Search Results - "Elkaeed, Eslam B."

Computational Insights on the Potential of Some NSAIDs for Treating COVID-19: Priority Set and Lead Optimization by Abo Elmaaty, Ayman, Hamed, Mohammed I A, Ismail, Muhammad I, B Elkaeed, Eslam, S Abulkhair, Hamada, Khattab, Muhammad, Al-Karmalawy, Ahmed A

“…The discovery of drugs capable of inhibiting SARS-CoV-2 is a priority for human beings due to the severity of the global health pandemic caused by COVID-19. To…”
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Design, Synthesis, Docking, DFT, MD Simulation Studies of a New Nicotinamide-Based Derivative: In Vitro Anticancer and VEGFR-2 Inhibitory Effects by Elkaeed, Eslam B., Yousef, Reda G., Elkady, Hazem, Gobaara, Ibraheem M. M., Alsfouk, Bshra A., Husein, Dalal Z., Ibrahim, Ibrahim M., Metwaly, Ahmed M., Eissa, Ibrahim H.

“…A nicotinamide-based derivative was designed as an antiproliferative VEGFR-2 inhibitor with the key pharmacophoric features needed to interact with the VEGFR-2…”
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Molecular Docking and Dynamics Simulation Revealed the Potential Inhibitory Activity of ACEIs Against SARS-CoV-2 Targeting the hACE2 Receptor by Al-Karmalawy, Ahmed A., Dahab, Mohammed A., Metwaly, Ahmed M., Elhady, Sameh S., Elkaeed, Eslam B., Eissa, Ibrahim H., Darwish, Khaled M.

“…The rapid and global spread of a new human coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has produced an immediate urgency to…”
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New benzoxazole derivatives as potential VEGFR-2 inhibitors and apoptosis inducers: design, synthesis, anti-proliferative evaluation, flowcytometric analysis, and in silico studies by Elkady, Hazem, Elwan, Alaa, El-Mahdy, Hesham A., Doghish, Ahmed S., Ismail, Ahmed, Taghour, Mohammed S., Elkaeed, Eslam B., Eissa, Ibrahim H., Dahab, Mohammed A., Mahdy, Hazem A., Khalifa, Mohamed M.

“…A new series of benzoxazole derivatives were designed and synthesised to have the main essential pharmacophoric features of VEGFR-2 inhibitors. Cytotoxic…”
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Topo II inhibition and DNA intercalation by new phthalazine-based derivatives as potent anticancer agents: design, synthesis, anti-proliferative, docking, and in vivo studies by Khalifa, Mohamed M., Al-Karmalawy, Ahmed A., Elkaeed, Eslam B., Nafie, Mohamed S., Tantawy, Mohamed A., Eissa, Ibrahim H., Mahdy, Hazem A.

“…This research presents the design and synthesis of a novel series of phthalazine derivatives as Topo II inhibitors, DNA intercalators, and cytotoxic agents. In…”
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In Silico Studies of Some Isoflavonoids as Potential Candidates against COVID-19 Targeting Human ACE2 (hACE2) and Viral Main Protease (Mpro) by Alesawy, Mohamed S., Abdallah, Abdallah E., Taghour, Mohammed S., Elkaeed, Eslam B., H. Eissa, Ibrahim, Metwaly, Ahmed M.

“…The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the “COVID-19” disease that has been declared by WHO as a global emergency. The…”
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In Silico Screening of Semi-Synthesized Compounds as Potential Inhibitors for SARS-CoV-2 Papain-like Protease: Pharmacophoric Features, Molecular Docking, ADMET, Toxicity and DFT Studies by Alesawy, Mohamed S, Elkaeed, Eslam B, Alsfouk, Aisha A, Metwaly, Ahmed M, Eissa, Ibrahim H

“…Papain-like protease is an essential enzyme in the proteolytic processing required for the replication of SARS-CoV-2. Accordingly, such an enzyme is an…”
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Design and synthesis of thiazolidine-2,4-diones hybrids with 1,2-dihydroquinolones and 2-oxindoles as potential VEGFR-2 inhibitors: in-vitro anticancer evaluation and in-silico studies by Taghour, Mohammed S., Elkady, Hazem, Eldehna, Wagdy M., El-Deeb, Nehal M., Kenawy, Ahmed M., Elkaeed, Eslam B., Alsfouk, Aisha A., Alesawy, Mohamed S., Metwaly, Ahmed M., Eissa, Ibrahim. H.

