Search Results - "Elia, Lisa P."

Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway by Elia, Lisa P, Mason, Amanda R, Alijagic, Amela, Finkbeiner, Steven

“…Deficient progranulin levels cause dose-dependent neurological syndromes: haploinsufficiency leads to frontotemporal lobar degeneration (FTLD) and…”
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p120 Catenin Regulates Dendritic Spine and Synapse Development through Rho-Family GTPases and Cadherins by Elia, Lisa P., Yamamoto, Miya, Zang, Keling, Reichardt, Louis F.

“…Both the cadherin-catenin complex and Rho-family GTPases have been shown to regulate dendrite development. We show here a role for p120 catenin (p120ctn) in…”
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Approaches to develop therapeutics to treat frontotemporal dementia by Elia, Lisa P., Reisine, Terry, Alijagic, Amela, Finkbeiner, Steven

“…Frontotemporal degeneration (FTD) is a complex disease presenting as a spectrum of clinical disorders with progressive degeneration of frontal and temporal…”
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Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models by Minami, S Sakura, Min, Sang-Won, Krabbe, Grietje, Wang, Chao, Zhou, Yungui, Asgarov, Rustam, Li, Yaqiao, Martens, Lauren H, Elia, Lisa P, Ward, Michael E, Mucke, Lennart, Farese, Robert V, Gan, Li

“…Progranulin overexpression in Alzheimer's disease model mice protects against neuronal loss and enhances cognitive deficits. Haploinsufficiency of the…”
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The Receptor-interacting Serine/Threonine Protein Kinase 1 (RIPK1) Regulates Progranulin Levels by Mason, Amanda R., Elia, Lisa P., Finkbeiner, Steven

“…Progranulin (PGRN), a secreted growth factor, is a key regulator of inflammation and is genetically linked to two common and devastating neurodegenerative…”
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Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and β-catenin by Lee, Seung-Hye, Peng, I.-Feng, Ng, Yu Gie, Yanagisawa, Masahiro, Bamji, Shernaz X, Elia, Lisa P, Balsamo, Janne, Lilien, Jack, Anastasiadis, Panos Z, Ullian, Erik M, Reichardt, Louis F

“…Localization of presynaptic components to synaptic sites is critical for hippocampal synapse formation. Cell adhesion-regulated signaling is important for…”
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Progranulin protects against amyloid [beta] deposition and toxicity in Alzheimer's disease mouse models by Minami, S Sakura, Min, Sang-won, Krabbe, Grietje, Wang, Chao, Zhou, Yungui, Asgarov, Rustam, Li, Yaqiao, Martens, Lauren H, Elia, Lisa P, Ward, Michael E, Mucke, Lennart, Farese, Robert V, Gan, Li

“…Haploinsufficiency of the progranulin (PGRN) gene (GRN) causes familial frontotemporal lobar degeneration (FTLD) and modulates an innate immune response in…”
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Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and [beta]-catenin by Lee, Seung-Hye, Peng, I-Feng, Ng, Yu Gie, Yanagisawa, Masahiro, Bamji, Shernaz X, Elia, Lisa P, Balsamo, Janne, Lilien, Jack, Anastasiadis, Panos Z, Ullian, Erik M, Reichardt, Louis F

“…Localization of presynaptic components to synaptic sites is critical for hippocampal synapse formation. Cell adhesion - regulated signaling is important for…”
Get full text