Search Results - "Elijah S. Lawrence"
-
1
Seq-ing Higher Ground: Functional Investigation of Adaptive Variation Associated With High-Altitude Adaptation
Published in Frontiers in genetics (14-05-2020)“…Human populations at high altitude exhibit both unique physiological responses and strong genetic signatures of selection thought to compensate for the…”
Get full text
Journal Article -
2
Combined intermittent and sustained hypoxia is a novel and deleterious cardio-metabolic phenotype
Published in Sleep (New York, N.Y.) (13-06-2022)“…Abstract Study Objectives Chronic obstructive pulmonary disease and obstructive sleep apnea overlap syndrome is associated with excess mortality, and outcomes…”
Get full text
Journal Article -
3
Genetic variants at the EGLN1 locus associated with high‐altitude adaptation in Tibetans are absent or found at low frequency in highland Andeans
Published in Annals of human genetics (01-05-2019)“…EGLN1 encodes the hypoxia‐inducible factor (HIF) pathway prolyl hydroxylase 2 (PHD2) that serves as an oxygen‐sensitive regulator of HIF activity. The EGLN1…”
Get full text
Journal Article -
4
Time Domains of Hypoxia Responses and -Omics Insights
Published in Frontiers in physiology (08-08-2022)“…The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts…”
Get full text
Journal Article -
5
Analysis of SARS-CoV-2 RNA Persistence across Indoor Surface Materials Reveals Best Practices for Environmental Monitoring Programs
Published in mSystems (21-12-2021)“…Environmental monitoring in public spaces can be used to identify surfaces contaminated by persons with coronavirus disease 2019 (COVID-19) and inform…”
Get full text
Journal Article -
6
SARS-CoV-2 Distribution in Residential Housing Suggests Contact Deposition and Correlates with Rothia sp
Published in mSystems (28-06-2022)“…Monitoring severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on surfaces is emerging as an important tool for identifying past exposure to…”
Get full text
Journal Article -
7
Genetic Missense Variants at the EGLN1 Locus Associated with High‐Altitude Adaptation in Tibetans are Rare in Andeans
Published in The FASEB journal (01-04-2018)“…High‐altitude populations have been challenged by chronic hypoxia for many generations and demonstrate some of the most rapid evolution observed in humans…”
Get full text
Journal Article -
8
Functional EPAS1 / HIF2A missense variant is associated with hematocrit in Andean highlanders
Published in Science advances (09-02-2024)“…Hypoxia-inducible factor pathway genes are linked to adaptation in both human and nonhuman highland species. , a notable target of hypoxia adaptation, is…”
Get full text
Journal Article -
9
Implementation of Practical Surface SARS-CoV-2 Surveillance in School Settings
Published in mSystems (30-08-2022)“…Surface sampling for SARS-CoV-2 RNA detection has shown considerable promise to detect exposure of built environments to infected individuals shedding virus…”
Get full text
Journal Article -
10
Safer at school early alert: an observational study of wastewater and surface monitoring to detect COVID-19 in elementary schoolsResearch in context
Published in Lancet Regional Health - Americas (Online) (01-03-2023)“…Background: Schools are high-risk settings for SARS-CoV-2 transmission, but necessary for children's educational and social-emotional wellbeing. Previous…”
Get full text
Journal Article -
11
Sentinel Cards Provide Practical SARS-CoV-2 Monitoring in School Settings
Published in mSystems (30-08-2022)“…A promising approach to help students safely return to in person learning is through the application of sentinel cards for accurate high resolution…”
Get full text
Journal Article