Search Results - "Elia, Andrew"

Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response by Elia, Andrew E.H., Boardman, Alexander P., Wang, David C., Huttlin, Edward L., Everley, Robert A., Dephoure, Noah, Zhou, Chunshui, Koren, Itay, Gygi, Steven P., Elledge, Stephen J.

“…Execution of the DNA damage response (DDR) relies upon a dynamic array of protein modifications. Using quantitative proteomics, we have globally profiled…”
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Global Identification of Modular Cullin-RING Ligase Substrates by Emanuele, Michael J., Elia, Andrew E.H., Xu, Qikai, Thoma, Claudio R., Izhar, Lior, Leng, Yumei, Guo, Ailan, Chen, Yi-Ning, Rush, John, Hsu, Paul Wei-Che, Yen, Hsueh-Chi Sherry, Elledge, Stephen J.

“…Cullin-RING ligases (CRLs) represent the largest E3 ubiquitin ligase family in eukaryotes, and the identification of their substrates is critical to…”
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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells by Nauli, Surya M., Alenghat, Francis J., Luo, Ying, Williams, Eric, Vassilev, Peter, Li, Xiaogang, Elia, Andrew E H., Lu, Weining, Brown, Edward M., Quinn, Stephen J., Ingber, Donald E., Zhou, Jing

“…Several proteins implicated in the pathogenesis of polycystic kidney disease (PKD) localize to cilia. Furthermore, cilia are malformed in mice with PKD with…”
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RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks by Elia, Andrew E.H., Wang, David C., Willis, Nicholas A., Boardman, Alexander P., Hajdu, Ildiko, Adeyemi, Richard O., Lowry, Elizabeth, Gygi, Steven P., Scully, Ralph, Elledge, Stephen J.

“…We have used quantitative proteomics to profile ubiquitination in the DNA damage response (DDR). We demonstrate that RPA, which functions as a protein scaffold…”
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RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of stalled replication forks by Moore, Chandler E, Yalcindag, Selin E, Czeladko, Hanna, Ravindranathan, Ramya, Wijesekara Hanthi, Yodhara, Levy, Juliana C, Sannino, Vincenzo, Schindler, Detlev, Ciccia, Alberto, Costanzo, Vincenzo, Elia, Andrew E H

“…Replication fork reversal is an important mechanism to protect the stability of stalled forks and thereby preserve genomic integrity. While multiple enzymes…”
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The CD225 Domain of IFITM3 Is Required for both IFITM Protein Association and Inhibition of Influenza A Virus and Dengue Virus Replication by John, Sinu P, Chin, Christopher R, Perreira, Jill M, Feeley, Eric M, Aker, Aaron M, Savidis, George, Smith, Sarah E, Elia, Andrew E H, Everitt, Aaron R, Vora, Mehul, Pertel, Thomas, Elledge, Stephen J, Kellam, Paul, Brass, Abraham L

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate by Emanuele, Michael J, Ciccia, Alberto, Elia, Andrew E.H, Elledge, Stephen J

“…The anaphase-promoting complex/cyclosome (APC/C) is a cell cycle-regulated E3 ubiquitin ligase that controls the degradation of substrate proteins at mitotic…”
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Chromatin proteins captured by ChIP–mass spectrometry are linked to dosage compensation in Drosophila by Wang, Charlotte I, Alekseyenko, Artyom A, LeRoy, Gary, Elia, Andrew EH, Gorchakov, Andrey A, Britton, Laura-Mae P, Elledge, Stephen J, Kharchenko, Peter V, Garcia, Benjamin A, Kuroda, Mitzi I

“…The MSL complex acts on chromatin to and is required for X-chromosome dosage compensation. Chromatin-interacting protein MS (ChIP-MS) is now used to identify…”
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Proteomic Screen Finds pSer/pThr-Binding Domain Localizing Plk1 to Mitotic Substrates by Andrew E. H. Elia, Cantley, Lewis C., Yaffe, Michael B.

“…We have developed a proteomic approach for identifying phosphopeptide binding domains that modulate kinase-dependent signaling pathways. An immobilized library…”
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E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells by Duan, Haohui, Mansour, Sarah, Reed, Rachel, Gillis, Margaret K, Parent, Benjamin, Liu, Ben, Sztupinszki, Zsofia, Birkbak, Nicolai, Szallasi, Zoltan, Elia, Andrew E H, Garber, Judy E, Pathania, Shailja

“…BRCA1/2 help maintain genomic integrity by stabilizing stalled forks. Here, we identify the E3 ligase RFWD3 as an essential modulator of stalled fork stability…”
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A role for PVRL4-driven cell-cell interactions in tumorigenesis by Pavlova, Natalya N, Pallasch, Christian, Elia, Andrew E H, Braun, Christian J, Westbrook, Thomas F, Hemann, Michael, Elledge, Stephen J

“…During all stages of tumor progression, cancer cells are subjected to inappropriate extracellular matrix environments and must undergo adaptive changes in…”
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Hypoxia-inducible factor 1 alpha limits dendritic cell stimulation of CD8 T cell immunity by Tran, Charles W, Gold, Matthew J, Garcia-Batres, Carlos, Tai, Kelly, Elford, Alisha R, Himmel, Megan E, Elia, Andrew J, Ohashi, Pamela S

“…Dendritic cells are sentinels of the immune system and represent a key cell in the activation of the adaptive immune response. Hypoxia-inducible factor 1 alpha…”
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The Protexin complex counters resection on stalled forks to promote homologous recombination and crosslink repair by Adeyemi, Richard O., Willis, Nicholas A., Elia, Andrew E.H., Clairmont, Connor, Li, Shibo, Wu, Xiaohua, D’Andrea, Alan D., Scully, Ralph, Elledge, Stephen J.