“…A thiazolidine-2,4-dione nucleus was molecularly hybridised with the effective antitumor moieties; 2-oxo-1,2-dihydroquinoline and 2-oxoindoline to obtain new…”
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A Multistage In Silico Study of Natural Potential Inhibitors Targeting SARS-CoV-2 Main Protease by Elkaeed, Eslam B., Eissa, Ibrahim H., Elkady, Hazem, Abdelalim, Ahmed, Alqaisi, Ahmad M., Alsfouk, Aisha A., Elwan, Alaa, Metwaly, Ahmed M.

“…Among a group of 310 natural antiviral natural metabolites, our team identified three compounds as the most potent natural inhibitors against the SARS-CoV-2…”
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In Silico Exploration of Potential Natural Inhibitors against SARS-Cov-2 nsp10 by Eissa, Ibrahim H., Khalifa, Mohamed M., Elkaeed, Eslam B., Hafez, Elsayed E., Alsfouk, Aisha A., Metwaly, Ahmed M.

“…In continuation of our previous effort, different in silico selection methods were applied to 310 naturally isolated metabolites that exhibited antiviral…”
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Multi-Step In Silico Discovery of Natural Drugs against COVID-19 Targeting Main Protease by Elkaeed, Eslam B., Youssef, Fadia S., Eissa, Ibrahim H., Elkady, Hazem, Alsfouk, Aisha A., Ashour, Mohamed L., El Hassab, Mahmoud A., Abou-Seri, Sahar M., Metwaly, Ahmed M.

“…In continuation of our antecedent work against COVID-19, three natural compounds, namely, Luteoside C (130), Kahalalide E (184), and Streptovaricin B (278)…”
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New Anticancer Theobromine Derivative Targeting EGFRWT and EGFRT790M: Design, Semi-Synthesis, In Silico, and In Vitro Anticancer Studies by Elkaeed, Eslam B., Yousef, Reda G., Elkady, Hazem, Alsfouk, Aisha A., Husein, Dalal Z., Ibrahim, Ibrahim M., Metwaly, Ahmed M., Eissa, Ibrahim H.

“…Based on the pharmacophoric features of EGFR inhibitors, a new semisynthetic theobromine-derived compound was designed to interact with the catalytic pocket of…”
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( E )- N -(3-(1-(2-(4-(2,2,2-Trifluoroacetamido)benzoyl)hydrazono)ethyl)phenyl)nicotinamide: A Novel Pyridine Derivative for Inhibiting Vascular Endothelial Growth Factor Receptor-2: Synthesis, Computational, and Anticancer Studies by Yousef, Reda G, Elkady, Hazem, Elkaeed, Eslam B, Gobaara, Ibraheem M M, Al-Ghulikah, Hanan A, Husein, Dalal Z, Ibrahim, Ibrahim M, Metwaly, Ahmed M, Eissa, Ibrahim H

“…( )- -(3-(1-(2-(4-(2,2,2-Trifluoroacetamido)benzoyl)hydrazono)ethyl)phenyl)nicotinamide (compound ) was designed as an antiangiogenic VEGFR-2 inhibitor with…”
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Discovery of new quinolines as potent colchicine binding site inhibitors: design, synthesis, docking studies, and anti-proliferative evaluation by Hagras, Mohamed, El Deeb, Moshira A., Elzahabi, Heba S. A., Elkaeed, Eslam B., Mehany, Ahmed B. M., Eissa, Ibrahim H.

