Search Results - "Elia, Loredana"

Dasatinib–Blinatumomab for Ph-Positive Acute Lymphoblastic Leukemia in Adults by Foà, Robin, Bassan, Renato, Vitale, Antonella, Elia, Loredana, Piciocchi, Alfonso, Puzzolo, Maria-Cristina, Canichella, Martina, Viero, Piera, Ferrara, Felicetto, Lunghi, Monia, Fabbiano, Francesco, Bonifacio, Massimiliano, Fracchiolla, Nicola, Di Bartolomeo, Paolo, Mancino, Alessandra, De Propris, Maria-Stefania, Vignetti, Marco, Guarini, Anna, Rambaldi, Alessandro, Chiaretti, Sabina

“…In patients who have acute lymphoblastic leukemia with tumor cells that bear the Philadelphia chromosome, traditional therapy is not very effective. The use of…”
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Minimal Residual Disease in Acute Lymphoblastic Leukemia: Technical and Clinical Advances by Della Starza, Irene, Chiaretti, Sabina, De Propris, Maria S, Elia, Loredana, Cavalli, Marzia, De Novi, Lucia A, Soscia, Roberta, Messina, Monica, Vitale, Antonella, Guarini, Anna, Foà, Robin

“…Acute lymphoblastic leukemia (ALL) is the first neoplasm where the assessment of early response to therapy by minimal residual disease (MRD) monitoring has…”
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Prognostic implications of additional genomic lesions in adult Philadelphia chromosome-positive acute lymphoblastic leukemia by Fedullo, Anna Lucia, Messina, Monica, Elia, Loredana, Piciocchi, Alfonso, Gianfelici, Valentina, Lauretti, Alessia, Soddu, Stefano, Puzzolo, Maria Cristina, Minotti, Clara, Ferrara, Felicetto, Martino, Bruno, Chiusolo, Patrizia, Calafiore, Valeria, Paolini, Stefania, Vignetti, Marco, Vitale, Antonella, Guarini, Anna, Foà, Robin, Chiaretti, Sabina

“…To shed light onto the molecular basis of Philadelphia chromosome-positive acute lymphoblastic leukemia and to investigate the prognostic role of additional…”
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A multicenter total therapy strategy for de novo adult Philadelphia chromosome positive acute lymphoblastic leukemia patients. Final results of the GIMEMA LAL1509 protocol by Chiaretti, Sabina, Ansuinelli, Michela, Vitale, Antonella, Elia, Loredana, Matarazzo, Mabel, Piciocchi, Alfonso, Fazi, Paola, Di Raimondo, Francesco, Santoro, Lidia, Fabbiano, Francesco, Califano, Catello, Martinelli, Giovanni, Ronco, Francesca, Ferrara, Felicetto, Cascavilla, Nicola, Bigazzi, Catia, Tedeschi, Alessandra, Sica, Simona, Di Renzo, Nicola, Melpignano, Angela, Beltrami, Germana, Vignetti, Marco, Foa, Robin

“…The GIMEMA LAL1509 protocol, designed for adult (≥18-60 years) de novo Ph+ acute lymphoblastic leukemia patients, was based on a dasatinib plus steroids…”
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IKZF1 (Ikaros) Deletions in BCR-ABL1–Positive Acute Lymphoblastic Leukemia Are Associated With Short Disease-Free Survival and High Rate of Cumulative Incidence of Relapse: A GIMEMA AL WP Report by MARTINELLI, Giovanni, IACOBUCCI, Ilaria, PAPAYANNIDIS, Cristina, PAOLINI, Stefania, ELIA, Loredana, FAZI, Paola, MELONI, Giovanna, AMADORI, Sergio, SAGLIO, Giuseppe, PANE, Fabrizio, BACCARANI, Michele, FOA, Robin, TIZIAVA STORLAZZI, Clelia, VIGNETTI, Marco, PAOLONI, Francesca, CILLONI, Daniela, SOVERINI, Simona, VITALE, Antonella, CHIARETTI, Sabina, CIMINO, Giuseppe

