Search Results - "Elkamhawy, Ahmed"

The Journey of DDR1 and DDR2 Kinase Inhibitors as Rising Stars in the Fight Against Cancer by Elkamhawy, Ahmed, Lu, Qili, Nada, Hossam, Woo, Jiyu, Quan, Guofeng, Lee, Kyeong

“…Discoidin domain receptor (DDR) is a collagen-activated receptor tyrosine kinase that plays critical roles in regulating essential cellular processes such as…”
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Structure Activity Relationship of Key Heterocyclic Anti-Angiogenic Leads of Promising Potential in the Fight against Cancer by Nada, Hossam, Elkamhawy, Ahmed, Lee, Kyeong

“…Pathological angiogenesis is a hallmark of cancer; accordingly, a number of anticancer FDA-approved drugs act by inhibiting angiogenesis via different…”
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Diabetes mellitus: Classification, mediators, and complications; A gate to identify potential targets for the development of new effective treatments by Antar, Samar A., Ashour, Nada A., Sharaky, Marwa, Khattab, Muhammad, Ashour, Naira A., Zaid, Roaa T., Roh, Eun Joo, Elkamhawy, Ahmed, Al-Karmalawy, Ahmed A.

“…Nowadays, diabetes mellitus has emerged as a significant global public health concern with a remarkable increase in its prevalence. This review article focuses…”
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Identification of 1H-purine-2,6-dione derivative as a potential SARS-CoV-2 main protease inhibitor: molecular docking, dynamic simulations, and energy calculations by Nada, Hossam, Elkamhawy, Ahmed, Lee, Kyeong

“…The rapid spread of the coronavirus since its first appearance in 2019 has taken the world by surprise, challenging the global economy, and putting pressure on…”
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Emerging Therapeutic Strategies for Parkinson's Disease and Future Prospects: A 2021 Update by Gouda, Noha A, Elkamhawy, Ahmed, Cho, Jungsook

“…Parkinson's disease (PD) is a neurodegenerative disorder pathologically distinguished by degeneration of dopaminergic neurons in the substantia nigra pars…”
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Small Molecule c-KIT Inhibitors for the Treatment of Gastrointestinal Stromal Tumors: A Review on Synthesis, Design Strategies, and Structure-Activity Relationship (SAR) by Godesi, Sreenivasulu, Lee, Joohan, Nada, Hossam, Quan, Guofeng, Elkamhawy, Ahmed, Choi, Yongseok, Lee, Kyeong

“…The proto-oncogenic protein, c-KIT, plays a crucial role in regulating cellular transformation and differentiation processes, such as proliferation, survival,…”
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Suppression of Tumor Growth and Cell Migration by Indole-Based Benzenesulfonamides and Their Synergistic Effects in Combination with Doxorubicin by Nguyen, Phuong Linh, Elkamhawy, Ahmed, Choi, Young Hee, Lee, Chang Hoon, Lee, Kyeong, Cho, Jungsook

“…Pharmacological inhibition of the enzyme activity targeting carbonic anhydrases (CAs) demonstrated antiglaucoma and anticancer effects through pH control…”
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4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies by Nada, Hossam, Elkamhawy, Ahmed, Abdellattif, Magda H., Angeli, Andrea, Lee, Chang Hoon, Supuran, Claudiu T., Lee, Kyeong

“…Human carbonic anhydrase inhibitors (hCAIs) are a key therapeutic class with a multitude of novel applications such as anticonvulsants, topically acting…”
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New horizons in drug discovery of lymphocyte-specific protein tyrosine kinase (Lck) inhibitors: a decade review (2011-2021) focussing on structure-activity relationship (SAR) and docking insights by Elkamhawy, Ahmed, Ali, Eslam M. H., Lee, Kyeong

“…Lymphocyte-specific protein tyrosine kinase (Lck), a non-receptor Src family kinase, has a vital role in various cellular processes such as cell cycle control,…”
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Identification of Novel and Potent Indole-Based Benzenesulfonamides as Selective Human Carbonic Anhydrase II Inhibitors: Design, Synthesis, In Vitro, and In Silico Studies by Elkamhawy, Ahmed, Woo, Jiyu, Nada, Hossam, Angeli, Andrea, Bedair, Tarek M, Supuran, Claudiu T, Lee, Kyeong

“…In recent decades, human carbonic anhydrase inhibitors (hCAIs) have emerged as an important therapeutic class with various applications including antiglaucoma,…”
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Synthesis, Biological Evaluation, and In Silico Studies of New Heterocycles Incorporating 4,5,6,7-Tetrabromophthalimide Moiety as Potential Antibacterial and Anticancer Agents by H. Abdellattif, Magda, Elkamhawy, Ahmed, Nada, Hossam

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Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers by El-Kalyoubi, Samar, Khalifa, Mohamed M., Abo-Elfadl, Mahmoud T., El-Sayed, Ahmed A., Elkamhawy, Ahmed, Lee, Kyeong, Al-Karmalawy, Ahmed A.

