Search Results - "Eliasson, Lena"

A circular RNA generated from an intron of the insulin gene controls insulin secretion by Stoll, Lisa, Rodríguez-Trejo, Adriana, Guay, Claudiane, Brozzi, Flora, Bayazit, Mustafa Bilal, Gattesco, Sonia, Menoud, Véronique, Sobel, Jonathan, Marques, Ana Claudia, Venø, Morten Trillingsgaard, Esguerra, Jonathan Lou S., Barghouth, Mohammad, Suleiman, Mara, Marselli, Lorella, Kjems, Jørgen, Eliasson, Lena, Renström, Erik, Bouzakri, Karim, Pinget, Michel, Marchetti, Piero, Regazzi, Romano

“…Fine-tuning of insulin release from pancreatic β-cells is essential to maintain blood glucose homeostasis. Here, we report that insulin secretion is regulated…”
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Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes by Bacos, Karl, Gillberg, Linn, Volkov, Petr, Olsson, Anders H, Hansen, Torben, Pedersen, Oluf, Gjesing, Anette Prior, Eiberg, Hans, Tuomi, Tiinamaija, Almgren, Peter, Groop, Leif, Eliasson, Lena, Vaag, Allan, Dayeh, Tasnim, Ling, Charlotte

“…Aging associates with impaired pancreatic islet function and increased type 2 diabetes (T2D) risk. Here we examine whether age-related epigenetic changes…”
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Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion by Dayeh, Tasnim, Volkov, Petr, Salö, Sofia, Hall, Elin, Nilsson, Emma, Olsson, Anders H, Kirkpatrick, Clare L, Wollheim, Claes B, Eliasson, Lena, Rönn, Tina, Bacos, Karl, Ling, Charlotte

“…Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect disease susceptibility. To describe the human methylome in pancreatic…”
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miR-483-5p associates with obesity and insulin resistance and independently associates with new onset diabetes mellitus and cardiovascular disease by Gallo, Widet, Esguerra, Jonathan Lou S, Eliasson, Lena, Melander, Olle

“…Our aim was to identify serum microRNAs (miRNAs) in healthy humans which associate with future onset of both diabetes mellitus and cardiovascular disease. We…”
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Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis by Volkov, Petr, Bacos, Karl, Ofori, Jones K, Esguerra, Jonathan Lou S, Eliasson, Lena, Rönn, Tina, Ling, Charlotte

“…Current knowledge about the role of epigenetics in type 2 diabetes (T2D) remains limited. Only a few studies have investigated DNA methylation of selected…”
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Exposure to maternal obesity programs sex differences in pancreatic islets of the offspring in mice by Nicholas, Lisa M., Nagao, Mototsugu, Kusinski, Laura C., Fernandez-Twinn, Denise S., Eliasson, Lena, Ozanne, Susan E.

“…Aims/hypothesis Obesity during pregnancy increases offspring type 2 diabetes risk. Given that nearly half of women of child-bearing age in many populations are…”
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Selectively bred rodent models for studying the etiology of type 2 diabetes: Goto-Kakizaki rats and Oikawa-Nagao mice by Nagao, Mototsugu, Asai, Akira, Eliasson, Lena, Oikawa, Shinichi

“…Type 2 diabetes (T2D) is a polygenic disease and studies to understand the etiology of the disease have required selectively bred animal models with polygenic…”
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Global genomic and transcriptomic analysis of human pancreatic islets reveals novel genes influencing glucose metabolism by Fadista, João, Vikman, Petter, Laakso, Emilia Ottosson, Mollet, Inês Guerra, Esguerra, Jonathan Lou, Taneera, Jalal, Storm, Petter, Osmark, Peter, Ladenvall, Claes, Prasad, Rashmi B., Hansson, Karin B., Finotello, Francesca, Uvebrant, Kristina, Ofori, Jones K., Di Camillo, Barbara, Krus, Ulrika, Cilio, Corrado M., Hansson, Ola, Eliasson, Lena, Rosengren, Anders H., Renström, Erik, Wollheim, Claes B., Groop, Leif

“…Significance We provide a comprehensive catalog of novel genetic variants influencing gene expression and metabolic phenotypes in human pancreatic islets. The…”
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HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells by Daneshpajooh, Mahboubeh, Bacos, Karl, Bysani, Madhusudhan, Bagge, Annika, Ottosson Laakso, Emilia, Vikman, Petter, Eliasson, Lena, Mulder, Hindrik, Ling, Charlotte