“…The causes of the aggressive nature of BCR-ABL1-positive adult acute lymphoblastic leukemia (ALL) are unknown. To identify, at the submicroscopic level,…”
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Flow cytometric study of potential target antigens (CD19, CD20, CD22, CD33) for antibody-based immunotherapy in acute lymphoblastic leukemia: analysis of 552 cases by Raponi, Sara, Stefania De Propris, Maria, Intoppa, Stefania, Laura Milani, Maria, Vitale, Antonella, Elia, Loredana, Perbellini, Omar, Pizzolo, Giovanni, Foá, Robin, Guarini, Anna

“…Monoclonal antibody (MoAb)-based therapies have opened innovative treatment avenues that have impacted on the management of patients with both neoplastic and…”
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A sequential approach with imatinib, chemotherapy and transplant for adult Ph+ acute lymphoblastic leukemia: final results of the GIMEMA LAL 0904 study by Chiaretti, Sabina, Vitale, Antonella, Vignetti, Marco, Piciocchi, Alfonso, Fazi, Paola, Elia, Loredana, Falini, Brunangelo, Ronco, Francesca, Ferrara, Felicetto, De Fabritiis, Paolo, Luppi, Mario, La Nasa, Giorgio, Tedeschi, Alessandra, Califano, Catello, Fanin, Renato, Dore, Fausto, Mandelli, Franco, Meloni, Giovanna, Foà, Robin

“…In the GIMEMA LAL 0904 protocol, adult Philadelphia positive acute lymphoblastic leukemia patients were treated with chemotherapy for induction and…”
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Clinico-biological features of 5202 patients with acute lymphoblastic leukemia enrolled in the Italian AIEOP and GIMEMA protocols and stratified in age cohorts by Chiaretti, Sabina, Vitale, Antonella, Cazzaniga, Gianni, Orlando, Sonia Maria, Silvestri, Daniela, Fazi, Paola, Valsecchi, Maria Grazia, Elia, Loredana, Testi, Anna Maria, Mancini, Francesca, Conter, Valentino, te Kronnie, Geertruy, Ferrara, Felicetto, Di Raimondo, Francesco, Tedeschi, Alessandra, Fioritoni, Giuseppe, Fabbiano, Francesco, Meloni, Giovanna, Specchia, Giorgina, Pizzolo, Giovanni, Mandelli, Franco, Guarini, Anna, Basso, Giuseppe, Biondi, Andrea, Foà, Robin

“…The outcome of children and adults with acute lymphoblastic leukemia is markedly different. Since there is limited information on the distribution of…”
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CD146 MOLECULE EXPRESSION IN B CELLS ACUTE LYMPHOBLASTIC LEUKEMIA (B-ALLs): A FLOW- CYTOMETRIC MARKER FOR AN ACCURATE DIAGNOSTIC WORK-UP by Laganà, Alessandro, Totaro, Matteo, Bisegna, Maria Laura, Elia, Loredana, Intoppa, Stefania, Beldinanzi, Marco, Matarazzo, Mabel, Di Trani, Mariangela, Costa, Alessandro, Maglione, Raffaele, Mandelli, Biancamaria, Chiaretti, Sabina, Martelli, Maurizio, De Propris, Maria Stefania

“…Background: B-lineage acute lymphoblastic leukemias (B-ALL) harboring the t(9;22)(q34;q11)/BCR::ABL1rearrangement, represent a category with previously dismal…”
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NG2 Molecule Expression in Acute Lymphoblastic Leukemia B Cells: A Flow-Cytometric Marker for the Rapid Identification of KMT2A Gene Rearrangements by Bisegna, Maria Laura, Peragine, Nadia, Elia, Loredana, Matarazzo, Mabel, Milani, Maria Laura, Intoppa, Stefania, Di Trani, Mariangela, Malfona, Francesco, Martelli, Maurizio, De Propris, Maria Stefania