“…A new wave of dual Topo I/II inhibitors was designed and synthesised via the hybridisation of spirooxindoles and pyrimidines. In situ selenium nanoparticles…”
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Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies by Farouk, Faten, Elmaaty, Ayman Abo, Elkamhawy, Ahmed, Tawfik, Haytham O., Alnajjar, Radwan, Abourehab, Mohammed A. S., Saleh, Mohamed A., Eldehna, Wagdy M., Al-Karmalawy, Ahmed A.

“…Topoisomerase II (TOP-2) is a promising molecular target for cancer therapy. Numerous antibiotics could interact with biologically relevant macromolecules and…”
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Hit Identification of a Novel Quinazoline Sulfonamide as a Promising EphB3 Inhibitor: Design, Virtual Combinatorial Library, Synthesis, Biological Evaluation, and Docking Simulation Studies by Lee, Kyeong, Nada, Hossam, Byun, Hyun Jung, Lee, Chang Hoon, Elkamhawy, Ahmed

“…EphB3 is a major key player in a variety of cellular activities, including cell migration, proliferation, and apoptosis. However, the exact role of EphB3 in…”
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Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2′,3′:4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity by Mourad, Mai A. E., Abo Elmaaty, Ayman, Zaki, Islam, Mourad, Ahmed A. E., Hofni, Amal, Khodir, Ahmed E., Aboubakr, Esam M., Elkamhawy, Ahmed, Roh, Eun Joo, Al-Karmalawy, Ahmed A.

“…Topoisomerases II are ubiquitous enzymes with significant genotoxic effects in many critical DNA processes. Additionally, epidermal growth factor receptor…”
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Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening by Elkamhawy, Ahmed, Ammar, Usama M., Paik, Sora, Abdellattif, Magda H., Elsherbeny, Mohamed H., Lee, Kyeong, Roh, Eun Joo

“…Recently, multitargeted drugs are considered a potential approach in treating cancer. In this study, twelve in-house indole-based derivatives were preliminary…”
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EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor by Elkamhawy, Ahmed, Hassan, Ahmed H.E., Paik, Sora, Sup Lee, Yong, Lee, Hwi-Ho, Shin, Ji-Sun, Lee, Kyung-Tae, Roh, Eun Joo

“…[Display omitted] •Compound 4d is an anti-inflammatory EGFR inhibitor.•Compound 4d inhibits LPS-induced NO, IL-1β, IL-6 and TNF-α production.•Compound 4d…”
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Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B by Elkamhawy, Ahmed, Paik, Sora, Kim, Hyeon Jeong, Park, Jong-Hyun, Londhe, Ashwini M., Lee, Kyeong, Pae, Ae Nim, Park, Ki Duk, Roh, Eun Joo

“…Herein, two new series of N-substituted indole-based analogues were rationally designed, synthesized via microwave heating technology, and evaluated as…”
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Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines by Son, Seohyun, Elkamhawy, Ahmed, Gul, Anam Rana, Al-Karmalawy, Ahmed A., Alnajjar, Radwan, Abdeen, Ahmed, Ibrahim, Samah F., Alshammari, Saud O., Alshammari, Qamar A., Choi, Won Jun, Park, Tae Jung, Lee, Kyeong

“…Epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) protein tyrosine kinases co-expressed in various cancers such as…”
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New N-Alkylated Heterocyclic Compounds as Prospective NDM1 Inhibitors: Investigation of In Vitro and In Silico Properties by Kaddouri, Yassine, Bouchal, Btissam, Abrigach, Farid, El Kodadi, Mohamed, Bellaoui, Mohammed, Elkamhawy, Ahmed, Touzani, Rachid, Abdellattif, Magda H.

“…A new family of pyrazole-based compounds (1–15) was synthesized and characterized using different physicochemical analyses, such as FTIR, UV-Visible, 1H, 13C…”
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