Search Results - "Elghazi, L"

Regulation of β-cell mass and function by the Akt/protein kinase B signalling pathway by Elghazi, L, Rachdi, L, Weiss, A.J, Cras-Méneur, C, Bernal-Mizrachi, E

“…The insulin receptor substrate-2/phosphoinositide 3-kinase (PI3K) pathway plays a critical role in the regulation of β-cell mass and function, demonstrated…”
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Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21 Cip by Blandino-Rosano, M., Alejandro, E. U., Sathyamurthy, A., Scheys, J. O., Gregg, B., Chen, A. Y., Rachdi, L., Weiss, A., Barker, D. J., Gould, A. P., Elghazi, L., Bernal-Mizrachi, E.

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Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21Cip by Blandino-Rosano, M., Alejandro, E. U., Sathyamurthy, A., Scheys, J. O., Gregg, B., Chen, A. Y., Rachdi, L., Weiss, A., Barker, D. J., Gould, A. P., Elghazi, L., Bernal-Mizrachi, E.

“…Aims/hypothesis The ability of pancreatic beta cells to proliferate is critical both for normal tissue maintenance and in conditions where there is an…”
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Ghrelin Cells Replace Insulin-Producing β Cells in Two Mouse Models of Pancreas Development by Prado, Catherine L., Pugh-Bernard, Aimee E., Elghazi, Lynda, Sosa-Pineda, Beatriz, Sussel, Lori, Malins, Donald C.

“…The pancreatic islet is necessary for maintaining glucose homeostasis. Within the pancreatic islet, the homeodomain protein Nkx2.2 is essential for the…”
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Akt Induces β-Cell Proliferation by Regulating Cyclin D1, Cyclin D2, and p21 Levels and Cyclin-Dependent Kinase-4 Activity by Fatrai, Szabolcs, Elghazi, Lynda, Balcazar, Norman, Cras-Méneur, Corentin, Krits, Irina, Kiyokawa, Hiroaki, Bernal-Mizrachi, Ernesto

“…Akt Induces β-Cell Proliferation by Regulating Cyclin D1, Cyclin D2, and p21 Levels and Cyclin-Dependent Kinase-4 Activity Szabolcs Fatrai 1 , Lynda Elghazi 1…”
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MafB : An activator of the glucagon gene expressed in developing islet α- and β-cells by ARTNER, Isabella, LE LAY, John, YAN HANG, ELGHAZI, Lynda, SCHISLER, Jonathan C, HENDERSON, Eva, SOSA-PINEDA, Beatriz, STEIN, Roland

“…The large Maf family of basic leucine-zipper-containing transcription factors are known regulators of key developmental and functional processes in various…”
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Emerging role of protein kinase B/Akt signaling in pancreatic β-cell mass and function by Elghazi, Lynda, Balcazar, Norman, Bernal-Mizrachi, Ernesto

“…The serine-threonine kinase Akt also known as protein kinase B is one of the most studied molecules. In addition to the important role in carcinogenesis, Akt…”
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The concerted activities of Pax4 and Nkx2.2 are essential to initiate pancreatic β-cell differentiation by Wang, Junfeng, Elghazi, Lynda, Parker, Susan E, Kizilocak, Hasan, Asano, Masahide, Sussel, Lori, Sosa-Pineda, Beatriz

“…Pancreatic β cells play a central role in maintaining glucose homeostasis because they secrete insulin in response to increased level of blood glucose; failure…”
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Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating death-inducing signaling complex components into ceramide-enriched caveolae by MARTIN, Sophie, PHILLIPS, Darren C, SZEKELY-SZUCS, Kinga, ELGHAZI, Lynda, DESMOTS, Fabienne, HOUGHTON, Janet A

“…Cyclooxygenase-2 (COX-2) is up-regulated in human colon carcinomas, and its inhibition is associated with a reduction in tumorigenesis and a promotion of…”
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Epidermal growth factor increases undifferentiated pancreatic embryonic cells in vitro: A balance between proliferation and differentiation by CRAS-MENEUR, Corentin, ELGHAZI, Lynda, CZERNICHOW, Paul, SCHARFMANN, Raphael

“…During embryonic life, the development of a proper mass of mature pancreatic tissue is thought to require the proliferation of precursor cells, followed by…”
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ghrelin is a novel target of Pax4 in endocrine progenitors of the pancreas and duodenum by Wang, Qian, Elghazi, Lynda, Martin, Sophie, Martins, Isabelle, Srinivasan, R. Satish, Geng, Xin, Sleeman, Mark, Collombat, Patrick, Houghton, Janet, Sosa‐Pineda, Beatriz

“…Pax4‐deficient mice have a severe gastrointestinal endocrine deficiency: they lack most pancreatic cells that produce insulin or somatostatin and various…”
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Emerging role of protein kinase B/Akt signaling in pancreatic β-cell mass and function by Elghazi, Lynda, Balcazar, Norman, Bernal-Mizrachi, Ernesto

“…The serine-threonine kinase Akt also known as protein kinase B is one of the most studied molecules. In addition to the important role in carcinogenesis, Akt…”
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Role for FGFR2IIIb-Mediated Signals in Controlling Pancreatic Endocrine Progenitor Cell Proliferation by Elghazi, Lynda, Cras-Méneur, Corentin, Czernichow, Paul, Scharfmann, Raphael

“…Pancreatic development is a classic example of epithelium-mesenchyme interaction. During embryonic life, signals from the mesenchyme control the proliferation…”
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Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21 super(Cip) by Blandino-Rosano, M, Alejandro, E U, Sathyamurthy, A, Scheys, JO, Gregg, B, Chen, A Y, Rachdi, L, Weiss, A, Barker, D J, Gould, A P, Elghazi, L, Bernal-Mizrachi, E

“…Aims/hypothesis: The ability of pancreatic beta cells to proliferate is critical both for normal tissue maintenance and in conditions where there is an…”
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Enhanced beta cell proliferation in mice overexpressing a constitutively active form of Akt and one allele of p21 ^sup Cip by Blandino-rosano, M, Alejandro, E U, Sathyamurthy, A, Scheys, J O, Gregg, B, Chen, A Y, Rachdi, L, Weiss, A, Barker, D J, Gould, A P, Elghazi, L, Bernal-mizrachi, E

“…The ability of pancreatic beta cells to proliferate is critical both for normal tissue maintenance and in conditions where there is an increased demand for…”
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Cyclooxygenase-2 inhibition sensitizes human colon carcinoma cells to TRAIL-induced apoptosis through clustering of DR5 and concentrating Death-Induced Signaling Complex components into ceramide-enriched caveolae by Martin, S., Phillips, D.C., Szekely-Szucs, K., Elghazi, L., Desmots, F., Houghton, J.A.

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