Search Results - "Elizalde, Patricia"
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Tumor Necrosis Factor α Blockade: An Opportunity to Tackle Breast Cancer
Published in Frontiers in oncology (22-04-2020)“…Breast cancer is the most frequently diagnosed cancer and the principal cause of mortality by malignancy in women and represents a main problem for public…”
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Harnessing Tumor Necrosis Factor Alpha to Achieve Effective Cancer Immunotherapy
Published in Cancers (02-02-2021)“…Tumor necrosis factor alpha (TNFα) is a pleiotropic cytokine known to have contradictory roles in oncoimmunology. Indeed, TNFα has a central role in the onset…”
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Correction: Activation of ErbB-2 via a hierarchical interaction between ErbB-2 and type I insulin-like growth factor receptor in mammary tumor cells
Published in Oncogene (06-10-2023)Get full text
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Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis
Published in Cancer research (Chicago, Ill.) (01-02-2018)“…Resistance to cancer treatment can be driven by epigenetic reprogramming of specific transcriptomes in favor of the refractory phenotypes. Here we discover…”
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ErbB-2 nuclear function in breast cancer growth, metastasis and resistance to therapy
Published in Endocrine-related cancer (01-12-2016)“…Approximately 15–20% of breast cancers (BC) show either membrane overexpression of ErbB-2 (MErbB-2), a member of the ErbBs family of receptor tyrosine kinases,…”
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Steroid hormone receptors: A South American perspective
Published in Steroids (01-03-2020)Get full text
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TNFα-Induced Mucin 4 Expression Elicits Trastuzumab Resistance in HER2-Positive Breast Cancer
Published in Clinical cancer research (01-02-2017)“…Although trastuzumab administration improved the outcome of HER2-positive breast cancer patients, resistance events hamper its clinical benefits. We…”
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Downregulation of the tumor-suppressor miR-16 via progestin-mediated oncogenic signaling contributes to breast cancer development
Published in Breast cancer research : BCR (14-05-2012)“…Experimental and clinical evidence points to a critical role of progesterone and the nuclear progesterone receptor (PR) in controlling mammary gland…”
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Revisiting progesterone receptor (PR) actions in breast cancer: Insights into PR repressive functions
Published in Steroids (01-05-2018)“…Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls developmental processes and proliferation and differentiation…”
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Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth
Published in Breast cancer research : BCR (06-12-2014)“…The transcription factor GATA3 is involved in mammary gland development and is crucial for the maintenance of the differentiated status of luminal epithelial…”
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Retraction Note: Progesterone receptor assembly of a transcriptional complex along with activator protein 1, signal transducer and activator of transcription 3 and ErbB-2 governs breast cancer growth and predicts response to endocrine therapy
Published in Breast cancer research : BCR (02-11-2023)Get full text
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Blocking soluble TNFα sensitizes HER2-positive breast cancer to trastuzumab through MUC4 downregulation and subverts immunosuppression
Published in Journal for immunotherapy of cancer (01-03-2023)“…BackgroundThe success of HER2-positive (HER2+) breast cancer treatment with trastuzumab, an antibody that targets HER2, relies on immune response. We…”
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Correction: Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer
Published in Cell death & disease (15-12-2023)Get full text
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Small interfering RNA targeted to IGF-IR delays tumor growth and induces proinflammatory cytokines in a mouse breast cancer model
Published in PloS one (03-01-2012)“…Insulin-like growth factor I (IGF-I) and its type I receptor (IGF-IR) play significant roles in tumorigenesis and in immune response. Here, we wanted to know…”
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p42/p44 MAPK-mediated Stat3Ser727 phosphorylation is required for progestin-induced full activation of Stat3 and breast cancer growth
Published in Endocrine-related cancer (01-04-2013)“…Stat3 is a signaling node for multiple oncogenic pathways and is therefore frequently active in breast cancer. As experimental and clinical evidence reveals…”
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Halting ErbB-2 isoforms retrograde transport to the nucleus as a new theragnostic approach for triple-negative breast cancer
Published in Cell death & disease (09-05-2022)“…Triple-negative breast cancer (TNBC) is clinically defined by the absence of estrogen and progesterone receptors and the lack of membrane overexpression or…”
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Progesterone Receptor Induces ErbB-2 Nuclear Translocation To Promote Breast Cancer Growth via a Novel Transcriptional Effect: ErbB-2 Function as a Coactivator of Stat3
Published in Molecular and Cellular Biology (01-12-2010)“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Regulation of telomere homeostasis and genomic stability in cancer by N 6 -adenosine methylation (m 6 A)
Published in Science advances (01-07-2021)“…Down-regulation of HMBOX1 via METTL3-catalyzed m 6 A causes genomic instability driven by telomere dysfunction in cancer. The role of RNA methylation on N 6…”
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Invasive micropapillary carcinoma of the breast overexpresses MUC4 and is associated with poor outcome to adjuvant trastuzumab in HER2-positive breast cancer
Published in BMC cancer (28-12-2017)“…Invasive micropapillary carcinoma of the breast (IMPC) is a histological tumor variant that occurs with low frequency characterized by an inside-out formation…”
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