Search Results - "Elisseeff, Jennifer H."

Enhanced lubrication on tissue and biomaterial surfaces through peptide-mediated binding of hyaluronic acid by Singh, Anirudha, Corvelli, Michael, Unterman, Shimon A., Wepasnick, Kevin A., McDonnell, Peter, Elisseeff, Jennifer H.

“…Lubrication is key for the efficient function of devices and tissues with moving surfaces, such as articulating joints, ocular surfaces and the lungs. Indeed,…”
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IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis by Faust, Heather J, Zhang, Hong, Han, Jin, Wolf, Matthew T, Jeon, Ok Hee, Sadtler, Kaitlyn, Peña, Alexis N, Chung, Liam, Maestas, Jr, David R, Tam, Ada J, Pardoll, Drew M, Campisi, Judith, Housseau, Franck, Zhou, Daohong, Bingham, 3rd, Clifton O, Elisseeff, Jennifer H

“…Senescent cells (SnCs) are implicated in the pathogenesis of age-related diseases including osteoarthritis (OA), in part via expression of a…”
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Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity by He, Yonghan, Zhang, Xuan, Chang, Jianhui, Kim, Ha-Neui, Zhang, Peiyi, Wang, Yingying, Khan, Sajid, Liu, Xingui, Zhang, Xin, Lv, Dongwen, Song, Lin, Li, Wen, Thummuri, Dinesh, Yuan, Yaxia, Wiegand, Janet S., Ortiz, Yuma T., Budamagunta, Vivekananda, Elisseeff, Jennifer H., Campisi, Judith, Almeida, Maria, Zheng, Guangrong, Zhou, Daohong

“…Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the potential to prevent and treat various age-related diseases and extend…”
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Cellular senescence in musculoskeletal homeostasis, diseases, and regeneration by Wan, Mei, Gray-Gaillard, Elise F, Elisseeff, Jennifer H

“…Emerging insights into cellular senescence highlight the relevance of senescence in musculoskeletal disorders, which represent the leading global cause of…”
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Bioinspired nanofibers support chondrogenesis for articular cartilage repair by Coburn, Jeannine M, Gibson, Matthew, Monagle, Sean, Patterson, Zachary, Elisseeff, Jennifer H

“…Articular cartilage repair remains a significant and growing clinical challenge with the aging population. The native extracellular matrix (ECM) of articular…”
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Human iPSC-derived osteoblasts and osteoclasts together promote bone regeneration in 3D biomaterials by Jeon, Ok Hee, Panicker, Leelamma M., Lu, Qiaozhi, Chae, Jeremy J., Feldman, Ricardo A., Elisseeff, Jennifer H.

“…Bone substitutes can be designed to replicate physiological structure and function by creating a microenvironment that supports crosstalk between bone and…”
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Design, clinical translation and immunological response of biomaterials in regenerative medicine by Sadtler, Kaitlyn, Singh, Anirudha, Wolf, Matthew T., Wang, Xiaokun, Pardoll, Drew M., Elisseeff, Jennifer H.

“…The field of regenerative medicine aims to replace tissues lost as a consequence of disease, trauma or congenital abnormalities. Biomaterials serve as…”
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Proteomic composition and immunomodulatory properties of urinary bladder matrix scaffolds in homeostasis and injury by Sadtler, Kaitlyn, Sommerfeld, Sven D, Wolf, Matthew T, Wang, Xiaokun, Majumdar, Shoumyo, Chung, Liam, Kelkar, Dhanashree S, Pandey, Akhilesh, Elisseeff, Jennifer H

“…Graphical abstract…”
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Evolution of Autologous Chondrocyte Repair and Comparison to Other Cartilage Repair Techniques by Dewan, Ashvin K., Gibson, Matthew A., Elisseeff, Jennifer H., Trice, Michael E.

“…Articular cartilage defects have been addressed using microfracture, abrasion chondroplasty, or osteochondral grafting, but these strategies do not generate…”
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An In Vitro Model for the Ocular Surface and Tear Film System by Lu, Qiaozhi, Yin, Hongbo, Grant, Michael P., Elisseeff, Jennifer H.

