Outcomes of combined use of topical and intravenous tranexamic acid on surgical field quality during functional endoscopic sinus surgery: Randomized controlled trial

Outcomes of combined use of topical and intravenous tranexamic acid on surgical field quality during functional endoscopic sinus surgery: Randomized controlled trial

Background Intraoperative bleeding during functional endoscopic sinus surgery (FESS) poses a challenge to both surgeon and anesthetist. The primary aim of this study was to evaluate the effectiveness of local, intravenous and combined use of tranexamic acid (TA) in improving the surgical field quali...

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Published in:Head & neck Vol. 43; no. 5; pp. 1389 - 1397
Main Authors: El‐Ozairy, Hala Salah El‐Din, Mady, Ossama Mustafa, Tawfik, Gehad Mohamed, Elhennawy, Ahmed Mohamed, Teaima, Ahmed Abdelmoneim, Ebied, Amr, Huy, Nguyen Tien
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01-05-2021
Wiley Subscription Services, Inc
Subjects:
Anesthesia
Antifibrinolytic agents
Blood pressure
Endoscopy
Fentanyl
FESS
Head and neck
Heart rate
Hematocrit
Hemoglobin
intravenous
Intravenous administration
mean arterial pressure
Placebos
Prothrombin
Statistical analysis
Surgery
Thromboplastin
topical
tranexamic acid
topical
intravenous
mean arterial pressure
tranexamic acid
FESS
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Summary:Background Intraoperative bleeding during functional endoscopic sinus surgery (FESS) poses a challenge to both surgeon and anesthetist. The primary aim of this study was to evaluate the effectiveness of local, intravenous and combined use of tranexamic acid (TA) in improving the surgical field quality during FESS. Methods We conducted a randomized controlled double‐blinded prospective trial on 120 patients scheduled for elective FESS. After induction of general anesthesia, patients were randomly and evenly assigned to one of four groups; IV TA, local TA, both IV and local TA, and placebo. Surgical field was assessed using five‐point Boezaart scale. Total fentanyl and esmolol consumption, operative time, recovery time, and postoperative complications were recorded. Results Surgical field quality score was the best in IV and local TA group compared to others (p < 0.001). Mean operative time was found significantly shorter in IV and local TA group than placebo one. Total fentanyl consumption was significantly lower in IV and local TA group comparing to others (p = 0.025). Mean recovery time was significantly shorter for IV and local TA group compared to others. Total fentanyl consumption was significantly lower in IV and local TA group comparing to others. No significant differences were found of mean arterial pressure and heart rate decline in four groups. None of the patients in four groups required esmolol administration. No statistically significant differences were found in change of hemoglobin, hematocrit, prothrombin time, and partial thromboplastin time over time in all groups. Conclusion The combined use of topical and intravenous TA provided the best surgical field in FESS, less fentanyl consumption, and less recovery time without causing significant side effects.
Bibliography:Hala Salah El‐Din El‐Ozairy, Ossama Mustafa Mady, and Gehad Mohamed Tawfik contributed equally to this study.
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ISSN:1043-3074
1097-0347
DOI:10.1002/hed.26610