“…Discovering of new anticancer agents with potential activity against tubulin polymerisation is still a promising approach. Colchicine binding site inhibitors…”
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Design, synthesis, anti-proliferative evaluation, docking, and MD simulations studies of new thiazolidine-2,4-diones targeting VEGFR-2 and apoptosis pathway by Taghour, Mohammed S, Elkady, Hazem, Eldehna, Wagdy M, El-Deeb, Nehal, Kenawy, Ahmed M, Elkaeed, Eslam B, Alsfouk, Bshra A, Alesawy, Mohamed S, Husein, Dalal Z, Metwaly, Ahmed M, Eissa, Ibrahim H

“…We report herein, the design and synthesis of thiazolidine-2,4-diones derivatives as new inhibitors for VEGFR-2. The designed members were assessed for their…”
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Ligand and Structure-Based In Silico Determination of the Most Promising SARS-CoV-2 nsp16-nsp10 2'- o -Methyltransferase Complex Inhibitors among 3009 FDA Approved Drugs by Eissa, Ibrahim H, Alesawy, Mohamed S, Saleh, Abdulrahman M, Elkaeed, Eslam B, Alsfouk, Bshra A, El-Attar, Abdul-Aziz M M, Metwaly, Ahmed M

“…As a continuation of our earlier work against SARS-CoV-2, seven FDA-approved drugs were designated as the best SARS-CoV-2 nsp16-nsp10 2'- -methyltransferase…”
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New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies by Elkaeed, Eslam B., Taghour, Mohammed S., Mahdy, Hazem A., Eldehna, Wagdy M., El-Deeb, Nehal M., Kenawy, Ahmed M., A. Alsfouk, Bshra, Dahab, Mohammed A., Metwaly, Ahmed M., Eissa, Ibrahim H., El-Zahabi, Mohamed A.

“…New quinoline and isatin derivatives having the main characteristics of VEGFR-2 inhibitors was synthesised. The antiproliferative effects of these compounds…”
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Modified Benzoxazole-Based VEGFR-2 Inhibitors and Apoptosis Inducers: Design, Synthesis, and Anti-Proliferative Evaluation by Elwan, Alaa, Abdallah, Abdallah E, Mahdy, Hazem A, Dahab, Mohammed A, Taghour, Mohammed S, Elkaeed, Eslam B, Mehany, Ahmed B M, Nabeeh, Ahmed, Adel, Mohammed, Alsfouk, Aisha A, Elkady, Hazem, Eissa, Ibrahim H

“…This work is one of our efforts to discover potent anticancer agents. We modified the most promising derivative of our previous work concerned with the…”
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Isolation and In Silico Anti-SARS-CoV-2 Papain-Like Protease Potentialities of Two Rare 2-Phenoxychromone Derivatives from Artemisia spp by Suleimen, Yerlan M, Jose, Rani A, Suleimen, Raigul N, Arenz, Christoph, Ishmuratova, Margarita, Toppet, Suzanne, Dehaen, Wim, Alsfouk, Aisha A, Elkaeed, Eslam B, Eissa, Ibrahim H, Metwaly, Ahmed M

“…Two rare 2-phenoxychromone derivatives, 6-demethoxy-4`-O-capillarsine ( ) and tenuflorin C ( ), were isolated from the areal parts of and respectively, for the…”
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Synthesis of Novel Benzimidazole-Based Thiazole Derivatives as Multipotent Inhibitors of α-Amylase and α-Glucosidase: In Vitro Evaluation along with Molecular Docking Study by Hussain, Rafaqat, Iqbal, Shahid, Shah, Mazloom, Rehman, Wajid, Khan, Shoaib, Rasheed, Liaqat, Rahim, Fazal, Dera, Ayed A, Kehili, Sana, Elkaeed, Eslam B, Awwad, Nasser S, Bajaber, Majed A, Alahmdi, Mohammed Issa, Alrbyawi, Hamad, Alsaab, Hashem O

“…In this study, hybrid analogs of benzimidazole containing a thiazole moiety (1–17) were afforded and then tested for their ability to inhibit α-amylase and…”
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