“…Dry eye is a complicated ocular surface disease whose exact pathogenesis is not yet fully understood. For the therapeutic evaluation and pathogenesis study of…”
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An Injectable Adipose Matrix for Soft-Tissue Reconstruction by Wu, Iwen, Nahas, Zayna, Kimmerling, Kelly A., Rosson, Gedge D., Elisseeff, Jennifer H.

“…Soft-tissue repair is currently limited by the availability of autologous tissue sources and the absence of an ideal soft-tissue replacement comparable to…”
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Time to Relax: Mechanical Stress Release Guides Stem Cell Responses by Sommerfeld, Sven D., Elisseeff, Jennifer H.

“…Stem cells integrate spatiotemporal cues, including the mechanical properties of their microenvironment, into their fate decisions. Chaudhuri et al. (2015)…”
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Glycolysis is the primary bioenergetic pathway for cell motility and cytoskeletal remodeling in human prostate and breast cancer cells by Shiraishi, Takumi, Verdone, James E, Huang, Jessie, Kahlert, Ulf D, Hernandez, James R, Torga, Gonzalo, Zarif, Jelani C, Epstein, Tamir, Gatenby, Robert, McCartney, Annemarie, Elisseeff, Jennifer H, Mooney, Steven M, An, Steven S, Pienta, Kenneth J

“…The ability of a cancer cell to detach from the primary tumor and move to distant sites is fundamental to a lethal cancer phenotype. Metabolic transformations…”
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Modular Multifunctional Poly(ethylene glycol) Hydrogels for Stem Cell Differentiation by Singh, Anirudha, Zhan, Jianan, Ye, Zhaoyang, Elisseeff, Jennifer H.

“…Synthetic polymers are employed to create highly defined microenvironments with controlled biochemical and biophysical properties for cell culture and tissue…”
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Autologous Protein Solution processing alters lymphoid and myeloid cell populations and modulates gene expression dependent on cell type by Peña, Alexis N, Sommerfeld, Sven D, Anderson, Amy E, Han, Jin, Maestas, Jr, David R, Mejias, Joscelyn C, Woodell-May, Jennifer, King, William, Ganguly, Sudipto, Elisseeff, Jennifer H

“…Osteoarthritis (OA) is a degenerative disease associated with cartilage degradation, osteophyte formation, and fibrillation. Autologous Protein Solution (APS),…”
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Engineering structurally organized cartilage and bone tissues by Sharma, Blanka, Elisseeff, Jennifer H

“…The field of tissue engineering promises to deliver biological substitutes to repair or replace tissues in the body that have been injured or diseased. The…”
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Metabolic variations in normal and fibrotic human laryngotracheal‐derived fibroblasts: A Warburg‐like effect by Ma, Garret, Samad, Idris, Motz, Kevin, Yin, Linda X., Duvvuri, Madhavi V., Ding, Dacheng, Namba, Daryan R., Elisseeff, Jennifer H., Horton, Maureen R., Hillel, Alexander T.

“…Objectives/Hypothesis Laryngotracheal stenosis (LTS) is a chronic fibrotic disease characterized by fibroblast proliferation, collagen deposition, and matrix…”
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Hyaluronic acid-binding scaffold for articular cartilage repair by Unterman, Shimon A, Gibson, Matthew, Lee, Janice H, Crist, Joshua, Chansakul, Thanissara, Yang, Elaine C, Elisseeff, Jennifer H

“…Hyaluronic acid (HA) is an extracellular matrix molecule with multiple physical and biological functions found in many tissues, including cartilage. HA has…”
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Regulating synthetic gene networks in 3D materials by Deans, Tara L, Singh, Anirudha, Gibson, Matthew, Elisseeff, Jennifer H

“…Combining synthetic biology and materials science will enable more advanced studies of cellular regulatory processes, in addition to facilitating therapeutic…”
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Mimicking biological functionality with polymers for biomedical applications by Green, Jordan J., Elisseeff, Jennifer H.

“…The vast opportunities for biomaterials design and functionality enabled by mimicking nature continue to stretch the limits of imagination. As both biological…”
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