“…Protection of stalled replication forks is critical to genomic stability. Using genetic and proteomic analyses, we discovered the Protexin complex containing…”
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Glioblastoma in elderly patients: solid conclusions built on shifting sand? by Wick, Antje, Kessler, Tobias, Elia, Andrew E H, Winkler, Frank, Batchelor, Tracy T, Platten, Michael, Wick, Wolfgang

“…Management of glioblastoma in the elderly population is challenging. In the near future, more than half of patients with this tumor will be over the age of 65…”
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D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function by Sasaki, Masato, Knobbe, Christiane B, Itsumi, Momoe, Elia, Andrew J, Harris, Isaac S, Chio, Iok In Christine, Cairns, Rob A, McCracken, Susan, Wakeham, Andrew, Haight, Jillian, Ten, Annick You, Snow, Bryan, Ueda, Takeshi, Inoue, Satoshi, Yamamoto, Kazuo, Ko, Myunggon, Rao, Anjana, Yen, Katharine E, Su, Shinsan M, Mak, Tak Wah

“…Isocitrate dehydrogenase-1 (IDH1) R132 mutations occur in glioma, but their physiological significance is unknown. Here we describe the generation and…”
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Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2 by Inoue, Satoshi, Li, Wanda Y., Tseng, Alan, Beerman, Isabel, Elia, Andrew J., Bendall, Sean C., Lemonnier, François, Kron, Ken J., Cescon, David W., Hao, Zhenyue, Lind, Evan F., Takayama, Naoya, Planello, Aline C., Shen, Shu Yi, Shih, Alan H., Larsen, Dana M., Li, Qinxi, Snow, Bryan E., Wakeham, Andrew, Haight, Jillian, Gorrini, Chiara, Bassi, Christian, Thu, Kelsie L., Murakami, Kiichi, Elford, Alisha R., Ueda, Takeshi, Straley, Kimberly, Yen, Katharine E., Melino, Gerry, Cimmino, Luisa, Aifantis, Iannis, Levine, Ross L., De Carvalho, Daniel D., Lupien, Mathieu, Rossi, Derrick J., Nolan, Garry P., Cairns, Rob A., Mak, Tak W.

“…Mutations in the isocitrate dehydrogenase-1 gene (IDH1) are common drivers of acute myeloid leukemia (AML) but their mechanism is not fully understood. It is…”
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Glutathione and Thioredoxin Antioxidant Pathways Synergize to Drive Cancer Initiation and Progression by Harris, Isaac S., Treloar, Aislinn E., Inoue, Satoshi, Sasaki, Masato, Gorrini, Chiara, Lee, Kim Chung, Yung, Ka Yi, Brenner, Dirk, Knobbe-Thomsen, Christiane B., Cox, Maureen A., Elia, Andrew, Berger, Thorsten, Cescon, David W., Adeoye, Adewunmi, Brüstle, Anne, Molyneux, Sam D., Mason, Jacqueline M., Li, Wanda Y., Yamamoto, Kazuo, Wakeham, Andrew, Berman, Hal K., Khokha, Rama, Done, Susan J., Kavanagh, Terrance J., Lam, Ching-Wan, Mak, Tak W.

“…Controversy over the role of antioxidants in cancer has persisted for decades. Here, we demonstrate that synthesis of the antioxidant glutathione (GSH), driven…”
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Profiling DNA damage-induced phosphorylation in budding yeast reveals diverse signaling networks by Zhou, Chunshui, Elia, Andrew E. H., Naylor, Maria L., Dephoure, Noah, Ballif, Bryan A., Goel, Gautam, Xu, Qikai, Ng, Aylwin, Chou, Danny M., Xavier, Ramnik J., Gygi, Steven P., Elledge, Stephen J.

“…The DNA damage response (DDR) is regulated by a protein kinase signaling cascade that orchestrates DNA repair and other processes. Identifying the substrate…”
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Therapeutic inhibition of USP9x-mediated Notch signaling in triple-negative breast cancer by Jaiswal, Arushi, Murakami, Kiichi, Elia, Andrew, Shibahara, Yukiko, Done, Susan J., Wood, Stephen A., Donato, Nicholas J., Ohashi, Pamela S., Reedijk, Michael

“…Triple-negative breast cancer (TNBC) is a breast cancer subtype that lacks targeted treatment options. The activation of the Notch developmental signaling…”
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BRCA1 interacts with Nrf2 to regulate antioxidant signaling and cell survival by Gorrini, Chiara, Baniasadi, Pegah S, Harris, Isaac S, Silvester, Jennifer, Inoue, Satoshi, Snow, Bryan, Joshi, Purna A, Wakeham, Andrew, Molyneux, Sam D, Martin, Bernard, Bouwman, Peter, Cescon, David W, Elia, Andrew J, Winterton-Perks, Zoe, Cruickshank, Jennifer, Brenner, Dirk, Tseng, Alan, Musgrave, Melinda, Berman, Hal K, Khokha, Rama, Jonkers, Jos, Mak, Tak W, Gauthier, Mona L

“…Oxidative stress plays an important role in cancer development and treatment. Recent data implicate the tumor suppressor BRCA1 in regulating oxidative stress,…”
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