeler, Elke, Möricke, Anja, Buchmann, Swantje, Zimmermann, Martin, Igel, Svitlana, Schmiegelow, Kjeld, Flotho, Christian, Hartmann, Hans, Illsinger, Sabine, Sauerbrey, Axel, Junk, Stefanie V., Schütte, Peter, Hinze, Laura, Lauten, Melchior, Modlich, Simon, Kolb, Reinhard, Rossig, Claudia, Schwabe, Georg, Gnekow, Astrid K., Fleischhack, Gudrun, Schlegel, Paul Gerhard, Schünemann, Holger J., Kratz, Christian P., Cario, Gunnar, Schrappe, Martin, Schwab, Matthias

“…Long-term treatment with 6-thioguanine (6-TG) for pediatric acute lymphoblastic leukemia (ALL) is associated with high rates of hepatic sinusoidal obstruction…”
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Platelet miRNAs: differential expression in coronary artery disease and associations with course of left ventricular systolic function by Goldschmied, Andreas, Drotleff, Bernhard, Winter, Stefan, Schaeffeler, Elke, Schwab, Matthias, Gawaz, Meinrad, Geisler, Tobias, Rath, Dominik

“…MicroRNAs are paramount in post transcriptional gene regulation. We investigated platelet miRNAs in patients with CAD and examined potential associations with…”
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Aberrant splicing caused by single nucleotide polymorphism c.516G>T [Q172H], a marker of CYP2B66, is responsible for decreased expression and activity of CYP2B6 in liver by Hofmann, Marco H, Blievernicht, Julia K, Klein, Kathrin, Saussele, Tanja, Schaeffeler, Elke, Schwab, Matthias, Zanger, Ulrich M

“…CYP2B6 is a polymorphic human drug metabolizing cytochrome P450 with clinical relevance for several drug substrates including cyclophosphamide, bupropion, and…”
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Reduced Paneth Cell α-Defensins in Ileal Crohn's Disease by Jan Wehkamp, Salzman, Nita H., Edith Porter, Sabine Nuding, Michael Weichenthal, Robert E. Petras, Shen, Bo, Elke Schaeffeler, Matthias Schwab, Rose Linzmeier, Ryan W. Feathers, Hiutung Chu, Heriberto Lima, Jr, Klaus Fellermann, Ganz, Tomas, Stange, Eduard F., Bevins, Charles L.

“…The pathogenesis of Crohn's disease (CD), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and…”
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No association of genetic variants in TLR4, TNF-α, IL10, IFN-γ, and IL37 in cytomegalovirus-positive renal allograft recipients with active CMV infection-Subanalysis of the prospective randomised VIPP study by Mazzola, Pascale, Schaeffeler, Elke, Witzke, Oliver, Nitschke, Martin, Kliem, Volker, Zortel, Max, Wagner, Eva-Maria, Schwab, Matthias, Hauser, Ingeborg A

“…Cytomegalovirus (CMV) infection is amongst the most important factors complicating solid organ transplantation. In a large prospective randomized clinical…”
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