“…B-lineage acute lymphoblastic leukemias (B-ALL) harboring rearrangements of the histone lysine [K]-Methyltransferase 2A ( ) gene on chromosome 11q23 ( )…”
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RNA sequencing unravels the genetics of refractory/relapsed T-cell acute lymphoblastic leukemia. Prognostic and therapeutic implications by Gianfelici, Valentina, Chiaretti, Sabina, Demeyer, Sofie, Di Giacomo, Filomena, Messina, Monica, La Starza, Roberta, Peragine, Nadia, Paoloni, Francesca, Geerdens, Ellen, Pierini, Valentina, Elia, Loredana, Mancini, Marco, De Propris, Maria Stefania, Apicella, Valerio, Gaidano, Gianluca, Testi, Anna Maria, Vitale, Antonella, Vignetti, Marco, Mecucci, Cristina, Guarini, Anna, Cools, Jan, Foà, Robin

“…Despite therapeutic improvements, a sizable number of patients with T-cell acute lymphoblastic leukemia still have a poor outcome. To unravel the genomic…”
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PB1711: DROPLET DIGITAL PCR DETECTION OF THE T315I BCR::ABL1 KD MUTATION IN ADULT PH‐POSITIVE ACUTE LYMPHOBLASTIC LEUKEMIA by Cardinali, Deborah, Beldinanzi, Marco, Ansuinelli, Michela, Elia, Loredana, Starza, Irene Della, Bellomarino, Vittorio, Matarazzo, Mabel, Trani, Mariangela DI, Cola, Mattia, Guarini, Anna Rita, Foà, Robin, Chiaretti, Sabina

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Philadelphia-positive acute lymphoblastic leukemia patients already harbor BCR-ABL kinase domain mutations at low levels at the time of diagnosis by SOVERINI, Simona, VITALE, Antonella, PAOLINI, Stefania, MELONI, Giovanna, DI MAIO, Valeria, PAPAYANNIDIS, Cristina, AMABILE, Marilina, GUARINI, Anna, BACCARANI, Michele, MARTINELLI, Giovanni, FOA, Robin, POERIO, Angela, GNANI, Alessandra, COLAROSSI, Sabrina, IACOBUCCI, Ilaria, CIMINO, Giuseppe, ELIA, Loredana, LONETTI, Annalisa, VIGNETTI, Marco

“…In patients with Philadelphia-positive acute lymphoblastic leukemia, resistance to treatment with tyrosine kinase inhibitors is frequent and most often…”
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DDX3X-MLLT10 fusion in adults with NOTCH1 positive T-cell acute lymphoblastic leukemia by Brandimarte, Lucia, La Starza, Roberta, Gianfelici, Valentina, Barba, Gianluca, Pierini, Valentina, Di Giacomo, Danika, Cools, Jan, Elia, Loredana, Vitale, Antonella, Luciano, Luigiana, Bardi, Antonella, Chiaretti, Sabina, Matteucci, Caterina, Specchia, Giorgina, Mecucci, Cristina

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Multicenter Total Therapy Gimema LAL 1509 Protocol for De Novo Adult Ph+ Acute Lymphoblastic Leukemia (ALL) Patients. Updated Results and Refined Genetic-Based Prognostic Stratification by Chiaretti, Sabina, Vitale, Antonella, Elia, Loredana, Fedullo, Anna Lucia, Albino, Silvana, Piciocchi, Alfonso, Fazi, Paola, Di Raimondo, Francesco, Fornaro, Antonella, Fabbiano, Francesco, D'Arco, Alfonso Maria, Martinelli, Giovanni, Ronco, Francesca, Santoro, Lidia Edwige, Cascavilla, Nicola, Galieni, Piero, Tedeschi, Alessandra, Sica, Simona, Di Renzo, Nicola, Melpignano, Angela, Carella, Angelo Michele, Ferrara, Felicetto, Vignetti, Marco, Foà, Robin

