Search Results - "Elif Nihal Korkmaz"
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Skip residues modulate the structural properties of the myosin rod and guide thick filament assembly
Published in Proceedings of the National Academy of Sciences - PNAS (21-07-2015)“…The rod of sarcomeric myosins directs thick filament assembly and is characterized by the insertion of four skip residues that introduce discontinuities in the…”
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2
Identification of the Ah-receptor structural determinants for ligand preferences
Published in Toxicological sciences (01-09-2012)“…The aryl hydrocarbon receptor (AHR) is a transcription factor that responds to diverse ligands and plays a critical role in toxicology, immune function, and…”
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Conformational control of the binding of the transactivation domain of the MLL protein and c-Myb to the KIX domain of CREB
Published in PLoS computational biology (2012)“…The KIX domain of CBP is a transcriptional coactivator. Concomitant binding to the activation domain of proto-oncogene protein c-Myb and the transactivation…”
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4
De novo design of high-affinity binders of bioactive helical peptides
Published in Nature (London) (08-02-2024)“…Many peptide hormones form an α-helix on binding their receptors 1 – 4 , and sensitive methods for their detection could contribute to better clinical…”
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Specificity landscapes unmask submaximal binding site preferences of transcription factors
Published in Proceedings of the National Academy of Sciences - PNAS (06-11-2018)“…We have developed Differential Specificity and Energy Landscape (DiSEL) analysis to comprehensively compare DNA–protein interactomes (DPIs) obtained by…”
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Interplay of Electrostatics and Hydrophobic Effects in the Metamorphic Protein Human Lymphotactin
Published in The journal of physical chemistry. B (30-07-2015)“…The human lymphotactin (hLtn) is a protein that features two native states both of which are physiologically relevant: it is a monomer (hLtn10) at 10 °C with…”
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