“…Aims/hypothesis Pancreatic beta cell dysfunction is a prerequisite for the development of type 2 diabetes. Histone deacetylases (HDACs) may affect pancreatic…”
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Apolipoprotein A-I priming via SR-BI and ABCA1 receptor binding upregulates mitochondrial metabolism to promote insulin secretion in INS-1E cells by Claire L. Lyons Elaine Cowan Oktawia Nilsson, Manca Mohar, Peña-Martínez, Pablo, Lena Eliasson Jens O. Lagerstedt

“…Apolipoprotein A-I (ApoA-I), the primary component of high-density lipoprotein (HDL) cholesterol primes β-cells to increase insulin secretion, however, the…”
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MicroRNAs in islet hormone secretion by Esguerra, Jonathan L. S., Nagao, Mototsugu, Ofori, Jones K., Wendt, Anna, Eliasson, Lena

“…Pancreatic islet hormone secretion is central in the maintenance of blood glucose homeostasis. During development of hyperglycaemia, the β‐cell is under…”
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Islet microRNAs in health and type-2 diabetes by Wendt, Anna, Esguerra, Jonathan LS, Eliasson, Lena

“…•Type-2 diabetes (T2D) is a disease of many subtypes, with impaired β-cell function as main contributing factor.•MicroRNAs can act as an environment-dependent…”
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Differential glucose-regulation of microRNAs in pancreatic islets of non-obese type 2 diabetes model Goto-Kakizaki rat by Esguerra, Jonathan Lou S, Bolmeson, Caroline, Cilio, Corrado M, Eliasson, Lena

“…The Goto-Kakizaki (GK) rat is a well-studied non-obese spontaneous type 2 diabetes (T2D) animal model characterized by impaired glucose-stimulated insulin…”
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Islet Function in the Pathogenesis of Cystic Fibrosis-Related Diabetes Mellitus by Westholm, Efraim, Wendt, Anna, Eliasson, Lena

“…Cystic fibrosis-related diabetes mellitus (CFRD) is the most common non-pulmonary co-morbidity in cystic fibrosis (CF). CF is caused by mutations in the cystic…”
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Glucolipotoxicity Alters Insulin Secretion via Epigenetic Changes in Human Islets by Hall, Elin, Jönsson, Josefine, Ofori, Jones K, Volkov, Petr, Perfilyev, Alexander, Dekker Nitert, Marloes, Eliasson, Lena, Ling, Charlotte, Bacos, Karl

“…Type 2 diabetes (T2D) is characterized by insufficient insulin secretion and elevated glucose levels, often in combination with high levels of circulating…”
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Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes by Rönn, Tina, Ofori, Jones K., Perfilyev, Alexander, Hamilton, Alexander, Pircs, Karolina, Eichelmann, Fabian, Garcia-Calzon, Sonia, Karagiannopoulos, Alexandros, Stenlund, Hans, Wendt, Anna, Volkov, Petr, Schulze, Matthias B., Mulder, Hindrik, Eliasson, Lena, Ruhrmann, Sabrina, Bacos, Karl, Ling, Charlotte

“…Epigenetic dysregulation may influence disease progression. Here we explore whether epigenetic alterations in human pancreatic islets impact insulin secretion…”
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Elevated miR-130a/miR130b/miR-152 expression reduces intracellular ATP levels in the pancreatic beta cell by Ofori, Jones K., Salunkhe, Vishal A., Bagge, Annika, Vishnu, Neelanjan, Nagao, Mototsugu, Mulder, Hindrik, Wollheim, Claes B., Eliasson, Lena, Esguerra, Jonathan L. S.

“…MicroRNAs have emerged as important players of gene regulation with significant impact in diverse disease processes. In type-2 diabetes, in which impaired…”
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Partners for life by Eliasson, Lena, Wendt, Anna

“…The hormones insulin and glucagon both play important roles in the development of diabetes…”
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Secretory granule exocytosis and its amplification by cAMP in pancreatic β-cells by Nagao, Mototsugu, Lagerstedt, Jens O., Eliasson, Lena

“…The sequence of events for secreting insulin in response to glucose in pancreatic β-cells is termed “ stimulus-secretion coupling ”. The core of…”
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A critical role of the mechanosensor PIEZO1 in glucose-induced insulin secretion in pancreatic β-cells by Ye, Yingying, Barghouth, Mohammad, Dou, Haiqiang, Luan, Cheng, Wang, Yongzhi, Karagiannopoulos, Alexandros, Jiang, Xiaoping, Krus, Ulrika, Fex, Malin, Zhang, Quan, Eliasson, Lena, Rorsman, Patrik, Zhang, Enming, Renström, Erik

“…Glucose-induced insulin secretion depends on β-cell electrical activity. Inhibition of ATP-regulated potassium (K ATP ) channels is a key event in this…”
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