“…Introduction: Management of Ph+ ALL has changed since the introduction of tyrosine kinase inhibitors (TKI). We previously reported the preliminary findings of…”
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Gene expression profiling identifies a subset of adult T-cell acute lymphoblastic leukemia with myeloid-like gene features and over-expression of miR-223 by CHIARETTI, Sabina, MESSINA, Monica, BOZZONI, Irene, FOZZA, Claudio, CANDONI, Anna, GUARINI, Anna, FOA, Robin, TAVOLARO, Simona, ZARDO, Giuseppe, ELIA, Loredana, VITALE, Antonella, FATICA, Alessandro, GOREL, Paolo, PICIOCCHI, Alfonso, SCAPPUCCI, Gina

“…Until recently, few molecular aberrations were recognized in acute lymphoblastic leukemia of T-cell origin; novel lesions have recently been identified and a…”
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The PAX5 gene is frequently rearranged in BCR-ABL1-positive acute lymphoblastic leukemia but is not associated with outcome. A report on behalf of the GIMEMA Acute Leukemia Working Party by IACOBUCCI, Ilaria, LONETTI, Annalisa, PAOLINI, Stefania, ELIA, Loredana, MESSINA, Monica, VITALE, Antonella, MELONI, Giovanna, SOVERINI, Simona, PANE, Fabrizio, BACCARANI, Michele, FOA, Robin, MARTINELLI, Giovanni, PAOLONI, Francesca, PAPAYANNIDIS, Cristina, FERRARI, Anna, TIZIANA STORLAZZI, Clelia, VIGNETTI, Marco, CILLONI, Daniela, MESSA, Francesca, GUADAGNUOLO, Viviana

“…Recently, in genome-wide analyses of DNA copy number abnormalities using single nucleotide polymorphism microarrays, genetic alterations targeting PAX5 were…”
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Combined interphase fluorescence in situ hybridization elucidates the genetic heterogeneity of T-cell acute lymphoblastic leukemia in adults by GORELLO, Paolo, LA STARZA, Roberta, MESSINA, Monica, GRAMMATICO, Sara, MANCINI, Marco, MATTEUCCI, Caterina, BARDI, Antonella, GUARINI, Anna, MARTELLI, Massimo Fabrizio, FOA, Robin, MECUCCI, Cristina, VARASANO, Emanuela, CHIARETTI, Sabina, ELIA, Loredana, PIERINI, Valentina, BARBA, Gianluca, BRANDIMARTE, Lucia, CRESCENZI, Barbara, VITALE, Antonella

“…Molecular lesions in T-cell acute lymphoblastic leukemias affect regulators of cell cycle, proliferation, differentiation, survival and apoptosis in multi-step…”
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An accurate and rapid flow cytometric diagnosis of BCR-ABL positive acute lymphoblastic leukemia by RAPONI, Sara, STEFANIA DE PROPRIS, Maria, WAI, Hobert, INTOPPA, Stefania, ELIA, Loredana, DIVERIO, Daniela, VITALE, Antonella, FOA, Robin, GUARINI, Anna

“…Tyrosine kinase inhibitors have profoundly modified the treatment and prognosis of chronic myeloid leukemia and Ph(+) acute lymphoblastic leukemia. A rapid and…”
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The therapeutic response and clinical outcome of adults with ALL1(MLL)/AF4 fusion positive acute lymphoblastic leukemia according to the GIMEMA experience by CIMINO, Giuseppe, CENFRA, Natalia, ELIA, Loredana, SICA, Simona, LUPPI, Mario, MELONI, Giovanna, VIGNETTI, Marco, PAOLONI, Francesca, FOA, Robin, MANDELLI, Franco

“…The clinical outcome of 21 adults with ALL1(MLL)/AF4 positive acute lymphoblastic leukemia enrolled in the GIMEMA LAL 2000 trial and of 25 patients entered…”
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