Comparison of Two Swiss-Designed Hyaluronic Acid Gels: Six-Month Clinical Follow-Up

The aim of this paper is to compare 2 hyaluronic acid gel fillers from the same Swiss manufacturer and with the same indications: filling of line wrinkles and folds. The products differ by their cross-linking process. With very simple easy-to-reproduce tests, cohesivity and resistance to traction fo...

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Bibliographic Details
Published in:	Journal of drugs in dermatology Vol. 16; no. 2; p. 154
Main Authors:	Micheels, Patrick, Sarazin, Didier, Besse, Stéphanie, Eliasd, Badwi
Format:	Journal Article
Language:	English
Published:	United States 01-02-2017
Subjects:	Aged Cosmetic Techniques Drug Compounding Follow-Up Studies Gels Humans Hyaluronic Acid - chemistry Hyaluronic Acid - therapeutic use Middle Aged Skin Aging Surface Properties Switzerland
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Summary:	The aim of this paper is to compare 2 hyaluronic acid gel fillers from the same Swiss manufacturer and with the same indications: filling of line wrinkles and folds. The products differ by their cross-linking process. With very simple easy-to-reproduce tests, cohesivity and resistance to traction forces were examined. Also, both gels were injected under ultrasound control in the mid reticular dermis of three subjects. The papules were controlled under ultrasound and biopsies at D0 and D15. Results showed significant differences between the 2 gels in all the tests. The new gel, manufactured with a lower-crosslinking density, seems to benefit from better integration in the tissue of the mid reticular dermis and to have a more cohesive nature than its comparator from a previous crosslinking technology. Under clinical observation, the range of new products present excellent tissue integration properties. J Drugs Dermatol. 2017;16(2):154-161..
ISSN:	1545-9616