Search Results - "Elias, Mikael H"

Evidence for Complex Interplay between Quorum Sensing and Antibiotic Resistance in Pseudomonas aeruginosa by Sikdar, Rakesh, Elias, Mikael H

“…Quorum sensing (QS) is a cell-density-dependent, intercellular communication system mediated by small diffusible signaling molecules. QS regulates a range of…”
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Conformational rearrangements enable iterative backbone N-methylation in RiPP biosynthesis by Miller, Fredarla S., Crone, Kathryn K., Jensen, Matthew R., Shaw, Sudipta, Harcombe, William R., Elias, Mikael H., Freeman, Michael F.

“…Peptide backbone α- N -methylations change the physicochemical properties of amide bonds to provide structural constraints and other favorable characteristics…”
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Field testing of an enzymatic quorum quencher coating additive to reduce biocorrosion of steel by Huang, Siqian, Bergonzi, Celine, Smith, Sherry, Hicks, Randall E., Elias, Mikael H.

“…ABSTRACT Microbial colonization can be detrimental to the integrity of metal surfaces and lead to microbiologically influenced corrosion. Biocorrosion is a…”
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Changes in Active Site Loop Conformation Relate to the Transition toward a Novel Enzymatic Activity by Jacquet, Pauline, Billot, Raphaël, Shimon, Amir, Hoekstra, Nathan, Bergonzi, Céline, Jenks, Anthony, Chabrière, Eric, Daudé, David, Elias, Mikael H.

“…Enzymatic promiscuity, the ability of enzymes to catalyze multiple, distinct chemical reactions, has been well documented and is hypothesized to be a major…”
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Catalytic Redundancies and Conformational Plasticity Drives Selectivity and Promiscuity in Quorum Quenching Lactonases by Corbella, Marina, Bravo, Joe, Demkiv, Andrey O., Calixto, Ana Rita, Sompiyachoke, Kitty, Bergonzi, Celine, Brownless, Alfie-Louise R., Elias, Mikael H., Kamerlin, Shina Caroline Lynn

“…Several enzymes from the metallo-β-lactamase-like family of lactonases (MLLs) degrade N-acyl L-homoserine lactones (AHLs). They play a role in a microbial…”
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Engineering quorum quenching acylases with improved kinetic and biochemical properties by Sompiyachoke, Kitty, Elias, Mikael H.

“…Many Gram‐negative bacteria use N‐acyl‐L‐homoserine lactone (AHL) signals to coordinate phenotypes such as biofilm formation and virulence factor production…”
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Dinickel enzyme evolved to metabolize the pharmaceutical metformin and its implications for wastewater and human microbiomes by Tassoulas, Lambros J, Rankin, Joel A, Elias, Mikael H, Wackett, Lawrence P

“…Metformin is the first-line treatment for type II diabetes patients and a pervasive pollutant with more than 180 million kg ingested globally and entering…”
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The ineligibility barrier for international researchers in US academia by Elias, Mikael H, Sompiyachoke, Kitty, Fernández, Facundo M, Kamerlin, Shina Caroline Lynn

“…Many grants from US funding agencies are restricted to US citizens or permanent residents which negatively impacts the career options for foreign scientists…”
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Applying molecular and phenotypic screening assays to identify efficient quorum quenching lactonases by Billot, Raphaël, Plener, Laure, Grizard, Damien, Elias, Mikael H., Chabrière, Éric, Daudé, David

“…Quorum sensing (QS) is a molecular communication system used by microorganisms to adopt behaviors in a cell density-dependent manner. Lactonase enzymes, able…”
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Discovery of an ultraspecific triuret hydrolase (TrtA) establishes the triuret biodegradation pathway by Tassoulas, Lambros J., Elias, Mikael H., Wackett, Lawrence P.

“…Triuret (carbonyldiurea) is an impurity found in industrial urea fertilizer (<0.1% w/w) that is applied, worldwide, around 300 million pounds each year on…”
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Dan Salah Tawfik (1955-2021)—A giant of protein evolution by Elias, Mikael H, Fraser, James S, Kamerlin, Shina Caroline Lynn, Patrick, Wayne M, Jackson, Colin J

“…Graphical Abstract…”
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Discovery of an ultra-specific triuret hydrolase (TrtA) establishes the triuret biodegradation pathway by Tassoulas, Lambros J, Elias, Mikael H, Wackett, Lawrence P

“…Triuret (carbonyldiurea) is an impurity found in industrial urea fertilizer (<0.1% w/w) that is applied, worldwide, around 300 million pounds each year on…”
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