Oxidative stress markers in neonatal respiratory distress syndrome: advanced oxidation protein products and 8-hydroxy-2-deoxyguanosine in relation to disease severity

Objective We assessed oxidant–antioxidant status and evaluated the role of lipid peroxidation, oxidative DNA damage, and protein oxidation in the development and severity of neonatal respiratory distress syndrome (RDS). Methods Forty preterm neonates with RDS were compared with another 40 preterm ne...

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Published in:	Pediatric research Vol. 87; no. 1; pp. 74 - 80
Main Authors:	Elkabany, Zeinab A., El-Farrash, Rania A., Shinkar, Dina M., Ismail, Eman A., Nada, Ahmed S., Farag, Ahmed S., Elsayed, Medhat A., Salama, Dina H., Macken, Eman L., Gaballah, Saleh A.
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01-01-2020 Nature Publishing Group
Subjects:	8-Hydroxy-2'-Deoxyguanosine - blood Advanced Oxidation Protein Products - blood Antioxidants Biomarkers - blood Birth Weight Case-Control Studies Clinical Clinical Research Article DNA Damage Female Gestational Age Humans Infant, Low Birth Weight Infant, Newborn Infant, Premature Lipid Peroxidation Male Malondialdehyde - blood Medicine Medicine & Public Health Oxidation Oxidative Stress Pediatric Surgery Pediatrics Prospective Studies Protein Carbonylation Proteins Respiratory distress syndrome Respiratory Distress Syndrome, Newborn - blood Respiratory Distress Syndrome, Newborn - diagnosis Respiratory Distress Syndrome, Newborn - genetics Respiratory therapy Severity of Illness Index Time Factors Ventilators
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Summary:	Objective We assessed oxidant–antioxidant status and evaluated the role of lipid peroxidation, oxidative DNA damage, and protein oxidation in the development and severity of neonatal respiratory distress syndrome (RDS). Methods Forty preterm neonates with RDS were compared with another 40 preterm neonates without RDS enrolled as controls. Total antioxidant capacity (TAC), malondialdehyde (MDA), advanced oxidation protein products (AOPPs), 8-hydroxy-2-deoxyguanosine (8-OHdG), and trace elements (copper and zinc) were measured in cord blood (day 0) for all neonates and repeated on day 3 for the RDS group. Results Day 0 serum levels of MDA, AOPPs, and 8-OHdG were significantly higher in neonates with RDS than controls with a further increase on day 3. Days 0 and 3 levels of TAC, copper, and zinc were significantly lower in the RDS group compared with controls. Elevated serum levels of 8-OHdG and AOPPs were associated with severe RDS, invasive mechanical ventilation, and high mortality rate. 8-OHdG and AOPPs were positively correlated with MDA, oxygenation index, duration of ventilation, and duration of hospitalization. Conclusions Increased lipid, protein, and DNA oxidation is accompanied by alterations in the antioxidant defense status, which may play a role in the pathogenesis and severity of RDS.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0031-3998 1530-0447
DOI:	10.1038/s41390-019-0464-y